The Pivotal Role of Oleuropein in the Anti-Diabetic Action of the Mediterranean Diet: A Concise Review
Type 2 diabetes currently accounts for more than 90% of all diabetic patients. Lifestyle interventions and notably dietary modifications are one of the mainstays for the prevention and treatment of type 2 diabetes. In this context, the Mediterranean diet with its elevated content of phytonutrients h...
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| Format: | Article |
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MDPI AG
2021-12-01
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| Series: | Pharmaceutics |
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| Online Access: | https://www.mdpi.com/1999-4923/14/1/40 |
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| author | Andrea Da Porto Gabriele Brosolo Viviana Casarsa Luca Bulfone Laura Scandolin Cristiana Catena Leonardo A. Sechi |
| author_facet | Andrea Da Porto Gabriele Brosolo Viviana Casarsa Luca Bulfone Laura Scandolin Cristiana Catena Leonardo A. Sechi |
| author_sort | Andrea Da Porto |
| collection | DOAJ |
| description | Type 2 diabetes currently accounts for more than 90% of all diabetic patients. Lifestyle interventions and notably dietary modifications are one of the mainstays for the prevention and treatment of type 2 diabetes. In this context, the Mediterranean diet with its elevated content of phytonutrients has been demonstrated to effectively improve glucose homeostasis. Oleuropein is the most abundant polyphenolic compound contained in extra-virgin olive oil and might account for some of the anti-diabetic actions of the Mediterranean diet. With the aim to provide an overview of the possible contributions of oleuropein to glucose metabolism, we conducted a PubMed/Medline search in order to provide an update to the available evidence regarding this interesting compound. This narrative review summarizes the data that was obtained in in vitro and animal studies and the results of clinical investigations. Preclinical studies indicate that oleuropein improves glucose transport, increases insulin sensitivity, and facilitates insulin secretion by pancreatic β-cells, thereby supporting the hypothesis of the possible benefits of the control of hyperglycemia. However, on the clinical side, the available evidence is still preliminary and requires more extensive investigations. Thus, many questions remain unanswered in regards to the potential benefits of oleuropein in diabetes prevention and treatment. These questions should be addressed in appropriately designed studies in the future. |
| first_indexed | 2024-03-10T00:44:19Z |
| format | Article |
| id | doaj.art-a2530c91813a4c0d906f582dc75efe0e |
| institution | Directory Open Access Journal |
| issn | 1999-4923 |
| language | English |
| last_indexed | 2024-03-10T00:44:19Z |
| publishDate | 2021-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceutics |
| spelling | doaj.art-a2530c91813a4c0d906f582dc75efe0e2023-11-23T15:02:54ZengMDPI AGPharmaceutics1999-49232021-12-011414010.3390/pharmaceutics14010040The Pivotal Role of Oleuropein in the Anti-Diabetic Action of the Mediterranean Diet: A Concise ReviewAndrea Da Porto0Gabriele Brosolo1Viviana Casarsa2Luca Bulfone3Laura Scandolin4Cristiana Catena5Leonardo A. Sechi6Clinica Medica, Department of Medicine, University of Udine, 33100 Udine, ItalyClinica Medica, Department of Medicine, University of Udine, 33100 Udine, ItalyClinica Medica, Department of Medicine, University of Udine, 33100 Udine, ItalyClinica Medica, Department of Medicine, University of Udine, 33100 Udine, ItalyClinica Medica, Department of Medicine, University of Udine, 33100 Udine, ItalyClinica Medica, Department of Medicine, University of Udine, 33100 Udine, ItalyClinica Medica, Department of Medicine, University of Udine, 33100 Udine, ItalyType 2 diabetes currently accounts for more than 90% of all diabetic patients. Lifestyle interventions and notably dietary modifications are one of the mainstays for the prevention and treatment of type 2 diabetes. In this context, the Mediterranean diet with its elevated content of phytonutrients has been demonstrated to effectively improve glucose homeostasis. Oleuropein is the most abundant polyphenolic compound contained in extra-virgin olive oil and might account for some of the anti-diabetic actions of the Mediterranean diet. With the aim to provide an overview of the possible contributions of oleuropein to glucose metabolism, we conducted a PubMed/Medline search in order to provide an update to the available evidence regarding this interesting compound. This narrative review summarizes the data that was obtained in in vitro and animal studies and the results of clinical investigations. Preclinical studies indicate that oleuropein improves glucose transport, increases insulin sensitivity, and facilitates insulin secretion by pancreatic β-cells, thereby supporting the hypothesis of the possible benefits of the control of hyperglycemia. However, on the clinical side, the available evidence is still preliminary and requires more extensive investigations. Thus, many questions remain unanswered in regards to the potential benefits of oleuropein in diabetes prevention and treatment. These questions should be addressed in appropriately designed studies in the future.https://www.mdpi.com/1999-4923/14/1/40oleuropeinMediterranean dietdiabetesmetabolic syndrome |
| spellingShingle | Andrea Da Porto Gabriele Brosolo Viviana Casarsa Luca Bulfone Laura Scandolin Cristiana Catena Leonardo A. Sechi The Pivotal Role of Oleuropein in the Anti-Diabetic Action of the Mediterranean Diet: A Concise Review Pharmaceutics oleuropein Mediterranean diet diabetes metabolic syndrome |
| title | The Pivotal Role of Oleuropein in the Anti-Diabetic Action of the Mediterranean Diet: A Concise Review |
| title_full | The Pivotal Role of Oleuropein in the Anti-Diabetic Action of the Mediterranean Diet: A Concise Review |
| title_fullStr | The Pivotal Role of Oleuropein in the Anti-Diabetic Action of the Mediterranean Diet: A Concise Review |
| title_full_unstemmed | The Pivotal Role of Oleuropein in the Anti-Diabetic Action of the Mediterranean Diet: A Concise Review |
| title_short | The Pivotal Role of Oleuropein in the Anti-Diabetic Action of the Mediterranean Diet: A Concise Review |
| title_sort | pivotal role of oleuropein in the anti diabetic action of the mediterranean diet a concise review |
| topic | oleuropein Mediterranean diet diabetes metabolic syndrome |
| url | https://www.mdpi.com/1999-4923/14/1/40 |
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