Retrograde fibroblast growth factor 22 (FGF22) signaling regulates insulin-like growth factor 2 (IGF2) expression for activity-dependent synapse stabilization in the mammalian brain

Retrograde fibroblast growth factor 22 (FGF22) signaling regulates insulin-like growth factor 2 (IGF2) expression for activity-dependent synapse stabilization in the mammalian brain

Communication between pre- and postsynaptic cells promotes the initial organization of synaptic specializations, but subsequent synaptic stabilization requires transcriptional regulation. Here we show that fibroblast growth factor 22 (FGF22), a target-derived presynaptic organizer in the mouse hippo...

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Bibliographic Details
Main Authors: Akiko Terauchi, Erin M Johnson-Venkatesh, Brenna Bullock, Maria K Lehtinen, Hisashi Umemori
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2016-04-01
Series:eLife
Subjects:
synaptic stabilization
feedback signaling
neural activity
presynaptic organizer
transcriptional regulation
hippocampus
Online Access:https://elifesciences.org/articles/12151

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