Zebrafish in Inflammasome Research
Inflammasomes are cytosolic multiprotein complexes that regulate inflammatory responses to danger stimuli and infection, and their dysregulation is associated with an increasing number of autoinflammatory diseases. In recent years, zebrafish models of human pathologies to study inflammasome function...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2019-08-01
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| Series: | Cells |
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| Online Access: | https://www.mdpi.com/2073-4409/8/8/901 |
| _version_ | 1797756991437799424 |
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| author | Gabriel Forn-Cuní Annemarie H. Meijer Monica Varela |
| author_facet | Gabriel Forn-Cuní Annemarie H. Meijer Monica Varela |
| author_sort | Gabriel Forn-Cuní |
| collection | DOAJ |
| description | Inflammasomes are cytosolic multiprotein complexes that regulate inflammatory responses to danger stimuli and infection, and their dysregulation is associated with an increasing number of autoinflammatory diseases. In recent years, zebrafish models of human pathologies to study inflammasome function in vivo have started to emerge. Here, we discuss inflammasome research in zebrafish in light of current knowledge about mammalian inflammasomes. We summarize the evolutionary conservation of inflammasome components between zebrafish and mammals, highlighting the similarities and possible divergence in functions of these components. We present new insights into the evolution of the caspase-1 family in the teleost lineage, and how its evolutionary origin may help contextualize its functions. We also review existing infectious and non-infectious models in zebrafish in which inflammasomes have been directly implicated. Finally, we discuss the advantages of zebrafish larvae for intravital imaging of inflammasome activation and summarize available tools that will help to advance inflammasome research. |
| first_indexed | 2024-03-12T18:09:33Z |
| format | Article |
| id | doaj.art-a25c290afb734e5fb675d1684b8d2851 |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-12T18:09:33Z |
| publishDate | 2019-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-a25c290afb734e5fb675d1684b8d28512023-08-02T09:17:32ZengMDPI AGCells2073-44092019-08-018890110.3390/cells8080901cells8080901Zebrafish in Inflammasome ResearchGabriel Forn-Cuní0Annemarie H. Meijer1Monica Varela2Institute of Biology Leiden, Leiden University, Einsteinweg 55, 2333 CC Leiden, The NetherlandsInstitute of Biology Leiden, Leiden University, Einsteinweg 55, 2333 CC Leiden, The NetherlandsInstitute of Biology Leiden, Leiden University, Einsteinweg 55, 2333 CC Leiden, The NetherlandsInflammasomes are cytosolic multiprotein complexes that regulate inflammatory responses to danger stimuli and infection, and their dysregulation is associated with an increasing number of autoinflammatory diseases. In recent years, zebrafish models of human pathologies to study inflammasome function in vivo have started to emerge. Here, we discuss inflammasome research in zebrafish in light of current knowledge about mammalian inflammasomes. We summarize the evolutionary conservation of inflammasome components between zebrafish and mammals, highlighting the similarities and possible divergence in functions of these components. We present new insights into the evolution of the caspase-1 family in the teleost lineage, and how its evolutionary origin may help contextualize its functions. We also review existing infectious and non-infectious models in zebrafish in which inflammasomes have been directly implicated. Finally, we discuss the advantages of zebrafish larvae for intravital imaging of inflammasome activation and summarize available tools that will help to advance inflammasome research.https://www.mdpi.com/2073-4409/8/8/901inflammasomezebrafishinflammatory caspasesgasderminevolutionary conservationpyroptosisintravital imaginganimal models |
| spellingShingle | Gabriel Forn-Cuní Annemarie H. Meijer Monica Varela Zebrafish in Inflammasome Research Cells inflammasome zebrafish inflammatory caspases gasdermin evolutionary conservation pyroptosis intravital imaging animal models |
| title | Zebrafish in Inflammasome Research |
| title_full | Zebrafish in Inflammasome Research |
| title_fullStr | Zebrafish in Inflammasome Research |
| title_full_unstemmed | Zebrafish in Inflammasome Research |
| title_short | Zebrafish in Inflammasome Research |
| title_sort | zebrafish in inflammasome research |
| topic | inflammasome zebrafish inflammatory caspases gasdermin evolutionary conservation pyroptosis intravital imaging animal models |
| url | https://www.mdpi.com/2073-4409/8/8/901 |
| work_keys_str_mv | AT gabrielforncuni zebrafishininflammasomeresearch AT annemariehmeijer zebrafishininflammasomeresearch AT monicavarela zebrafishininflammasomeresearch |