Isolated Hematuria in SLE Patients and its Association with Proteinuria, Uri-nary Cast and SLE Disease Activity
Isolated hematuria and its association with proteinuria, and urinary cast and systemic lupus erythematosus (SLE) disease activity, and decision for renal biopsy is a dilemma for physician in SLE patients. The aim of this study was to investigate 1. whether isolated hematuria is associated with activ...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Tehran University of Medical Sciences
2009-02-01
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| Series: | Acta Medica Iranica |
| Subjects: | |
| Online Access: | https://acta.tums.ac.ir/index.php/acta/article/view/3534 |
| _version_ | 1818083276938543104 |
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| author | Mahmood Akbarian Hosein Soleymani Farhad Gharibdoost Abdolhadi Nadji Ahmad Reza Jamshidi Farhad Shahram Masoumeh Akhlaghi Shahrzad Khosravi Simin Almasi Fereydoun Davatchi |
| author_facet | Mahmood Akbarian Hosein Soleymani Farhad Gharibdoost Abdolhadi Nadji Ahmad Reza Jamshidi Farhad Shahram Masoumeh Akhlaghi Shahrzad Khosravi Simin Almasi Fereydoun Davatchi |
| author_sort | Mahmood Akbarian |
| collection | DOAJ |
| description | Isolated hematuria and its association with proteinuria, and urinary cast and systemic lupus erythematosus (SLE) disease activity, and decision for renal biopsy is a dilemma for physician in SLE patients. The aim of this study was to investigate 1. whether isolated hematuria is associated with active SLE, 2. to determine duration between hematuria and proteinuria and urinary cast, and 3. to determine renal histological type in SLE patients with isolated hematuria. All episodes of isolated hematuria between 1981 and 1997 were identified from Lupus Unit, Rheumatology Research Center database. Isolated hematuria was defined as >5 RBC/hpf in the absence of urinary infection and other renal manifestations. Relation of hematuria was assessed with proteinuria and urinary cast and SLE disease activity. Needle renal biopsy was done in 19 SLE patents with isolated hematuria. 4.42% (31/700) of our cohort had at least one episode of isolated hematuria. Out of 31 patients in whom the isolated hematuria was the first documented renal manifestation, 11 patients (35.48%) developed another renal manifestation (25.8% proteinuria and 9.67% casts). 54.54% (6/11) of patients developed proteinuria and urinary cast within 3 months. The mean time for development of a second renal manifestation for the patients with isolated hematuria was 19.9 months. Renal needle biopsy was performed for 19 patients (5.78% type IV, 63.15% type III and 21.50% type II). The results of the present study indicate that isolated hematuria is not rare in SLE patients. Also, there was no significant relationship between isolated hematuria and anti ds-DNA, C3, C4 and major organ involvement in patients with SLE. Our study suggests that SLE patients who have isolated hematuria should undergo renal biopsy and that isolated hematuria should be considered a manifestation of active renal SLE. |
| first_indexed | 2024-12-10T19:35:26Z |
| format | Article |
| id | doaj.art-a24f1592aeaf4f7890315d118dc41aa8 |
| institution | Directory Open Access Journal |
| issn | 0044-6025 1735-9694 |
| language | English |
| last_indexed | 2024-12-10T19:35:26Z |
| publishDate | 2009-02-01 |
| publisher | Tehran University of Medical Sciences |
| record_format | Article |
| series | Acta Medica Iranica |
| spelling | doaj.art-a24f1592aeaf4f7890315d118dc41aa82022-12-22T01:36:08ZengTehran University of Medical SciencesActa Medica Iranica0044-60251735-96942009-02-01471Isolated Hematuria in SLE Patients and its Association with Proteinuria, Uri-nary Cast and SLE Disease ActivityMahmood Akbarian0Hosein Soleymani1Farhad Gharibdoost2Abdolhadi Nadji3Ahmad Reza Jamshidi4Farhad Shahram5Masoumeh Akhlaghi6Shahrzad Khosravi7Simin Almasi8Fereydoun Davatchi9Department of Rheumatology, Shariati Hospital, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.Department of Rheumatology, Shariati Hospital, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.Department