The relationship between emotional disorders and heart rate variability: A Mendelian randomization study.
<h4>Objective</h4>Previous studies have shown that emotional disorders are negatively associated with heart rate variability (HRV), but the potential causal relationship between genetic susceptibility to emotional disorders and HRV remains unclear. We aimed to perform a Mendelian randomi...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2024-01-01
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| Series: | PLoS ONE |
| Online Access: | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0298998&type=printable |
| _version_ | 1827319114448764928 |
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| author | Xu Luo Rui Wang YunXiang Zhou Wen Xie |
| author_facet | Xu Luo Rui Wang YunXiang Zhou Wen Xie |
| author_sort | Xu Luo |
| collection | DOAJ |
| description | <h4>Objective</h4>Previous studies have shown that emotional disorders are negatively associated with heart rate variability (HRV), but the potential causal relationship between genetic susceptibility to emotional disorders and HRV remains unclear. We aimed to perform a Mendelian randomization (MR) study to investigate the potential association between emotional disorders and HRV.<h4>Methods</h4>The data used for this study were obtained from publicly available genome-wide association study datasets. Five models, including the inverse variance weighted model (IVW), the weighted median estimation model (WME), the weighted model-based method (WM), the simple model (SM) and the MR-Egger regression model (MER), were utilized for MR. The leave-one-out sensitivity test, MR pleiotropy residual sum and outlier test (MR-PRESSO) and Cochran's Q test were used to confirm heterogeneity and pleiotropy.<h4>Results</h4>MR analysis revealed that genetic susceptibility to broad depression was negatively correlated with HRV (pvRSA/HF) (OR = 0.380, 95% CI 0.146-0.992; p = 0.048). However, genetic susceptibility to irritability was positively correlated with HRV (pvRSA/HF, SDNN) (OR = 2.017, 95% CI 1.152-3.534, p = 0.008) (OR = 1.154, 95% CI 1.000-1.331, p = 0.044). Genetic susceptibility to anxiety was positively correlated with HRV (RMSSD) (OR = 2.106, 95% CI 1.032-4.299; p = 0.041). No significant directional pleiotropy or heterogeneity was detected. The accuracy and robustness of these findings were confirmed through a sensitivity analysis.<h4>Conclusions</h4>Our MR study provides genetic support for the causal effects of broad depression, irritable mood, and anxiety on HRV. |
| first_indexed | 2024-04-25T00:14:46Z |
| format | Article |
| id | doaj.art-a2589ecae3864a268d69efdde00952c7 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-04-25T00:14:46Z |
| publishDate | 2024-01-01 |
| publisher | Public Library of Science (PLoS) |
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| series | PLoS ONE |
| spelling | doaj.art-a2589ecae3864a268d69efdde00952c72024-03-13T05:31:30ZengPublic Library of Science (PLoS)PLoS ONE1932-62032024-01-01193e029899810.1371/journal.pone.0298998The relationship between emotional disorders and heart rate variability: A Mendelian randomization study.Xu LuoRui WangYunXiang ZhouWen Xie<h4>Objective</h4>Previous studies have shown that emotional disorders are negatively associated with heart rate variability (HRV), but the potential causal relationship between genetic susceptibility to emotional disorders and HRV remains unclear. We aimed to perform a Mendelian randomization (MR) study to investigate the potential association between emotional disorders and HRV.<h4>Methods</h4>The data used for this study were obtained from publicly available genome-wide association study datasets. Five models, including the inverse variance weighted model (IVW), the weighted median estimation model (WME), the weighted model-based method (WM), the simple model (SM) and the MR-Egger regression model (MER), were utilized for MR. The leave-one-out sensitivity test, MR pleiotropy residual sum and outlier test (MR-PRESSO) and Cochran's Q test were used to confirm heterogeneity and pleiotropy.<h4>Results</h4>MR analysis revealed that genetic susceptibility to broad depression was negatively correlated with HRV (pvRSA/HF) (OR = 0.380, 95% CI 0.146-0.992; p = 0.048). However, genetic susceptibility to irritability was positively correlated with HRV (pvRSA/HF, SDNN) (OR = 2.017, 95% CI 1.152-3.534, p = 0.008) (OR = 1.154, 95% CI 1.000-1.331, p = 0.044). Genetic susceptibility to anxiety was positively correlated with HRV (RMSSD) (OR = 2.106, 95% CI 1.032-4.299; p = 0.041). No significant directional pleiotropy or heterogeneity was detected. The accuracy and robustness of these findings were confirmed through a sensitivity analysis.<h4>Conclusions</h4>Our MR study provides genetic support for the causal effects of broad depression, irritable mood, and anxiety on HRV.https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0298998&type=printable |
| spellingShingle | Xu Luo Rui Wang YunXiang Zhou Wen Xie The relationship between emotional disorders and heart rate variability: A Mendelian randomization study. PLoS ONE |
| title | The relationship between emotional disorders and heart rate variability: A Mendelian randomization study. |
| title_full | The relationship between emotional disorders and heart rate variability: A Mendelian randomization study. |
| title_fullStr | The relationship between emotional disorders and heart rate variability: A Mendelian randomization study. |
| title_full_unstemmed | The relationship between emotional disorders and heart rate variability: A Mendelian randomization study. |
| title_short | The relationship between emotional disorders and heart rate variability: A Mendelian randomization study. |
| title_sort | relationship between emotional disorders and heart rate variability a mendelian randomization study |
| url | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0298998&type=printable |
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