The Efficacy of Cholesterol-Based Carriers in Drug Delivery
Several researchers have reported the use of cholesterol-based carriers in drug delivery. The presence of cholesterol in cell membranes and its wide distribution in the body has led to it being used in preparing carriers for the delivery of a variety of therapeutic agents such as anticancer, antimal...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-09-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/25/18/4330 |
| _version_ | 1797553050478444544 |
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| author | Ngonidzashe Ruwizhi Blessing Atim Aderibigbe |
| author_facet | Ngonidzashe Ruwizhi Blessing Atim Aderibigbe |
| author_sort | Ngonidzashe Ruwizhi |
| collection | DOAJ |
| description | Several researchers have reported the use of cholesterol-based carriers in drug delivery. The presence of cholesterol in cell membranes and its wide distribution in the body has led to it being used in preparing carriers for the delivery of a variety of therapeutic agents such as anticancer, antimalarials and antivirals. These cholesterol-based carriers were designed as micelles, nanoparticles, copolymers, liposomes, etc. and their routes of administration include oral, intravenous and transdermal. The biocompatibility, good bioavailability and biological activity of cholesterol-based carriers make them potent prodrugs. Several in vitro and in vivo studies revealed cholesterol-based carriers potentials in delivering bioactive agents. In this manuscript, a critical review of the efficacy of cholesterol-based carriers is reported. |
| first_indexed | 2024-03-10T16:09:53Z |
| format | Article |
| id | doaj.art-a25df9efa02440df86600fcb82a3660d |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-10T16:09:53Z |
| publishDate | 2020-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-a25df9efa02440df86600fcb82a3660d2023-11-20T14:34:49ZengMDPI AGMolecules1420-30492020-09-012518433010.3390/molecules25184330The Efficacy of Cholesterol-Based Carriers in Drug DeliveryNgonidzashe Ruwizhi0Blessing Atim Aderibigbe1Department of Chemistry, University of Fort Hare, Alice Campus, Eastern Cape 5700, South AfricaDepartment of Chemistry, University of Fort Hare, Alice Campus, Eastern Cape 5700, South AfricaSeveral researchers have reported the use of cholesterol-based carriers in drug delivery. The presence of cholesterol in cell membranes and its wide distribution in the body has led to it being used in preparing carriers for the delivery of a variety of therapeutic agents such as anticancer, antimalarials and antivirals. These cholesterol-based carriers were designed as micelles, nanoparticles, copolymers, liposomes, etc. and their routes of administration include oral, intravenous and transdermal. The biocompatibility, good bioavailability and biological activity of cholesterol-based carriers make them potent prodrugs. Several in vitro and in vivo studies revealed cholesterol-based carriers potentials in delivering bioactive agents. In this manuscript, a critical review of the efficacy of cholesterol-based carriers is reported.https://www.mdpi.com/1420-3049/25/18/4330cholesterolanticancerantibacterialantiviralwound dressingdrug delivery system |
| spellingShingle | Ngonidzashe Ruwizhi Blessing Atim Aderibigbe The Efficacy of Cholesterol-Based Carriers in Drug Delivery Molecules cholesterol anticancer antibacterial antiviral wound dressing drug delivery system |
| title | The Efficacy of Cholesterol-Based Carriers in Drug Delivery |
| title_full | The Efficacy of Cholesterol-Based Carriers in Drug Delivery |
| title_fullStr | The Efficacy of Cholesterol-Based Carriers in Drug Delivery |
| title_full_unstemmed | The Efficacy of Cholesterol-Based Carriers in Drug Delivery |
| title_short | The Efficacy of Cholesterol-Based Carriers in Drug Delivery |
| title_sort | efficacy of cholesterol based carriers in drug delivery |
| topic | cholesterol anticancer antibacterial antiviral wound dressing drug delivery system |
| url | https://www.mdpi.com/1420-3049/25/18/4330 |
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