Delineating Anaplasma phagocytophilum Ecotypes in Coexisting, Discrete Enzootic Cycles
The emerging tick-borne pathogen Anaplasma phagocytophilum is under increasing scrutiny for the existence of subpopulations that are adapted to different natural cycles. Here, we characterized the diversity of A. phagocytophilum genotypes circulating in a natural system that includes multiple hosts...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Centers for Disease Control and Prevention
2009-12-01
|
| Series: | Emerging Infectious Diseases |
| Subjects: | |
| Online Access: | https://wwwnc.cdc.gov/eid/article/15/12/09-0178_article |
| _version_ | 1811280309954543616 |
|---|---|
| author | Kevin J. Bown Xavier Lambin Nicholas H. Ogden Michael Begon Gill Telford Zerai Woldehiwet Richard J. Birtles |
| author_facet | Kevin J. Bown Xavier Lambin Nicholas H. Ogden Michael Begon Gill Telford Zerai Woldehiwet Richard J. Birtles |
| author_sort | Kevin J. Bown |
| collection | DOAJ |
| description | The emerging tick-borne pathogen Anaplasma phagocytophilum is under increasing scrutiny for the existence of subpopulations that are adapted to different natural cycles. Here, we characterized the diversity of A. phagocytophilum genotypes circulating in a natural system that includes multiple hosts and at least 2 tick species, Ixodes ricinus and the small mammal specialist I. trianguliceps. We encountered numerous genotypes, but only 1 in rodents, with the remainder limited to deer and host-seeking I. ricinus ticks. The absence of the rodent-associated genotype from host-seeking I. ricinus ticks was notable because we demonstrated that rodents fed a large proportion of the I. ricinus larval population and that these larvae were abundant when infections caused by the rodent-associated genotype were prevalent. These observations are consistent with the conclusion that genotypically distinct subpopulations of A. phagocytophilum are restricted to coexisting but separate enzootic cycles and suggest that this restriction may result from specific vector compatibility. |
| first_indexed | 2024-04-13T01:11:21Z |
| format | Article |
| id | doaj.art-a25cb784406642ad975b1db664d35dc7 |
| institution | Directory Open Access Journal |
| issn | 1080-6040 1080-6059 |
| language | English |
| last_indexed | 2024-04-13T01:11:21Z |
| publishDate | 2009-12-01 |
| publisher | Centers for Disease Control and Prevention |
| record_format | Article |
| series | Emerging Infectious Diseases |
| spelling | doaj.art-a25cb784406642ad975b1db664d35dc72022-12-22T03:09:08ZengCenters for Disease Control and PreventionEmerging Infectious Diseases1080-60401080-60592009-12-0115121948195410.3201/eid1512.090178Delineating Anaplasma phagocytophilum Ecotypes in Coexisting, Discrete Enzootic CyclesKevin J. BownXavier LambinNicholas H. OgdenMichael BegonGill TelfordZerai WoldehiwetRichard J. BirtlesThe emerging tick-borne pathogen Anaplasma phagocytophilum is under increasing scrutiny for the existence of subpopulations that are adapted to different natural cycles. Here, we characterized the diversity of A. phagocytophilum genotypes circulating in a natural system that includes multiple hosts and at least 2 tick species, Ixodes ricinus and the small mammal specialist I. trianguliceps. We encountered numerous genotypes, but only 1 in rodents, with the remainder limited to deer and host-seeking I. ricinus ticks. The absence of the rodent-associated genotype from host-seeking I. ricinus ticks was notable because we demonstrated that rodents fed a large proportion of the I. ricinus larval population and that these larvae were abundant when infections caused by the rodent-associated genotype were prevalent. These observations are consistent with the conclusion that genotypically distinct subpopulations of A. phagocytophilum are restricted to coexisting but separate enzootic cycles and suggest that this restriction may result from specific vector compatibility.https://wwwnc.cdc.gov/eid/article/15/12/09-0178_articleBacteriaanaplasmavector-borne infectionsticksarthropod vectorsinfectious disease reservoirs |
| spellingShingle | Kevin J. Bown Xavier Lambin Nicholas H. Ogden Michael Begon Gill Telford Zerai Woldehiwet Richard J. Birtles Delineating Anaplasma phagocytophilum Ecotypes in Coexisting, Discrete Enzootic Cycles Emerging Infectious Diseases Bacteria anaplasma vector-borne infections ticks arthropod vectors infectious disease reservoirs |
| title | Delineating Anaplasma phagocytophilum Ecotypes in Coexisting, Discrete Enzootic Cycles |
| title_full | Delineating Anaplasma phagocytophilum Ecotypes in Coexisting, Discrete Enzootic Cycles |
| title_fullStr | Delineating Anaplasma phagocytophilum Ecotypes in Coexisting, Discrete Enzootic Cycles |
| title_full_unstemmed | Delineating Anaplasma phagocytophilum Ecotypes in Coexisting, Discrete Enzootic Cycles |
| title_short | Delineating Anaplasma phagocytophilum Ecotypes in Coexisting, Discrete Enzootic Cycles |
| title_sort | delineating anaplasma phagocytophilum ecotypes in coexisting discrete enzootic cycles |
| topic | Bacteria anaplasma vector-borne infections ticks arthropod vectors infectious disease reservoirs |
| url | https://wwwnc.cdc.gov/eid/article/15/12/09-0178_article |
| work_keys_str_mv | AT kevinjbown delineatinganaplasmaphagocytophilumecotypesincoexistingdiscreteenzooticcycles AT xavierlambin delineatinganaplasmaphagocytophilumecotypesincoexistingdiscreteenzooticcycles AT nicholashogden delineatinganaplasmaphagocytophilumecotypesincoexistingdiscreteenzooticcycles AT michaelbegon delineatinganaplasmaphagocytophilumecotypesincoexistingdiscreteenzooticcycles AT gilltelford delineatinganaplasmaphagocytophilumecotypesincoexistingdiscreteenzooticcycles AT zeraiwoldehiwet delineatinganaplasmaphagocytophilumecotypesincoexistingdiscreteenzooticcycles AT richardjbirtles delineatinganaplasmaphagocytophilumecotypesincoexistingdiscreteenzooticcycles |