The Antidepressant-like Activity, Effects on Recognition Memory Deficits, Bioavailability, and Safety after Chronic Administration of New Dual-Acting Small Compounds Targeting Neuropsychiatric Symptoms in Dementia

The Antidepressant-like Activity, Effects on Recognition Memory Deficits, Bioavailability, and Safety after Chronic Administration of New Dual-Acting Small Compounds Targeting Neuropsychiatric Symptoms in Dementia

This study aimed to extend the body of preclinical research on prototype dual-acting compounds combining the pharmacophores relevant for inhibiting cyclic nucleotide phosphodiesterase 10 (PDE10A) and serotonin 5-HT<sub>1A</sub>/5-HT<sub>7</sub> receptor (5-HT<sub>1A<...

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Bibliographic Details
Main Authors: Magdalena Jastrzębska-Więsek, Magdalena Kotańska, Aleksandra Grzeszczak, Anna Jaromin, Maria Walczak, Anna Partyka, Joanna Gdula-Argasińska, Magdalena Smolik, Agnieszka Zagórska
Format: Article
Language:English
Published: MDPI AG 2022-09-01
Series:International Journal of Molecular Sciences
Subjects:
drug-like compounds
safety pharmacology
cytotoxicity
dementia
multitarget compounds
Online Access:https://www.mdpi.com/1422-0067/23/19/11452

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https://www.mdpi.com/1422-0067/23/19/11452

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