Definition of two agonist types at the mammalian cold-activated channel TRPM8

Definition of two agonist types at the mammalian cold-activated channel TRPM8

Various TRP channels act as polymodal sensors of thermal and chemical stimuli, but the mechanisms whereby chemical ligands impact on TRP channel gating are poorly understood. Here we show that AITC (allyl isothiocyanate; mustard oil) and menthol represent two distinct types of ligands at the mammali...

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Bibliographic Details
Main Authors: Annelies Janssens, Maarten Gees, Balazs Istvan Toth, Debapriya Ghosh, Marie Mulier, Rudi Vennekens, Joris Vriens, Karel Talavera, Thomas Voets
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2016-07-01
Series:eLife
Subjects:
ion channels
TRP channels
ligand-gated ion channels
Online Access:https://elifesciences.org/articles/17240

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