High Mitochondrial DNA Copy Number and Bioenergetic Function Are Associated with Tumor Invasion of Esophageal Squamous Cell Carcinoma Cell Lines

High Mitochondrial DNA Copy Number and Bioenergetic Function Are Associated with Tumor Invasion of Esophageal Squamous Cell Carcinoma Cell Lines

We previously reported a gradual increase of relative mitochondrial DNA (mtDNA) copy number during the progression of esophageal squamous cell carcinoma (ESCC). Because mitochondria are the intracellular organelles responsible for ATP production, we investigated the associations among mtDNA copy num...

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Bibliographic Details
Main Authors: Liang-Shun Wang, Yann-Jang Chen, Yau-Huei Wei, Yao-An Shen, Shu-Yu Lee, Hui-Ting Lee, Chen-Sung Lin
Format: Article
Language:English
Published: MDPI AG 2012-09-01
Series:International Journal of Molecular Sciences
Subjects:
bioenergetic function
esophageal squamous cell carcinoma (ESCC)
mitochondrial DNA (mtDNA)
invasion
epithelial mesenchymal transition (EMT)
Online Access:http://www.mdpi.com/1422-0067/13/9/11228

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