Calycophyllum spruceanum (Benth.), the Amazonian “Tree of Youth” Prolongs Longevity and Enhances Stress Resistance in Caenorhabditis elegans
The tree popularly known in Brazil as mulateiro or pau-mulato (Calycophyllum spruceanum (Benth.) K. Schum.) is deeply embedded in the herbal medicine of the Amazon region. Different preparations of the bark are claimed to have anti-aging, antioxidant, antimicrobial, emollient, wound healing, hemosta...
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| Format: | Article |
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MDPI AG
2018-02-01
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| Series: | Molecules |
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| Online Access: | http://www.mdpi.com/1420-3049/23/3/534 |
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| author | Herbenya Peixoto Mariana Roxo Hector Koolen Felipe da Silva Emerson Silva Markus Santhosh Braun Xiaojuan Wang Michael Wink |
| author_facet | Herbenya Peixoto Mariana Roxo Hector Koolen Felipe da Silva Emerson Silva Markus Santhosh Braun Xiaojuan Wang Michael Wink |
| author_sort | Herbenya Peixoto |
| collection | DOAJ |
| description | The tree popularly known in Brazil as mulateiro or pau-mulato (Calycophyllum spruceanum (Benth.) K. Schum.) is deeply embedded in the herbal medicine of the Amazon region. Different preparations of the bark are claimed to have anti-aging, antioxidant, antimicrobial, emollient, wound healing, hemostatic, contraceptive, stimulant, and anti-diabetic properties. The current study aims to provide the first step towards a science-based evidence of the beneficial effects of C. spruceanum in the promotion of longevity and in the modulation of age-related markers. For this investigation, we used the model system Caenorhabditis elegans to evaluate in vivo antioxidant and anti-aging activity of a water extract from C. spruceanum. To chemically characterize the extract, HPLC MS (High Performance Liquid Chromatography Mass Spectrometry)/MS analyses were performed. Five secondary metabolites were identified in the extract, namely gardenoside, 5-hydroxymorin, cyanidin, taxifolin, and 5-hydroxy-6-methoxycoumarin-7-glucoside. C. spruceanum extract was able to enhance stress resistance and to extend lifespan along with attenuation of aging-associated markers in C. elegans. The demonstrated bioactivities apparently depend on the DAF-16/FOXO pathway. The data might support the popular claims of mulateiro as the “tree of youth”, however more studies are needed to clarify its putative benefits to human health. |
| first_indexed | 2024-12-12T21:11:12Z |
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| id | doaj.art-a24734868d4648ce9620bf0d9761269a |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-12-12T21:11:12Z |
| publishDate | 2018-02-01 |
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| series | Molecules |
| spelling | doaj.art-a24734868d4648ce9620bf0d9761269a2022-12-22T00:11:53ZengMDPI AGMolecules1420-30492018-02-0123353410.3390/molecules23030534molecules23030534Calycophyllum spruceanum (Benth.), the Amazonian “Tree of Youth” Prolongs Longevity and Enhances Stress Resistance in Caenorhabditis elegansHerbenya Peixoto0Mariana Roxo1Hector Koolen2Felipe da Silva3Emerson Silva4Markus Santhosh Braun5Xiaojuan Wang6Michael Wink7Institute of Pharmacy and Molecular Biotechnology, Heidelberg University, INF 364, D-69120 Heidelberg, GermanyInstitute of Pharmacy and Molecular Biotechnology, Heidelberg University, INF 364, D-69120 Heidelberg, GermanyMetabolomics and Mass Spectrometry Research Group, Amazonas State University (UEA), Manaus 690065-130, BrazilDepartment of Chemistry, Federal University of Amazonas (UFAM), 6200 General Rodrigo, Manaus 69077-000, BrazilFaculty of Pharmaceutical Science, Federal University of Amazonas (UFAM), 6200 General Rodrigo, Manaus 69077-000, BrazilInstitute of Pharmacy and Molecular Biotechnology, Heidelberg University, INF 364, D-69120 Heidelberg, GermanyInstitute of Pharmacy and Molecular Biotechnology, Heidelberg University, INF 364, D-69120 Heidelberg, GermanyInstitute of Pharmacy and Molecular Biotechnology, Heidelberg University, INF 364, D-69120 Heidelberg, GermanyThe tree popularly known in Brazil as mulateiro or pau-mulato (Calycophyllum spruceanum (Benth.) K. Schum.) is deeply embedded in the herbal medicine of the Amazon region. Different preparations of the bark are claimed to have anti-aging, antioxidant, antimicrobial, emollient, wound healing, hemostatic, contraceptive, stimulant, and anti-diabetic properties. The current study aims to provide the first step towards a science-based evidence of the beneficial effects of C. spruceanum in the promotion of longevity and in the modulation of age-related markers. For this investigation, we used the model system Caenorhabditis elegans to evaluate in vivo antioxidant and anti-aging activity of a water extract from C. spruceanum. To chemically characterize the extract, HPLC MS (High Performance Liquid Chromatography Mass Spectrometry)/MS analyses were performed. Five secondary metabolites were identified in the extract, namely gardenoside, 5-hydroxymorin, cyanidin, taxifolin, and 5-hydroxy-6-methoxycoumarin-7-glucoside. C. spruceanum extract was able to enhance stress resistance and to extend lifespan along with attenuation of aging-associated markers in C. elegans. The demonstrated bioactivities apparently depend on the DAF-16/FOXO pathway. The data might support the popular claims of mulateiro as the “tree of youth”, however more studies are needed to clarify its putative benefits to human health.http://www.mdpi.com/1420-3049/23/3/534Caenorhabditis elegansantioxidantsoxidative stressagingCalycophyllum spruceanum |
| spellingShingle | Herbenya Peixoto Mariana Roxo Hector Koolen Felipe da Silva Emerson Silva Markus Santhosh Braun Xiaojuan Wang Michael Wink Calycophyllum spruceanum (Benth.), the Amazonian “Tree of Youth” Prolongs Longevity and Enhances Stress Resistance in Caenorhabditis elegans Molecules Caenorhabditis elegans antioxidants oxidative stress aging Calycophyllum spruceanum |
| title | Calycophyllum spruceanum (Benth.), the Amazonian “Tree of Youth” Prolongs Longevity and Enhances Stress Resistance in Caenorhabditis elegans |
| title_full | Calycophyllum spruceanum (Benth.), the Amazonian “Tree of Youth” Prolongs Longevity and Enhances Stress Resistance in Caenorhabditis elegans |
| title_fullStr | Calycophyllum spruceanum (Benth.), the Amazonian “Tree of Youth” Prolongs Longevity and Enhances Stress Resistance in Caenorhabditis elegans |
| title_full_unstemmed | Calycophyllum spruceanum (Benth.), the Amazonian “Tree of Youth” Prolongs Longevity and Enhances Stress Resistance in Caenorhabditis elegans |
| title_short | Calycophyllum spruceanum (Benth.), the Amazonian “Tree of Youth” Prolongs Longevity and Enhances Stress Resistance in Caenorhabditis elegans |
| title_sort | calycophyllum spruceanum benth the amazonian tree of youth prolongs longevity and enhances stress resistance in caenorhabditis elegans |
| topic | Caenorhabditis elegans antioxidants oxidative stress aging Calycophyllum spruceanum |
| url | http://www.mdpi.com/1420-3049/23/3/534 |
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