Prevention of ventilator-associated pneumonia with probiotics: an overview of systematic reviews
BackgroundProbiotics has been used as an adjuvant therapy for the prevention of ventilator-associated pneumonia (VAP). This study aimed to systematically compile, evaluate, and synthesize previous systematic reviews (SRs) and meta-analyses (MAs) on the prevention of VAP with probiotics.MethodsThe me...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2024-02-01
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| Series: | Frontiers in Microbiology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmicb.2024.1345278/full |
| _version_ | 1797311663310897152 |
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| author | Minjuan Han Ke Wang Lei Sun Wang Liu Wanhu Dong |
| author_facet | Minjuan Han Ke Wang Lei Sun Wang Liu Wanhu Dong |
| author_sort | Minjuan Han |
| collection | DOAJ |
| description | BackgroundProbiotics has been used as an adjuvant therapy for the prevention of ventilator-associated pneumonia (VAP). This study aimed to systematically compile, evaluate, and synthesize previous systematic reviews (SRs) and meta-analyses (MAs) on the prevention of VAP with probiotics.MethodsThe methodological quality, reporting quality, and evidence quality of enrolled studies were, respectively evaluated by Assessment of Multiple Systematic Reviews 2 (AMSTAR-2) tool, Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) checklists, and Grading of Recommendations, Assessment, Development, and Evaluation (GRADE) system.ResultsThirteen eligible publications were analyzed in this overview. The included studies were rated as generally low methodological quality owing to the lack of a registered protocol or a list of exclusion criteria. The inadequate quality of the reports was demonstrated by the lack of reporting on the registration protocols, the lack of reporting on the search strategy, and the lack of reporting on the additional analyses. For GRADE, there were 36.17% (17/47) outcomes graded to be of moderate quality, 42.55% (20/47) to be of low quality, and 21.28% (10/47) to be of very low quality.ConclusionProbiotics may be associated with reduced incidence of VAP. However, caution should be exercised when recommending probiotics for the prevention of VAP owing to the poor quality of the current evidence. |
| first_indexed | 2024-03-08T02:02:57Z |
| format | Article |
| id | doaj.art-a25b6946e1c84a77808a3aa7bd7353bb |
| institution | Directory Open Access Journal |
| issn | 1664-302X |
| language | English |
| last_indexed | 2024-03-08T02:02:57Z |
| publishDate | 2024-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Microbiology |
| spelling | doaj.art-a25b6946e1c84a77808a3aa7bd7353bb2024-02-14T04:49:49ZengFrontiers Media S.A.Frontiers in Microbiology1664-302X2024-02-011510.3389/fmicb.2024.13452781345278Prevention of ventilator-associated pneumonia with probiotics: an overview of systematic reviewsMinjuan Han0Ke Wang1Lei Sun2Wang Liu3Wanhu Dong4Affiliated Hospital of Shaanxi University of Chinese Medicine, Xianyang, ChinaYan'an University Xianyang Hospital, Xianyang, ChinaShaanxi University of Chinese Medicine, Xianyang, ChinaAffiliated Hospital of Shaanxi University of Chinese Medicine, Xianyang, ChinaAffiliated Hospital of Shaanxi University of Chinese Medicine, Xianyang, ChinaBackgroundProbiotics has been used as an adjuvant therapy for the prevention of ventilator-associated pneumonia (VAP). This study aimed to systematically compile, evaluate, and synthesize previous systematic reviews (SRs) and meta-analyses (MAs) on the prevention of VAP with probiotics.MethodsThe methodological quality, reporting quality, and evidence quality of enrolled studies were, respectively evaluated by Assessment of Multiple Systematic Reviews 2 (AMSTAR-2) tool, Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) checklists, and Grading of Recommendations, Assessment, Development, and Evaluation (GRADE) system.ResultsThirteen eligible publications were analyzed in this overview. The included studies were rated as generally low methodological quality owing to the lack of a registered protocol or a list of exclusion criteria. The inadequate quality of the reports was demonstrated by the lack of reporting on the registration protocols, the lack of reporting on the search strategy, and the lack of reporting on the additional analyses. For GRADE, there were 36.17% (17/47) outcomes graded to be of moderate quality, 42.55% (20/47) to be of low quality, and 21.28% (10/47) to be of very low quality.ConclusionProbiotics may be associated with reduced incidence of VAP. However, caution should be exercised when recommending probiotics for the prevention of VAP owing to the poor quality of the current evidence.https://www.frontiersin.org/articles/10.3389/fmicb.2024.1345278/fulltreatmentprobioticsventilator-associated pneumoniaevidenceadjunctive |
| spellingShingle | Minjuan Han Ke Wang Lei Sun Wang Liu Wanhu Dong Prevention of ventilator-associated pneumonia with probiotics: an overview of systematic reviews Frontiers in Microbiology treatment probiotics ventilator-associated pneumonia evidence adjunctive |
| title | Prevention of ventilator-associated pneumonia with probiotics: an overview of systematic reviews |
| title_full | Prevention of ventilator-associated pneumonia with probiotics: an overview of systematic reviews |
| title_fullStr | Prevention of ventilator-associated pneumonia with probiotics: an overview of systematic reviews |
| title_full_unstemmed | Prevention of ventilator-associated pneumonia with probiotics: an overview of systematic reviews |
| title_short | Prevention of ventilator-associated pneumonia with probiotics: an overview of systematic reviews |
| title_sort | prevention of ventilator associated pneumonia with probiotics an overview of systematic reviews |
| topic | treatment probiotics ventilator-associated pneumonia evidence adjunctive |
| url | https://www.frontiersin.org/articles/10.3389/fmicb.2024.1345278/full |
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