Chlorpromazine affects autophagy in association with altered Rag GTPase–mTORC1–TFEB signaling

Chlorpromazine affects autophagy in association with altered Rag GTPase–mTORC1–TFEB signaling

Autophagy is a critical protein and organelle quality control system, which regulates cellular homeostasis and survival. Growing pieces of evidence suggest that autophagic dysfunction is strongly associated with many human diseases, including neurological diseases and cancer. Among various autophagi...

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Bibliographic Details
Main Authors: Ningning Li, Lingling Rao, Xueqing Zhao, Junwen Shen, Dan Su, Guoqiang Ma, Shan Sun, Qilian Ma, Li Zhang, Chunsheng Dong, Kin Yip Tam, Jochen H. M. Prehn, Hongfeng Wang, Zheng Ying
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-09-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
CPZ
TFEB
autophagy
mTORC1
Rag GTPases
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2023.1266198/full

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