Impact of Pneumococcal Vaccination in the Nasopharyngeal Carriage of Streptococcus pneumoniae in Healthy Children of the Murcia Region in Spain
Background: An epidemiological study of Streptococcus pneumoniae nasopharyngeal carriage in healthy children was carried out five years after the introduction of the 13-valent pneumococcal conjugate vaccine (PCV13). Objectives: Study the impact of pediatric vaccination with PCV13, and other associat...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-12-01
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| Series: | Vaccines |
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| Online Access: | https://www.mdpi.com/2076-393X/9/1/14 |
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| author | Santiago Alfayate Miguélez Genoveva Yague Guirao Ana I. Menasalvas Ruíz Manuel Sanchez-Solís Mirian Domenech Lucas Fernando González Camacho M. Mar Ortíz Romero Pilar Espejo García Carmen Guerrero Gómez Antonio Iofrío de Arce Laura Moreno Parrado Rosa M. Sánchez Andrada Eva Cascales Alcolea Sebastián Lorente García Pedro Paredes Reyes Ángela Casquet Barceló M. Luisa López Yepes Juan José Vigueras Abellán Gonzalo Sanz Mateo Murcian Pneumococcal Study Group |
| author_facet | Santiago Alfayate Miguélez Genoveva Yague Guirao Ana I. Menasalvas Ruíz Manuel Sanchez-Solís Mirian Domenech Lucas Fernando González Camacho M. Mar Ortíz Romero Pilar Espejo García Carmen Guerrero Gómez Antonio Iofrío de Arce Laura Moreno Parrado Rosa M. Sánchez Andrada Eva Cascales Alcolea Sebastián Lorente García Pedro Paredes Reyes Ángela Casquet Barceló M. Luisa López Yepes Juan José Vigueras Abellán Gonzalo Sanz Mateo Murcian Pneumococcal Study Group |
| author_sort | Santiago Alfayate Miguélez |
| collection | DOAJ |
| description | Background: An epidemiological study of Streptococcus pneumoniae nasopharyngeal carriage in healthy children was carried out five years after the introduction of the 13-valent pneumococcal conjugate vaccine (PCV13). Objectives: Study the impact of pediatric vaccination with PCV13, and other associated epidemiological factors on the status of nasopharyngeal carriage, the circulating pneumococcal serotypes, and the antibiotic susceptibility to more frequently used antibiotics. Methods: A multi-center study was carried out in Primary Health Care, which included 1821 healthy children aged 1 to 4 years old. All isolates were sent to the Spanish Pneumococcal Reference Laboratory for serotyping and antimicrobial susceptibility testing. Results: At least one dose of PCV13 had been received by 71.9% of children and carriage pneumococcal prevalence was 19.7%. The proportion of PCV13 serotypes was low (14.4%), with an observed predominance of non-vaccine serotypes, 23B, 11A, 10A, 35B/F, and 23A were the five most frequent. A high rate of resistance to penicillin, erythromycin, and trimethoprim sulfamethoxazole was found. Conclusions: A low proportion of PCV13 serotypes were detected, confirming the impact of pediatric vaccination for reducing the serotypes vaccine carriage. High resistance rates to clinically important antibiotics were observed. |
| first_indexed | 2024-03-10T13:43:45Z |
| format | Article |
| id | doaj.art-a2481573fa6e4bb289aefcf6bf6b2e37 |
| institution | Directory Open Access Journal |
| issn | 2076-393X |
| language | English |
| last_indexed | 2024-03-10T13:43:45Z |
| publishDate | 2020-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Vaccines |
| spelling | doaj.art-a2481573fa6e4bb289aefcf6bf6b2e372023-11-21T02:48:13ZengMDPI AGVaccines2076-393X2020-12-01911410.3390/vaccines9010014Impact of Pneumococcal Vaccination in the Nasopharyngeal Carriage of Streptococcus pneumoniae in Healthy Children of the Murcia Region in SpainSantiago Alfayate Miguélez0Genoveva Yague Guirao1Ana I. Menasalvas Ruíz2Manuel Sanchez-Solís3Mirian Domenech Lucas4Fernando González Camacho5M. Mar Ortíz Romero6Pilar Espejo García7Carmen Guerrero Gómez8Antonio Iofrío de Arce9Laura Moreno Parrado10Rosa M. Sánchez Andrada11Eva Cascales Alcolea12Sebastián Lorente García13Pedro Paredes Reyes14Ángela Casquet Barceló15M. Luisa López Yepes16Juan José Vigueras Abellán17Gonzalo Sanz Mateo18Murcian Pneumococcal Study GroupPediatrics Infectious Disease and Virgen de la Arrixaca Hospital, 30120 Murcia, SpainMicrobiology Department, Virgen de la Arrixaca Hospital, 30120 Murcia, SpainPediatrics Infectious Disease and Virgen de la Arrixaca Hospital, 