Pancreatic Organoids: A Frontier Method for Investigating Pancreatic-Related Diseases
The pancreas represents an important organ that has not been comprehensively studied in many fields. To fill this gap, many models have been generated, and traditional models have shown good performance in addressing pancreatic-related diseases, but are increasingly struggling to keep up with the ne...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2023-02-01
|
| Series: | International Journal of Molecular Sciences |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1422-0067/24/4/4027 |
| _version_ | 1797620417855225856 |
|---|---|
| author | Yuxiang Liu Nianshuang Li Yin Zhu |
| author_facet | Yuxiang Liu Nianshuang Li Yin Zhu |
| author_sort | Yuxiang Liu |
| collection | DOAJ |
| description | The pancreas represents an important organ that has not been comprehensively studied in many fields. To fill this gap, many models have been generated, and traditional models have shown good performance in addressing pancreatic-related diseases, but are increasingly struggling to keep up with the need for further research due to ethical issues, genetic heterogeneity and difficult clinical translation. The new era calls for new and more reliable research models. Therefore, organoids have been proposed as a novel model for the evaluation of pancreatic-related diseases such as pancreatic malignancy, diabetes, and pancreatic cystic fibrosis. Compared with common traditional models, including 2D cell culture and gene editing mice, organoids derived from living humans or mice cause minimal harm to the donor, raise fewer ethical concerns, and reasonably address the claims of heterogeneity, which allows for the further development of pathogenesis studies and clinical trial analysis. In this review, we analyse studies on the use of pancreatic organoids in research on pancreatic-related diseases, discuss the advantages and disadvantages, and hypothesize future trends. |
| first_indexed | 2024-03-11T08:41:02Z |
| format | Article |
| id | doaj.art-a2522c62bfcb4a97ae70e2dcf1a6259c |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-11T08:41:02Z |
| publishDate | 2023-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-a2522c62bfcb4a97ae70e2dcf1a6259c2023-11-16T21:08:26ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672023-02-01244402710.3390/ijms24044027Pancreatic Organoids: A Frontier Method for Investigating Pancreatic-Related DiseasesYuxiang Liu0Nianshuang Li1Yin Zhu2Department of Gastroenterology, The First Affiliated Hospital of Nanchang University, Nanchang 330209, ChinaDepartment of Gastroenterology, The First Affiliated Hospital of Nanchang University, Nanchang 330209, ChinaDepartment of Gastroenterology, The First Affiliated Hospital of Nanchang University, Nanchang 330209, ChinaThe pancreas represents an important organ that has not been comprehensively studied in many fields. To fill this gap, many models have been generated, and traditional models have shown good performance in addressing pancreatic-related diseases, but are increasingly struggling to keep up with the need for further research due to ethical issues, genetic heterogeneity and difficult clinical translation. The new era calls for new and more reliable research models. Therefore, organoids have been proposed as a novel model for the evaluation of pancreatic-related diseases such as pancreatic malignancy, diabetes, and pancreatic cystic fibrosis. Compared with common traditional models, including 2D cell culture and gene editing mice, organoids derived from living humans or mice cause minimal harm to the donor, raise fewer ethical concerns, and reasonably address the claims of heterogeneity, which allows for the further development of pathogenesis studies and clinical trial analysis. In this review, we analyse studies on the use of pancreatic organoids in research on pancreatic-related diseases, discuss the advantages and disadvantages, and hypothesize future trends.https://www.mdpi.com/1422-0067/24/4/4027pancreatic organoidpancreatic cancerpersonalized medicinediabetespancreatic cystic fibrosis |
| spellingShingle | Yuxiang Liu Nianshuang Li Yin Zhu Pancreatic Organoids: A Frontier Method for Investigating Pancreatic-Related Diseases International Journal of Molecular Sciences pancreatic organoid pancreatic cancer personalized medicine diabetes pancreatic cystic fibrosis |
| title | Pancreatic Organoids: A Frontier Method for Investigating Pancreatic-Related Diseases |
| title_full | Pancreatic Organoids: A Frontier Method for Investigating Pancreatic-Related Diseases |
| title_fullStr | Pancreatic Organoids: A Frontier Method for Investigating Pancreatic-Related Diseases |
| title_full_unstemmed | Pancreatic Organoids: A Frontier Method for Investigating Pancreatic-Related Diseases |
| title_short | Pancreatic Organoids: A Frontier Method for Investigating Pancreatic-Related Diseases |
| title_sort | pancreatic organoids a frontier method for investigating pancreatic related diseases |
| topic | pancreatic organoid pancreatic cancer personalized medicine diabetes pancreatic cystic fibrosis |
| url | https://www.mdpi.com/1422-0067/24/4/4027 |
| work_keys_str_mv | AT yuxiangliu pancreaticorganoidsafrontiermethodforinvestigatingpancreaticrelateddiseases AT nianshuangli pancreaticorganoidsafrontiermethodforinvestigatingpancreaticrelateddiseases AT yinzhu pancreaticorganoidsafrontiermethodforinvestigatingpancreaticrelateddiseases |