Production of Neutrophil Extracellular Traps Contributes to the Pathogenesis of Francisella tularemia

Production of Neutrophil Extracellular Traps Contributes to the Pathogenesis of Francisella tularemia

Francisella tularensis(Ft) is a highly virulent, intracellular Gram-negative bacterial pathogen. Acute Ft infection by aerosol route causes pneumonic tularemia, characterized by nodular hemorrhagic lesions, neutrophil-predominant influx, necrotic debris, fibrin deposition, and severe alveolitis. Ft...

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Bibliographic Details
Main Authors: Sivasami Pulavendran, Maram Prasanthi, Akhilesh Ramachandran, Rezabek Grant, Timothy A. Snider, Vincent T. K. Chow, Jerry R. Malayer, Narasaraju Teluguakula
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-04-01
Series:Frontiers in Immunology
Subjects:
Francisella
neutrophil extracellular traps
myeloperoxidase
NEtosis
alveolar injury
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2020.00679/full

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