Exploring the Potential of Cannabinoid Nanodelivery Systems for CNS Disorders
Cannabinoids have a major therapeutic value in a variety of disorders. The concepts of cannabinoids are difficult to develop, but they can be used and are advantageous for a number of diseases that are not sufficiently managed by existing treatments. Nanoconjugation and encapsulation techniques have...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-01-01
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| Series: | Pharmaceutics |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1999-4923/15/1/204 |
| _version_ | 1797437793612333056 |
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| author | Mariana Kolesarova Patrik Simko Nicol Urbanska Terezia Kiskova |
| author_facet | Mariana Kolesarova Patrik Simko Nicol Urbanska Terezia Kiskova |
| author_sort | Mariana Kolesarova |
| collection | DOAJ |
| description | Cannabinoids have a major therapeutic value in a variety of disorders. The concepts of cannabinoids are difficult to develop, but they can be used and are advantageous for a number of diseases that are not sufficiently managed by existing treatments. Nanoconjugation and encapsulation techniques have been shown to be effective in improving the delivery and the therapeutic effectiveness of drugs that are poorly soluble in water. Because the bioavailability of cannabinoids is low, the challenge is to explore different administration methods to improve their effectiveness. Because cannabinoids cross the blood-brain-barrier (BBB), they modify the negative effects of inflammatory processes on the BBB and may be a key factor in the improvement of BBB function after ischemic disease or other conditions. This review discusses various types of cannabinoid administration, as well as nanotechnologies used to improve the bioavailability of these compounds in CNS diseases. |
| first_indexed | 2024-03-09T11:27:46Z |
| format | Article |
| id | doaj.art-a242faf0a972489e8219e1ec8e595045 |
| institution | Directory Open Access Journal |
| issn | 1999-4923 |
| language | English |
| last_indexed | 2024-03-09T11:27:46Z |
| publishDate | 2023-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceutics |
| spelling | doaj.art-a242faf0a972489e8219e1ec8e5950452023-11-30T23:59:09ZengMDPI AGPharmaceutics1999-49232023-01-0115120410.3390/pharmaceutics15010204Exploring the Potential of Cannabinoid Nanodelivery Systems for CNS DisordersMariana Kolesarova0Patrik Simko1Nicol Urbanska2Terezia Kiskova3Institute of Biology and Ecology, Faculty of Science, Pavol Jozef Safarik University in Kosice, 040 01 Kosice, SlovakiaInstitute of Biology and Ecology, Faculty of Science, Pavol Jozef Safarik University in Kosice, 040 01 Kosice, SlovakiaInstitute of Biology and Ecology, Faculty of Science, Pavol Jozef Safarik University in Kosice, 040 01 Kosice, SlovakiaInstitute of Biology and Ecology, Faculty of Science, Pavol Jozef Safarik University in Kosice, 040 01 Kosice, SlovakiaCannabinoids have a major therapeutic value in a variety of disorders. The concepts of cannabinoids are difficult to develop, but they can be used and are advantageous for a number of diseases that are not sufficiently managed by existing treatments. Nanoconjugation and encapsulation techniques have been shown to be effective in improving the delivery and the therapeutic effectiveness of drugs that are poorly soluble in water. Because the bioavailability of cannabinoids is low, the challenge is to explore different administration methods to improve their effectiveness. Because cannabinoids cross the blood-brain-barrier (BBB), they modify the negative effects of inflammatory processes on the BBB and may be a key factor in the improvement of BBB function after ischemic disease or other conditions. This review discusses various types of cannabinoid administration, as well as nanotechnologies used to improve the bioavailability of these compounds in CNS diseases.https://www.mdpi.com/1999-4923/15/1/204nanoparticleslipidscannabinoidsTHCCBDneurodegenerative diseases |
| spellingShingle | Mariana Kolesarova Patrik Simko Nicol Urbanska Terezia Kiskova Exploring the Potential of Cannabinoid Nanodelivery Systems for CNS Disorders Pharmaceutics nanoparticles lipids cannabinoids THC CBD neurodegenerative diseases |
| title | Exploring the Potential of Cannabinoid Nanodelivery Systems for CNS Disorders |
| title_full | Exploring the Potential of Cannabinoid Nanodelivery Systems for CNS Disorders |
| title_fullStr | Exploring the Potential of Cannabinoid Nanodelivery Systems for CNS Disorders |
| title_full_unstemmed | Exploring the Potential of Cannabinoid Nanodelivery Systems for CNS Disorders |
| title_short | Exploring the Potential of Cannabinoid Nanodelivery Systems for CNS Disorders |
| title_sort | exploring the potential of cannabinoid nanodelivery systems for cns disorders |
| topic | nanoparticles lipids cannabinoids THC CBD neurodegenerative diseases |
| url | https://www.mdpi.com/1999-4923/15/1/204 |
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