Intravenous infusion of the exosomes derived from human umbilical cord mesenchymal stem cells enhance neurological recovery after traumatic brain injury via suppressing the NF-κB pathway
Traumatic brain injury (TBI) is a predominant cause of death and permanent disability globally. In recent years, much emphasis has been laid on treatments for TBI. Increasing evidence suggests that human umbilical cord mesenchymal stem cells (HUCMSCs) can improve neurological repair after TBI. Howev...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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De Gruyter
2022-03-01
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| Series: | Open Life Sciences |
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| Online Access: | https://doi.org/10.1515/biol-2022-0022 |
| _version_ | 1797998123848564736 |
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| author | Zhang Zhen-Wen Wei Pan Zhang Gui-Jun Yan Jing-Xing Zhang Sai Liang Jin Wang Xiao-Li |
| author_facet | Zhang Zhen-Wen Wei Pan Zhang Gui-Jun Yan Jing-Xing Zhang Sai Liang Jin Wang Xiao-Li |
| author_sort | Zhang Zhen-Wen |
| collection | DOAJ |
| description | Traumatic brain injury (TBI) is a predominant cause of death and permanent disability globally. In recent years, much emphasis has been laid on treatments for TBI. Increasing evidence suggests that human umbilical cord mesenchymal stem cells (HUCMSCs) can improve neurological repair after TBI. However, the clinical use of HUCMSCs transplantation in TBI has been limited by immunological rejection, ethical issues, and the risk of tumorigenicity. Many studies have shown that HUCMSCs-derived exosomes may be an alternative approach for HUCMSCs transplantation. We hypothesized that exosomes derived from HUCMSCs could inhibit apoptosis after TBI, reduce neuroinflammation, and promote neurogenesis. A rat model of TBI was established to investigate the efficiency of neurological recovery with exosome therapy. We found that exosomes derived from HUCMSCs significantly ameliorated sensorimotor function and spatial learning in rats after TBI. Moreover, HUCMSCs-derived exosomes significantly reduced proinflammatory cytokine expression by suppressing the NF-κB signaling pathway. Furthermore, we found that HUCMSC-derived exosomes inhibited neuronal apoptosis, reduced inflammation, and promoted neuron regeneration in the injured cortex of rats after TBI. These results indicate that HUCMSCs-derived exosomes may be a promising therapeutic strategy for TBI. |
| first_indexed | 2024-04-11T10:43:32Z |
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| id | doaj.art-a24d6a84fcd949ecb91f37ecd6d280f9 |
| institution | Directory Open Access Journal |
| issn | 2391-5412 |
| language | English |
| last_indexed | 2024-04-11T10:43:32Z |
| publishDate | 2022-03-01 |
| publisher | De Gruyter |
| record_format | Article |
| series | Open Life Sciences |
| spelling | doaj.art-a24d6a84fcd949ecb91f37ecd6d280f92022-12-22T04:29:08ZengDe GruyterOpen Life Sciences2391-54122022-03-0117118920110.1515/biol-2022-0022Intravenous infusion of the exosomes derived from human umbilical cord mesenchymal stem cells enhance neurological recovery after traumatic brain injury via suppressing the NF-κB pathwayZhang Zhen-Wen0Wei Pan1Zhang Gui-Jun2Yan Jing-Xing3Zhang Sai4Liang Jin5Wang Xiao-Li6Department of Encephalopathy, Affiliated Hospital of Gansu University of Chinese Medicine, Lanzhou 730000, Gansu, ChinaDepartment of Neurosurgery, The First People’s Hospital of Long Quan Yi District, Cheng Du 610000, Si Chuan, ChinaDepartment of Neurosurgery, West China Medical School, West China Hospital, Sichuan University, Chengdu 610041, Sichuan, ChinaDepartment of Encephalopathy, Affiliated Hospital of Gansu University of Chinese Medicine, Lanzhou 730000, Gansu, ChinaTianjin Key Laboratory of Neurotrauma Repair, Pingjin Hospital Brain Center, Characteristic Medical Center of PAPF, Tianjin 300162, ChinaTianjin Key Laboratory of Neurotrauma Repair, Pingjin Hospital Brain Center, Characteristic Medical Center of PAPF, Tianjin 300162, ChinaTianjin Key Laboratory of Neurotrauma Repair, Pingjin Hospital Brain Center, Characteristic Medical Center of PAPF, Tianjin 300162, ChinaTraumatic brain injury (TBI) is a predominant cause of death and permanent disability globally. In recent years, much emphasis has been laid on treatments for TBI. Increasing evidence suggests that human umbilical cord mesenchymal stem cells (HUCMSCs) can improve neurological repair after TBI. However, the clinical use of HUCMSCs transplantation in TBI has been limited by immunological rejection, ethical issues, and the risk of tumorigenicity. Many studies have shown that HUCMSCs-derived exosomes may be an alternative approach for HUCMSCs transplantation. We hypothesized that exosomes derived from HUCMSCs could inhibit apoptosis after TBI, reduce neuroinflammation, and promote neurogenesis. A rat model of TBI was established to investigate the efficiency of neurological recovery with exosome therapy. We found that exosomes derived from HUCMSCs significantly ameliorated sensorimotor function and spatial learning in rats after TBI. Moreover, HUCMSCs-derived exosomes significantly reduced proinflammatory cytokine expression by suppressing the NF-κB signaling pathway. Furthermore, we found that HUCMSC-derived exosomes inhibited neuronal apoptosis, reduced inflammation, and promoted neuron regeneration in the injured cortex of rats after TBI. These results indicate that HUCMSCs-derived exosomes may be a promising therapeutic strategy for TBI.https://doi.org/10.1515/biol-2022-0022exosomeshuman umbilical cord mesenchymal stem cellsneurological recoverynf-κbtraumatic brain injury |
| spellingShingle | Zhang Zhen-Wen Wei Pan Zhang Gui-Jun Yan Jing-Xing Zhang Sai Liang Jin Wang Xiao-Li Intravenous infusion of the exosomes derived from human umbilical cord mesenchymal stem cells enhance neurological recovery after traumatic brain injury via suppressing the NF-κB pathway Open Life Sciences exosomes human umbilical cord mesenchymal stem cells neurological recovery nf-κb traumatic brain injury |
| title | Intravenous infusion of the exosomes derived from human umbilical cord mesenchymal stem cells enhance neurological recovery after traumatic brain injury via suppressing the NF-κB pathway |
| title_full | Intravenous infusion of the exosomes derived from human umbilical cord mesenchymal stem cells enhance neurological recovery after traumatic brain injury via suppressing the NF-κB pathway |
| title_fullStr | Intravenous infusion of the exosomes derived from human umbilical cord mesenchymal stem cells enhance neurological recovery after traumatic brain injury via suppressing the NF-κB pathway |
| title_full_unstemmed | Intravenous infusion of the exosomes derived from human umbilical cord mesenchymal stem cells enhance neurological recovery after traumatic brain injury via suppressing the NF-κB pathway |
| title_short | Intravenous infusion of the exosomes derived from human umbilical cord mesenchymal stem cells enhance neurological recovery after traumatic brain injury via suppressing the NF-κB pathway |
| title_sort | intravenous infusion of the exosomes derived from human umbilical cord mesenchymal stem cells enhance neurological recovery after traumatic brain injury via suppressing the nf κb pathway |
| topic | exosomes human umbilical cord mesenchymal stem cells neurological recovery nf-κb traumatic brain injury |
| url | https://doi.org/10.1515/biol-2022-0022 |
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