Individualized, Additively Manufactured Drug-Releasing External Ear Canal Implant for Prevention of Postoperative Restenosis: Development, In Vitro Testing, and Proof of Concept in an Individual Curative Trial

Individualized, Additively Manufactured Drug-Releasing External Ear Canal Implant for Prevention of Postoperative Restenosis: Development, In Vitro Testing, and Proof of Concept in an Individual Curative Trial

Postoperative restenosis in patients with external ear canal (EEC) atresia or stenosis is a common complication following canaloplasty. Our aim in this study was to explore the feasibility of using a three dimensionally (3D)-printed, patient-individualized, drug ((dexamethasone (DEX)), and ciproflox...

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Bibliographic Details
Main Authors: Farnaz Matin-Mann, Ziwen Gao, Jana Schwieger, Martin Ulbricht, Vanessa Domsta, Stefan Senekowitsch, Werner Weitschies, Anne Seidlitz, Katharina Doll, Meike Stiesch, Thomas Lenarz, Verena Scheper
Format: Article
Language:English
Published: MDPI AG 2022-06-01
Series:Pharmaceutics
Subjects:
ear canal stenosis
personalized implant
drug-eluting implant
additive manufacturing
preoperative workflow
external auditory canal
Online Access:https://www.mdpi.com/1999-4923/14/6/1242

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