of Rheumatology, Shariati Hospital, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.Department of Rheumatology, Shariati Hospital, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.Department of Rheumatology, Shariati Hospital, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.Department of Rheumatology, Shariati Hospital, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.Department of Rheumatology, Shariati Hospital, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.Department of Rheumatology, Shariati Hospital, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.Department of Rheumatology, Shariati Hospital, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.Department of Rheumatology, Shariati Hospital, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.Isolated hematuria and its association with proteinuria, and urinary cast and systemic lupus erythematosus (SLE) disease activity, and decision for renal biopsy is a dilemma for physician in SLE patients. The aim of this study was to investigate 1. whether isolated hematuria is associated with active SLE, 2. to determine duration between hematuria and proteinuria and urinary cast, and 3. to determine renal histological type in SLE patients with isolated hematuria. All episodes of isolated hematuria between 1981 and 1997 were identified from Lupus Unit, Rheumatology Research Center database. Isolated hematuria was defined as >5 RBC/hpf in the absence of urinary infection and other renal manifestations. Relation of hematuria was assessed with proteinuria and urinary cast and SLE disease activity. Needle renal biopsy was done in 19 SLE patents with isolated hematuria. 4.42% (31/700) of our cohort had at least one episode of isolated hematuria. Out of 31 patients in whom the isolated hematuria was the first documented renal manifestation, 11 patients (35.48%) developed another renal manifestation (25.8% proteinuria and 9.67% casts). 54.54% (6/11) of patients developed proteinuria and urinary cast within 3 months. The mean time for development of a second renal manifestation for the patients with isolated hematuria was 19.9 months. Renal needle biopsy was performed for 19 patients (5.78% type IV, 63.15% type III and 21.50% type II). The results of the present study indicate that isolated hematuria is not rare in SLE patients. Also, there was no significant relationship between isolated hematuria and anti ds-DNA, C3, C4 and major organ involvement in patients with SLE. Our study suggests that SLE patients who have isolated hematuria should undergo renal biopsy and that isolated hematuria should be considered a manifestation of active renal SLE.https://acta.tums.ac.ir/index.php/acta/article/view/3534Isolated hematuriasystemic lupus erythematosusSLE disease activity |
| spellingShingle | Mahmood Akbarian Hosein Soleymani Farhad Gharibdoost Abdolhadi Nadji Ahmad Reza Jamshidi Farhad Shahram Masoumeh Akhlaghi Shahrzad Khosravi Simin Almasi Fereydoun Davatchi Isolated Hematuria in SLE Patients and its Association with Proteinuria, Uri-nary Cast and SLE Disease Activity Acta Medica Iranica Isolated hematuria systemic lupus erythematosus SLE disease activity |
| title | Isolated Hematuria in SLE Patients and its Association with Proteinuria, Uri-nary Cast and SLE Disease Activity |
| title_full | Isolated Hematuria in SLE Patients and its Association with Proteinuria, Uri-nary Cast and SLE Disease Activity |
| title_fullStr | Isolated Hematuria in SLE Patients and its Association with Proteinuria, Uri-nary Cast and SLE Disease Activity |
| title_full_unstemmed | Isolated Hematuria in SLE Patients and its Association with Proteinuria, Uri-nary Cast and SLE Disease Activity |
| title_short | Isolated Hematuria in SLE Patients and its Association with Proteinuria, Uri-nary Cast and SLE Disease Activity |
| title_sort | isolated hematuria in sle patients and its association with proteinuria uri nary cast and sle disease activity |
| topic | Isolated hematuria systemic lupus erythematosus SLE disease activity |
| url | https://acta.tums.ac.ir/index.php/acta/article/view/3534 |
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