Evolutionarily conserved long-chain Acyl-CoA synthetases regulate membrane composition and fluidity

Evolutionarily conserved long-chain Acyl-CoA synthetases regulate membrane composition and fluidity

The human AdipoR1 and AdipoR2 proteins, as well as their C. elegans homolog PAQR-2, protect against cell membrane rigidification by exogenous saturated fatty acids by regulating phospholipid composition. Here, we show that mutations in the C. elegans gene acs-13 help to suppress the phenotypes of pa...

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Bibliographic Details
Main Authors: Mario Ruiz, Rakesh Bodhicharla, Marcus Ståhlman, Emma Svensk, Kiran Busayavalasa, Henrik Palmgren, Hanna Ruhanen, Jan Boren, Marc Pilon
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2019-11-01
Series:eLife
Subjects:
phospholipids
cell membrane
acyl-coA synthetase
adiponectin receptor
forward genetics
lipidomics
Online Access:https://elifesciences.org/articles/47733

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