Periodontal Disease, Local and Systemic Inflammation in Puerto Ricans with Type 2 Diabetes Mellitus
Periodontal disease (PD) is prevalent in type 2 diabetic condition (T2DM). Objectives: We assessed the associations between serum or gingival crevicular fluid (GCF) endothelial and inflammatory mediators and chronic PD among T2DM Hispanic adults. Methods: We enrolled 248 Puerto Rican residents with...
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MDPI AG
2023-10-01
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| Series: | Biomedicines |
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| Online Access: | https://www.mdpi.com/2227-9059/11/10/2770 |
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| author | Oelisoa M. Andriankaja Reuben Adatorwovor Alpdogan Kantarci Hatice Hasturk Luciana Shaddox Michael A. Levine |
| author_facet | Oelisoa M. Andriankaja Reuben Adatorwovor Alpdogan Kantarci Hatice Hasturk Luciana Shaddox Michael A. Levine |
| author_sort | Oelisoa M. Andriankaja |
| collection | DOAJ |
| description | Periodontal disease (PD) is prevalent in type 2 diabetic condition (T2DM). Objectives: We assessed the associations between serum or gingival crevicular fluid (GCF) endothelial and inflammatory mediators and chronic PD among T2DM Hispanic adults. Methods: We enrolled 248 Puerto Rican residents with T2DM aged 40–65 years. The exposures included serum inflammatory mediators (IL-1b, IL-6, IL-10, and TNF-α), endothelial adhesion molecules, RANKL levels, and the GCF content of these analytes from a subset of 158 samples. The outcomes included the percent of sites with a probing pocket depth (PPD) ≥ 4 mm and clinical attachment loss ≥ 4 mm. Adjusted logistic regression models were fit to the categorized outcomes. Results: Increased serum IL-10 (Adj. OR: 1.10, <i>p</i> = 0.04), sICAM-1 (Adj. OR: 1.01; <i>p</i> = 0.06), and elevated serum IL-1β (Adj. OR: 1.93; <i>p</i> = 0.06) were statistically significant or close to being significantly associated with a percent of sites with PPD ≥ 4 mm. An increase in GCF IL-1α (Adj. OR: 1.16; <i>p</i> < 0.01) and IL-1β (Adj: 2.40; <i>p</i> = 0.02) was associated with periodontal parameters. Conclusions: Our findings suggested that oral and systemic endothelial and inflammatory mediators are associated with periodontal clinical parameters among Hispanic adults with T2DM. |
| first_indexed | 2024-03-10T21:24:42Z |
| format | Article |
| id | doaj.art-a2442b064a5e4858936ee19ed3f840ee |
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| issn | 2227-9059 |
| language | English |
| last_indexed | 2024-03-10T21:24:42Z |
| publishDate | 2023-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomedicines |
| spelling | doaj.art-a2442b064a5e4858936ee19ed3f840ee2023-11-19T15:46:51ZengMDPI AGBiomedicines2227-90592023-10-011110277010.3390/biomedicines11102770Periodontal Disease, Local and Systemic Inflammation in Puerto Ricans with Type 2 Diabetes MellitusOelisoa M. Andriankaja0Reuben Adatorwovor1Alpdogan Kantarci2Hatice Hasturk3Luciana Shaddox4Michael A. Levine5Center for Oral Health Research (COHR), University of Kentucky College of Dentistry, Lexington, KY 40536, USACollege of Public Health, University of Kentucky, Lexington, KY 40536, USAThe Forsyth Institute, Cambridge, MA 02142, USACenter for Clinical and Translational Research, The Forsyth Institute, Cambridge, MA 02142, USACenter for Oral Health Research (COHR), University of Kentucky College of Dentistry, Lexington, KY 40536, USACenter for Bone Health, Division of Endocrinology and Diabetes, Children’s Hospital of Philadelphia, Philadelphia, PA 19104, USAPeriodontal disease (PD) is prevalent in type 2 diabetic condition (T2DM). Objectives: We assessed the associations between serum or gingival crevicular fluid (GCF) endothelial and inflammatory mediators and chronic PD among T2DM Hispanic adults. Methods: We enrolled 248 Puerto Rican residents with T2DM aged 40–65 years. The exposures included serum inflammatory mediators (IL-1b, IL-6, IL-10, and TNF-α), endothelial adhesion molecules, RANKL levels, and the GCF content of these analytes from a subset of 158 samples. The outcomes included the percent of sites with a probing pocket depth (PPD) ≥ 4 mm and clinical attachment loss ≥ 4 mm. Adjusted logistic regression models were fit to the categorized outcomes. Results: Increased serum IL-10 (Adj. OR: 1.10, <i>p</i> = 0.04), sICAM-1 (Adj. OR: 1.01; <i>p</i> = 0.06), and elevated serum IL-1β (Adj. OR: 1.93; <i>p</i> = 0.06) were statistically significant or close to being significantly associated with a percent of sites with PPD ≥ 4 mm. An increase in GCF IL-1α (Adj. OR: 1.16; <i>p</i> < 0.01) and IL-1β (Adj: 2.40; <i>p</i> = 0.02) was associated with periodontal parameters. Conclusions: Our findings suggested that oral and systemic endothelial and inflammatory mediators are associated with periodontal clinical parameters among Hispanic adults with T2DM.https://www.mdpi.com/2227-9059/11/10/2770periodontitiscytokinesendotheliumdiabetes mellitusinflammation |
| spellingShingle | Oelisoa M. Andriankaja Reuben Adatorwovor Alpdogan Kantarci Hatice Hasturk Luciana Shaddox Michael A. Levine Periodontal Disease, Local and Systemic Inflammation in Puerto Ricans with Type 2 Diabetes Mellitus Biomedicines periodontitis cytokines endothelium diabetes mellitus inflammation |
| title | Periodontal Disease, Local and Systemic Inflammation in Puerto Ricans with Type 2 Diabetes Mellitus |
| title_full | Periodontal Disease, Local and Systemic Inflammation in Puerto Ricans with Type 2 Diabetes Mellitus |
| title_fullStr | Periodontal Disease, Local and Systemic Inflammation in Puerto Ricans with Type 2 Diabetes Mellitus |
| title_full_unstemmed | Periodontal Disease, Local and Systemic Inflammation in Puerto Ricans with Type 2 Diabetes Mellitus |
| title_short | Periodontal Disease, Local and Systemic Inflammation in Puerto Ricans with Type 2 Diabetes Mellitus |
| title_sort | periodontal disease local and systemic inflammation in puerto ricans with type 2 diabetes mellitus |
| topic | periodontitis cytokines endothelium diabetes mellitus inflammation |
| url | https://www.mdpi.com/2227-9059/11/10/2770 |
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