Basic mechanisms of primary infertility in reproductive age women with hypothalamic dysfunction in puberty
Hypothalamic dysfunction is the most common pathology of the puberty and is accompanied by obesity in 39 % of adolescent girls. Obesity is one of the main causes of reproductive function disorders leading to decrease infertility in women. The aim of the study is to assess the gynecological health of...
| Main Authors: | , , |
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| Format: | Article |
| Language: | Russian |
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Scientific Сentre for Family Health and Human Reproduction Problems
2017-09-01
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| Series: | Acta Biomedica Scientifica |
| Subjects: | |
| Online Access: | https://www.actabiomedica.ru/jour/article/view/426 |
| _version_ | 1797237352509210624 |
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| author | I. V. Zhukovets O. Ya. Leshchenko A. V. Atalyan |
| author_facet | I. V. Zhukovets O. Ya. Leshchenko A. V. Atalyan |
| author_sort | I. V. Zhukovets |
| collection | DOAJ |
| description | Hypothalamic dysfunction is the most common pathology of the puberty and is accompanied by obesity in 39 % of adolescent girls. Obesity is one of the main causes of reproductive function disorders leading to decrease infertility in women. The aim of the study is to assess the gynecological health of reproductive age women with hypothalamic dysfunction in puberty and to determine the mechanisms of the primary infertility formation. We conducted a prospective study of adolescent girls with hypothalamic dysfunction (n = 170) from 2000 to 2013 year. According to the screening criteria, fertility was assessed in 86 women of reproductive age, a comparative characteristic was performed in fertile women (n = 46) and in women with primary infertility (n = 21). PCOS (38.1 %), absence of ayellow body in one of the ovaries (71.4 %), a decrease in serum progesterone by 2 times, an increase in ERa/PGR by 2.3 times and activity of NF-kB by 1.4 times in the endometrium were detected significantly more often in women with primary infertility with hypothalamic dysfunction in puberty in comparison with fertile women. The level of ERa and PGR in the endometrium decreased with increasing activity of NF-kB and BMI. The relationship between the activity of NF-kB and BMI in both study groups was established. |
| first_indexed | 2024-03-08T12:18:11Z |
| format | Article |
| id | doaj.art-a2405ad9d0bc4cd9be820e172cbe4090 |
| institution | Directory Open Access Journal |
| issn | 2541-9420 2587-9596 |
| language | Russian |
| last_indexed | 2024-04-24T17:18:23Z |
| publishDate | 2017-09-01 |
| publisher | Scientific Сentre for Family Health and Human Reproduction Problems |
| record_format | Article |
| series | Acta Biomedica Scientifica |
| spelling | doaj.art-a2405ad9d0bc4cd9be820e172cbe40902024-03-28T07:49:18ZrusScientific Сentre for Family Health and Human Reproduction ProblemsActa Biomedica Scientifica2541-94202587-95962017-09-0125(1)151910.12737/article_59e8bd5104ac02.59665046426Basic mechanisms of primary infertility in reproductive age women with hypothalamic dysfunction in pubertyI. V. Zhukovets0O. Ya. Leshchenko1A. V. Atalyan2Scientific Centre for Family Health and Human Reproduction Problems; Amur State Medical AcademyScientific Centre for Family Health and Human Reproduction ProblemsScientific Centre for Family Health and Human Reproduction ProblemsHypothalamic dysfunction is the most common pathology of the puberty and is accompanied by obesity in 39 % of adolescent girls. Obesity is one of the main causes of reproductive function disorders leading to decrease infertility in women. The aim of the study is to assess the gynecological health of reproductive age women with hypothalamic dysfunction in puberty and to determine the mechanisms of the primary infertility formation. We conducted a prospective study of adolescent girls with hypothalamic dysfunction (n = 170) from 2000 to 2013 year. According to the screening criteria, fertility was assessed in 86 women of reproductive age, a comparative characteristic was performed in fertile women (n = 46) and in women with primary infertility (n = 21). PCOS (38.1 %), absence of ayellow body in one of the ovaries (71.4 %), a decrease in serum progesterone by 2 times, an increase in ERa/PGR by 2.3 times and activity of NF-kB by 1.4 times in the endometrium were detected significantly more often in women with primary infertility with hypothalamic dysfunction in puberty in comparison with fertile women. The level of ERa and PGR in the endometrium decreased with increasing activity of NF-kB and BMI. The relationship between the activity of NF-kB and BMI in both study groups was established.https://www.actabiomedica.ru/jour/article/view/426erapgrnf-kвhypothalamic dysfunctionerapgrnf-kbendometriumprimary infertility |
| spellingShingle | I. V. Zhukovets O. Ya. Leshchenko A. V. Atalyan Basic mechanisms of primary infertility in reproductive age women with hypothalamic dysfunction in puberty Acta Biomedica Scientifica era pgr nf-kв hypothalamic dysfunction era pgr nf-kb endometrium primary infertility |
| title | Basic mechanisms of primary infertility in reproductive age women with hypothalamic dysfunction in puberty |
| title_full | Basic mechanisms of primary infertility in reproductive age women with hypothalamic dysfunction in puberty |
| title_fullStr | Basic mechanisms of primary infertility in reproductive age women with hypothalamic dysfunction in puberty |
| title_full_unstemmed | Basic mechanisms of primary infertility in reproductive age women with hypothalamic dysfunction in puberty |
| title_short | Basic mechanisms of primary infertility in reproductive age women with hypothalamic dysfunction in puberty |
| title_sort | basic mechanisms of primary infertility in reproductive age women with hypothalamic dysfunction in puberty |
| topic | era pgr nf-kв hypothalamic dysfunction era pgr nf-kb endometrium primary infertility |
| url | https://www.actabiomedica.ru/jour/article/view/426 |
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