30120 Murcia, SpainPediatrics Infectious Disease and Virgen de la Arrixaca Hospital, 30120 Murcia, SpainPneumoccocal Reference Laboratory CNM-ISCIII, 28220 Madrid, SpainPneumoccocal Reference Laboratory CNM-ISCIII, 28220 Madrid, SpainMicrobiology Department S, Lucía Hospital, 30202 Cartagena, SpainBarrio del Peral Health care Center, 30300 Cartagena, SpainMicrobiology Department Morales Meseguer Hospital, 30008 Murcia, SpainEl Ranero Health care Center, 30009 Murcia, SpainParrado Moreno L Los Arcos-Mar Menor Hospital, 30739 San Javier, SpainSan Javier Health care Center, 30730 San Javier, SpainMicrobiology Department Rafael Méndez Hospital, 30739 San Javier, SpainTotana Health care Center, 30850 Murcia, SapinMicrobiology Department, Virgen de la Arrixaca Hospital, 30120 Murcia, SpainRonda Sur. Health care Center, 30010 Murcia, SpainMicrobiology Department V del Castillo Hospital, 30510 Yecla, SpainPediatrician. Centro de Salud Mariano Yago, 30510 Yecla, SpainSanta María de Gracia Health care Center, 30009 Murcia, SpainBackground: An epidemiological study of Streptococcus pneumoniae nasopharyngeal carriage in healthy children was carried out five years after the introduction of the 13-valent pneumococcal conjugate vaccine (PCV13). Objectives: Study the impact of pediatric vaccination with PCV13, and other associated epidemiological factors on the status of nasopharyngeal carriage, the circulating pneumococcal serotypes, and the antibiotic susceptibility to more frequently used antibiotics. Methods: A multi-center study was carried out in Primary Health Care, which included 1821 healthy children aged 1 to 4 years old. All isolates were sent to the Spanish Pneumococcal Reference Laboratory for serotyping and antimicrobial susceptibility testing. Results: At least one dose of PCV13 had been received by 71.9% of children and carriage pneumococcal prevalence was 19.7%. The proportion of PCV13 serotypes was low (14.4%), with an observed predominance of non-vaccine serotypes, 23B, 11A, 10A, 35B/F, and 23A were the five most frequent. A high rate of resistance to penicillin, erythromycin, and trimethoprim sulfamethoxazole was found. Conclusions: A low proportion of PCV13 serotypes were detected, confirming the impact of pediatric vaccination for reducing the serotypes vaccine carriage. High resistance rates to clinically important antibiotics were observed.https://www.mdpi.com/2076-393X/9/1/14Streptococcus pneumoniae nasopharyngeal carriageconjugate vaccinesantimicrobial susceptibility |
| spellingShingle | Santiago Alfayate Miguélez Genoveva Yague Guirao Ana I. Menasalvas Ruíz Manuel Sanchez-Solís Mirian Domenech Lucas Fernando González Camacho M. Mar Ortíz Romero Pilar Espejo García Carmen Guerrero Gómez Antonio Iofrío de Arce Laura Moreno Parrado Rosa M. Sánchez Andrada Eva Cascales Alcolea Sebastián Lorente García Pedro Paredes Reyes Ángela Casquet Barceló M. Luisa López Yepes Juan José Vigueras Abellán Gonzalo Sanz Mateo Murcian Pneumococcal Study Group Impact of Pneumococcal Vaccination in the Nasopharyngeal Carriage of Streptococcus pneumoniae in Healthy Children of the Murcia Region in Spain Vaccines Streptococcus pneumoniae nasopharyngeal carriage conjugate vaccines antimicrobial susceptibility |
| title | Impact of Pneumococcal Vaccination in the Nasopharyngeal Carriage of Streptococcus pneumoniae in Healthy Children of the Murcia Region in Spain |
| title_full | Impact of Pneumococcal Vaccination in the Nasopharyngeal Carriage of Streptococcus pneumoniae in Healthy Children of the Murcia Region in Spain |
| title_fullStr | Impact of Pneumococcal Vaccination in the Nasopharyngeal Carriage of Streptococcus pneumoniae in Healthy Children of the Murcia Region in Spain |
| title_full_unstemmed | Impact of Pneumococcal Vaccination in the Nasopharyngeal Carriage of Streptococcus pneumoniae in Healthy Children of the Murcia Region in Spain |
| title_short | Impact of Pneumococcal Vaccination in the Nasopharyngeal Carriage of Streptococcus pneumoniae in Healthy Children of the Murcia Region in Spain |
| title_sort | impact of pneumococcal vaccination in the nasopharyngeal carriage of streptococcus pneumoniae in healthy children of the murcia region in spain |
| topic | Streptococcus pneumoniae nasopharyngeal carriage conjugate vaccines antimicrobial susceptibility |
| url | https://www.mdpi.com/2076-393X/9/1/14 |
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