Genome-wide compensatory changes accompany drug- selected mutations in the Plasmodium falciparum crt gene.

Genome-wide compensatory changes accompany drug- selected mutations in the Plasmodium falciparum crt gene.

Mutations in PfCRT (Plasmodium falciparum chloroquine-resistant transporter), particularly the substitution at amino acid position 76, confer chloroquine (CQ) resistance in P. falciparum. Point mutations in the homolog of the mammalian multidrug resistance gene (pfmdr1) can also modulate the levels...

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Bibliographic Details
Main Authors: Hongying Jiang, Jigar J Patel, Ming Yi, Jianbing Mu, Jinhui Ding, Robert Stephens, Roland A Cooper, Michael T Ferdig, Xin-zhuan Su
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2008-06-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2424241?pdf=render

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