Surgical palliation in poorly differentiated neuroendocrine carcinoma of the hypopharynx: Case report
Abstract Background Primary neuroendocrine carcinomas (NECs) are very rare entities accounting for 0.49% of all malignancies. Within the head and neck, the most common sites are the larynx and paranasal sinuses, while the hypopharynx is seldom described. Case We present a patient with a poorly diffe...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2022-08-01
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| Series: | Cancer Reports |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/cnr2.1558 |
| _version_ | 1811221234241765376 |
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| author | Francesca Romana Fiorini Yasmin Abbas Suchana Mukhopadhyay Taran Tatla |
| author_facet | Francesca Romana Fiorini Yasmin Abbas Suchana Mukhopadhyay Taran Tatla |
| author_sort | Francesca Romana Fiorini |
| collection | DOAJ |
| description | Abstract Background Primary neuroendocrine carcinomas (NECs) are very rare entities accounting for 0.49% of all malignancies. Within the head and neck, the most common sites are the larynx and paranasal sinuses, while the hypopharynx is seldom described. Case We present a patient with a poorly differentiated metastatic NEC of the hypopharynx treated palliatively with organ‐preserving surgery and post‐operative chemotherapy, and literature review for well‐documented pure hypopharyngeal NECs. Our patient died of chest infection during chemotherapy, 4 months after surgery. Conclusion Chemotherapy remains the mainstay of treatment in the presence of metastases with 2‐year overall survival of 15.7%. Due to the aggressive nature of poorly differentiated metastatic NECs, surgical management is seldom considered. We report and advocate the successful palliative role of organ‐preserving, minimally invasive trans‐oral LASER micro‐surgery and neck dissection to control loco‐regional head and neck disease, safe‐guarding better quality of home life, despite limited life expectancy for this condition. |
| first_indexed | 2024-04-12T07:55:55Z |
| format | Article |
| id | doaj.art-a2454deae75646d083741e804be9a008 |
| institution | Directory Open Access Journal |
| issn | 2573-8348 |
| language | English |
| last_indexed | 2024-04-12T07:55:55Z |
| publishDate | 2022-08-01 |
| publisher | Wiley |
| record_format | Article |
| series | Cancer Reports |
| spelling | doaj.art-a2454deae75646d083741e804be9a0082022-12-22T03:41:30ZengWileyCancer Reports2573-83482022-08-0158n/an/a10.1002/cnr2.1558Surgical palliation in poorly differentiated neuroendocrine carcinoma of the hypopharynx: Case reportFrancesca Romana Fiorini0Yasmin Abbas1Suchana Mukhopadhyay2Taran Tatla3Departmentof Otolaryngology and Head and Neck Northwick Park Hospital London UKDepartmentof Otolaryngology and Head and Neck Northwick Park Hospital London UKDepartmentof Otolaryngology and Head and Neck Northwick Park Hospital London UKDepartmentof Otolaryngology and Head and Neck Northwick Park Hospital London UKAbstract Background Primary neuroendocrine carcinomas (NECs) are very rare entities accounting for 0.49% of all malignancies. Within the head and neck, the most common sites are the larynx and paranasal sinuses, while the hypopharynx is seldom described. Case We present a patient with a poorly differentiated metastatic NEC of the hypopharynx treated palliatively with organ‐preserving surgery and post‐operative chemotherapy, and literature review for well‐documented pure hypopharyngeal NECs. Our patient died of chest infection during chemotherapy, 4 months after surgery. Conclusion Chemotherapy remains the mainstay of treatment in the presence of metastases with 2‐year overall survival of 15.7%. Due to the aggressive nature of poorly differentiated metastatic NECs, surgical management is seldom considered. We report and advocate the successful palliative role of organ‐preserving, minimally invasive trans‐oral LASER micro‐surgery and neck dissection to control loco‐regional head and neck disease, safe‐guarding better quality of home life, despite limited life expectancy for this condition.https://doi.org/10.1002/cnr2.1558hypopharynxneuroendocrine carcinomasurgical palliation |
| spellingShingle | Francesca Romana Fiorini Yasmin Abbas Suchana Mukhopadhyay Taran Tatla Surgical palliation in poorly differentiated neuroendocrine carcinoma of the hypopharynx: Case report Cancer Reports hypopharynx neuroendocrine carcinoma surgical palliation |
| title | Surgical palliation in poorly differentiated neuroendocrine carcinoma of the hypopharynx: Case report |
| title_full | Surgical palliation in poorly differentiated neuroendocrine carcinoma of the hypopharynx: Case report |
| title_fullStr | Surgical palliation in poorly differentiated neuroendocrine carcinoma of the hypopharynx: Case report |
| title_full_unstemmed | Surgical palliation in poorly differentiated neuroendocrine carcinoma of the hypopharynx: Case report |
| title_short | Surgical palliation in poorly differentiated neuroendocrine carcinoma of the hypopharynx: Case report |
| title_sort | surgical palliation in poorly differentiated neuroendocrine carcinoma of the hypopharynx case report |
| topic | hypopharynx neuroendocrine carcinoma surgical palliation |
| url | https://doi.org/10.1002/cnr2.1558 |
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