Sequential multi-parametric MRI in assessment of the histological subtype and features in the malignant pleural mesothelioma xenografts
Objective: It is still a challenge to find a noninvasive technique to distinguish the histological subtypes of malignant pleural mesothelioma (MPM) and characterize the development of related histological features. We investigated the potential value of multiparametric MRI in the assessment of the h...
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| Format: | Article |
| Language: | English |
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Elsevier
2023-04-01
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| Series: | Heliyon |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2405844023024441 |
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| author | Zhenghua Zhang Shasha Shen Jiyao Ma Tianfu Qi Chao Gao Xiong Hu Dan Han Yilong Huang |
| author_facet | Zhenghua Zhang Shasha Shen Jiyao Ma Tianfu Qi Chao Gao Xiong Hu Dan Han Yilong Huang |
| author_sort | Zhenghua Zhang |
| collection | DOAJ |
| description | Objective: It is still a challenge to find a noninvasive technique to distinguish the histological subtypes of malignant pleural mesothelioma (MPM) and characterize the development of related histological features. We investigated the potential value of multiparametric MRI in the assessment of the histological subtype and development of histologic features in the MPM xenograft model. Methods: MPM xenograft models were developed by injecting tumour cells into the right axillary space of nude mice. The T1, T2, R2*, T2*, apparent diffusion coefficient (ADC), true diffusion coefficient (D), pseudo diffusion coefficient (D*), and perfusion fraction (f) at 14 d, 28 d, and 42 d were measured and compared between the epithelial and biphasic MPM. Correlations between multiparametric MRI parameters and histologic features, including necrotic fraction (NF) and microvessel density (MVD), were analysed. Results: This study found that T2, T2* and IVIM-DWI parameters can reflect the spatial and temporal heterogeneity of MPM. Compared to the epithelial MPM, T2 and T2* were higher and ADC, D, D*, and f were lower in the biphasic MPM (P < 0.05). MRI parameters were different in different stages of epithelial and biphasic MPM. Moderate correlations were found between ADC and tumor volume and NF in the epithelial MPM, and there was a correlation between f and tumor volume and NF and MVD in the two groups. Conclusion: MRI parameters changed with tumor progression in a xenograft model of MPM. MRI parameters may provide useful biomarkers for evaluating the histological subtype and histological features development of MPM. |
| first_indexed | 2024-04-09T15:17:25Z |
| format | Article |
| id | doaj.art-a256d4d3aa9f45429c0d4129eb99b5c6 |
| institution | Directory Open Access Journal |
| issn | 2405-8440 |
| language | English |
| last_indexed | 2024-04-09T15:17:25Z |
| publishDate | 2023-04-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Heliyon |
| spelling | doaj.art-a256d4d3aa9f45429c0d4129eb99b5c62023-04-29T14:55:52ZengElsevierHeliyon2405-84402023-04-0194e15237Sequential multi-parametric MRI in assessment of the histological subtype and features in the malignant pleural mesothelioma xenograftsZhenghua Zhang0Shasha Shen1Jiyao Ma2Tianfu Qi3Chao Gao4Xiong Hu5Dan Han6Yilong Huang7Medical Imaging Department, First Affiliated Hospital of Kunming Medical University, Kunming, 650000, ChinaMedical Imaging Department, First Affiliated Hospital of Kunming Medical University, Kunming, 650000, ChinaMedical Imaging Department, First Affiliated Hospital of Kunming Medical University, Kunming, 650000, ChinaMedical Imaging Department, First Affiliated Hospital of Kunming Medical University, Kunming, 650000, ChinaMedical Imaging Department, First Affiliated Hospital of Kunming Medical University, Kunming, 650000, ChinaPathology Department, First Affiliated Hospital of Kunming Medical University, Kunming, 650000, ChinaMedical Imaging Department, First Affiliated Hospital of Kunming Medical University, Kunming, 650000, China; Corresponding author.Medical Imaging Department, First Affiliated Hospital of Kunming Medical University, Kunming, 650000, ChinaObjective: It is still a challenge to find a noninvasive technique to distinguish the histological subtypes of malignant pleural mesothelioma (MPM) and characterize the development of related histological features. We investigated the potential value of multiparametric MRI in the assessment of the histological subtype and development of histologic features in the MPM xenograft model. Methods: MPM xenograft models were developed by injecting tumour cells into the right axillary space of nude mice. The T1, T2, R2*, T2*, apparent diffusion coefficient (ADC), true diffusion coefficient (D), pseudo diffusion coefficient (D*), and perfusion fraction (f) at 14 d, 28 d, and 42 d were measured and compared between the epithelial and biphasic MPM. Correlations between multiparametric MRI parameters and histologic features, including necrotic fraction (NF) and microvessel density (MVD), were analysed. Results: This study found that T2, T2* and IVIM-DWI parameters can reflect the spatial and temporal heterogeneity of MPM. Compared to the epithelial MPM, T2 and T2* were higher and ADC, D, D*, and f were lower in the biphasic MPM (P < 0.05). MRI parameters were different in different stages of epithelial and biphasic MPM. Moderate correlations were found between ADC and tumor volume and NF in the epithelial MPM, and there was a correlation between f and tumor volume and NF and MVD in the two groups. Conclusion: MRI parameters changed with tumor progression in a xenograft model of MPM. MRI parameters may provide useful biomarkers for evaluating the histological subtype and histological features development of MPM.http://www.sciencedirect.com/science/article/pii/S2405844023024441Multiparametric MRIMalignant pleural mesotheliomaHistological subtypeMicrovessel densityNecrosis |
| spellingShingle | Zhenghua Zhang Shasha Shen Jiyao Ma Tianfu Qi Chao Gao Xiong Hu Dan Han Yilong Huang Sequential multi-parametric MRI in assessment of the histological subtype and features in the malignant pleural mesothelioma xenografts Heliyon Multiparametric MRI Malignant pleural mesothelioma Histological subtype Microvessel density Necrosis |
| title | Sequential multi-parametric MRI in assessment of the histological subtype and features in the malignant pleural mesothelioma xenografts |
| title_full | Sequential multi-parametric MRI in assessment of the histological subtype and features in the malignant pleural mesothelioma xenografts |
| title_fullStr | Sequential multi-parametric MRI in assessment of the histological subtype and features in the malignant pleural mesothelioma xenografts |
| title_full_unstemmed | Sequential multi-parametric MRI in assessment of the histological subtype and features in the malignant pleural mesothelioma xenografts |
| title_short | Sequential multi-parametric MRI in assessment of the histological subtype and features in the malignant pleural mesothelioma xenografts |
| title_sort | sequential multi parametric mri in assessment of the histological subtype and features in the malignant pleural mesothelioma xenografts |
| topic | Multiparametric MRI Malignant pleural mesothelioma Histological subtype Microvessel density Necrosis |
| url | http://www.sciencedirect.com/science/article/pii/S2405844023024441 |
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