Synthesis and tyrosinase inhibitory activities of novel isopropylquinazolinones

Synthesis and tyrosinase inhibitory activities of novel isopropylquinazolinones

Abstract To find new anti-browning and whitening agents in this study, new series of isopropylquinazolinone derivatives were designed and synthesized. All derivatives were evaluated as possible tyrosinase inhibitors and compound 9q bearing 4-fluorobenzyl moieties at the R position exhibited the best...

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Bibliographic Details
Main Authors: Arshia Hashemi, Milad Noori, Navid Dastyafteh, Seyed Esmaeil Sadat-Ebrahimi, Negin Fazelzadeh Haghighi, Katayoun Mehrpour, Elahe Sattarinezhad, Fatemeh Jalali Zafrei, Cambyz Irajie, Mohammad Ali Daneshmehr, Majid Heydari, Bagher Larijani, Aida Iraji, Mohammad Mahdavi
Format: Article
Language:English
Published: BMC 2023-06-01
Series:BMC Chemistry
Subjects:
Isopropylquinazolinone
Synthesise
Tyrosinase
Enzyme inhibition
Kinetic evaluation
In silico studies
Online Access:https://doi.org/10.1186/s13065-023-00978-3

Internet

https://doi.org/10.1186/s13065-023-00978-3

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