The synergism of cytosolic acidosis and reduced NAD+/NADH ratio is responsible for lactic acidosis-induced vascular smooth muscle cell impairment in sepsis

The synergism of cytosolic acidosis and reduced NAD+/NADH ratio is responsible for lactic acidosis-induced vascular smooth muscle cell impairment in sepsis

Abstract Background During sepsis, serve vascular dysfunctions lead to life-threatening multiple organ failure, due to vascular smooth muscle cells (VSMC) impairments, resulting in vasoplegia, hypotension and hypoperfusion. In addition, septic patients have an altered cell metabolism that leads to l...

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Bibliographic Details
Main Authors: Philipp Terpe, Stefanie Ruhs, Virginie Dubourg, Michael Bucher, Michael Gekle
Format: Article
Language:English
Published: BMC 2024-01-01
Series:Journal of Biomedical Science
Subjects:
Sepsis
Metabolism
Lactic acidosis
Acidosis
Vascular smooth muscle cells
NAD+/NADH ratio
Online Access:https://doi.org/10.1186/s12929-023-00992-6

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