BaP/BPDE suppressed endothelial cell angiogenesis to induce miscarriage by promoting MARCHF1/GPX4-mediated ferroptosis

BaP/BPDE suppressed endothelial cell angiogenesis to induce miscarriage by promoting MARCHF1/GPX4-mediated ferroptosis

Environmental benzo(a)pyrene (BaP) and its ultimate metabolite BPDE (benzo(a)pyrene-7,8-dihydrodiol-9,10-epoxide) are universal and inevitable persistent organic pollutants and endocrine disrupting chemicals. Angiogenesis in placental decidua plays a pivotal role in healthy pregnancy. Ferroptosis is...

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Bibliographic Details
Main Authors: Ying Zhang, Yang Yang, Weina Chen, Chenyang Mi, Xiaole Xu, Yanqiu Shen, Zhaodian Zheng, Zhongyan Xu, Jingsong Zhao, Shukun Wan, Xiaoqing Wang, Huidong Zhang
Format: Article
Language:English
Published: Elsevier 2023-10-01
Series:Environment International
Subjects:
Environmental exposure
BaP (Benzo(a)pyrene)
BPDE (benzo(a)pyrene-7,8-dihydrodiol-9,10-epoxide)
Ferroptosis
Angiogenesis
Miscarriage
Online Access:http://www.sciencedirect.com/science/article/pii/S016041202300510X

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http://www.sciencedirect.com/science/article/pii/S016041202300510X

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