Dexmedetomidine May Produce Extra Protective Effects on Sepsis-induced Diaphragm Injury
Objective: The objective was to evaluate the protective effects of dexmedetomidine (DEX), a selective agonist of α2-adrenergic receptor, on sepsis-induced diaphragm injury and the underlying molecular mechanisms. Data Sources: The data used in this review were mainly from PubMed articles published...
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer
2015-01-01
|
| Series: | Chinese Medical Journal |
| Subjects: | |
| Online Access: | http://www.cmj.org/article.asp?issn=0366-6999;year=2015;volume=128;issue=10;spage=1407;epage=1411;aulast=Wu |
| _version_ | 1818678496932659200 |
|---|---|
| author | Jin Wu Shi-Tong Li |
| author_facet | Jin Wu Shi-Tong Li |
| author_sort | Jin Wu |
| collection | DOAJ |
| description | Objective: The objective was to evaluate the protective effects of dexmedetomidine (DEX), a selective agonist of α2-adrenergic receptor, on sepsis-induced diaphragm injury and the underlying molecular mechanisms.
Data Sources: The data used in this review were mainly from PubMed articles published in English from 1990 to 2015.
Study Selection: Clinical or basic research articles were selected mainly according to their level of relevance to this topic.
Results: Sepsis could induce severe diaphragm dysfunction and exacerbate respiratory weakness. The mechanism of sepsis-induced diaphragm injury includes the increased inflammatory cytokines and excessive oxidative stress and superfluous production of nitric oxide (NO). DEX can reduce inflammatory cytokines, inhibit nuclear factor-kappaB signaling pathways, suppress the activation of caspase-3, furthermore decrease oxidative stress and inhibit NO synthase. On the basis of these mechanisms, DEX may result in a shorter period of mechanical ventilation in septic patients in clinical practice.
Conclusions: Based on this current available evidence, DEX may produce extra protective effects on sepsis-induced diaphragm injury. Further direct evidence and more specific studies are still required to confirm these beneficial effects. |
| first_indexed | 2024-12-17T09:16:12Z |
| format | Article |
| id | doaj.art-a24da630e25a468f9dbc02c6d21bf294 |
| institution | Directory Open Access Journal |
| issn | 0366-6999 |
| language | English |
| last_indexed | 2024-12-17T09:16:12Z |
| publishDate | 2015-01-01 |
| publisher | Wolters Kluwer |
| record_format | Article |
| series | Chinese Medical Journal |
| spelling | doaj.art-a24da630e25a468f9dbc02c6d21bf2942022-12-21T21:54:59ZengWolters KluwerChinese Medical Journal0366-69992015-01-01128101407141110.4103/0366-6999.156808Dexmedetomidine May Produce Extra Protective Effects on Sepsis-induced Diaphragm InjuryJin WuShi-Tong LiObjective: The objective was to evaluate the protective effects of dexmedetomidine (DEX), a selective agonist of α2-adrenergic receptor, on sepsis-induced diaphragm injury and the underlying molecular mechanisms. Data Sources: The data used in this review were mainly from PubMed articles published in English from 1990 to 2015. Study Selection: Clinical or basic research articles were selected mainly according to their level of relevance to this topic. Results: Sepsis could induce severe diaphragm dysfunction and exacerbate respiratory weakness. The mechanism of sepsis-induced diaphragm injury includes the increased inflammatory cytokines and excessive oxidative stress and superfluous production of nitric oxide (NO). DEX can reduce inflammatory cytokines, inhibit nuclear factor-kappaB signaling pathways, suppress the activation of caspase-3, furthermore decrease oxidative stress and inhibit NO synthase. On the basis of these mechanisms, DEX may result in a shorter period of mechanical ventilation in septic patients in clinical practice. Conclusions: Based on this current available evidence, DEX may produce extra protective effects on sepsis-induced diaphragm injury. Further direct evidence and more specific studies are still required to confirm these beneficial effects.http://www.cmj.org/article.asp?issn=0366-6999;year=2015;volume=128;issue=10;spage=1407;epage=1411;aulast=WuDexmedetomidine; Diaphragm; Drug Effects; Sepsis |
| spellingShingle | Jin Wu Shi-Tong Li Dexmedetomidine May Produce Extra Protective Effects on Sepsis-induced Diaphragm Injury Chinese Medical Journal Dexmedetomidine; Diaphragm; Drug Effects; Sepsis |
| title | Dexmedetomidine May Produce Extra Protective Effects on Sepsis-induced Diaphragm Injury |
| title_full | Dexmedetomidine May Produce Extra Protective Effects on Sepsis-induced Diaphragm Injury |
| title_fullStr | Dexmedetomidine May Produce Extra Protective Effects on Sepsis-induced Diaphragm Injury |
| title_full_unstemmed | Dexmedetomidine May Produce Extra Protective Effects on Sepsis-induced Diaphragm Injury |
| title_short | Dexmedetomidine May Produce Extra Protective Effects on Sepsis-induced Diaphragm Injury |
| title_sort | dexmedetomidine may produce extra protective effects on sepsis induced diaphragm injury |
| topic | Dexmedetomidine; Diaphragm; Drug Effects; Sepsis |
| url | http://www.cmj.org/article.asp?issn=0366-6999;year=2015;volume=128;issue=10;spage=1407;epage=1411;aulast=Wu |
| work_keys_str_mv | AT jinwu dexmedetomidinemayproduceextraprotectiveeffectsonsepsisinduceddiaphragminjury AT shitongli dexmedetomidinemayproduceextraprotectiveeffectsonsepsisinduceddiaphragminjury |