Risk of Vertebral Fracture in Patients Diagnosed with a Depressive Disorder: A Nationwide Population-Based Cohort Study
OBJECTIVE: Previous studies have reported that depression may play a crucial role in the occurrence of vertebral fractures. However, a clear correlation between depressive disorders and osteoporotic fractures has not been established. We explored the association between depressive disorders and subs...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier España
|
| Series: | Clinics |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1807-59322017000100044&lng=en&tlng=en |
| _version_ | 1818237264755425280 |
|---|---|
| author | Shyh-Chyang Lee Li-Yu Hu Min-Wei Huang Cheng-Che Shen Wei-Lun Huang Ti Lu Chiao-Lin Hsu Chih-Chuan Pan |
| author_facet | Shyh-Chyang Lee Li-Yu Hu Min-Wei Huang Cheng-Che Shen Wei-Lun Huang Ti Lu Chiao-Lin Hsu Chih-Chuan Pan |
| author_sort | Shyh-Chyang Lee |
| collection | DOAJ |
| description | OBJECTIVE: Previous studies have reported that depression may play a crucial role in the occurrence of vertebral fractures. However, a clear correlation between depressive disorders and osteoporotic fractures has not been established. We explored the association between depressive disorders and subsequent new-onset vertebral fractures. Additionally, we aimed to identify the potential risk factors for vertebral fracture in patients with a depressive disorder. METHODS: We studied patients listed in the Taiwan National Health Insurance Research Database who were diagnosed with a depressive disorder by a psychiatrist. The comparison cohort consisted of age- and sex-matched patients without a depressive disorder. The incidence rate and hazard ratios of subsequent vertebral fracture were evaluated. We used Cox regression analysis to evaluate the risk of vertebral fracture among patients with a depressive disorder. RESULTS: The total number of patients with and without a depressive disorder was 44,812. The incidence risk ratio (IRR) between these 2 cohorts indicated that depressive disorder patients had a higher risk of developing a subsequent vertebral fracture (IRR=1.41, 95% confidence interval [CI]=1.26-1.57, p<0.001). In the multivariate analysis, the depressive disorder cohort showed a higher risk of vertebral fracture than the comparison cohort (adjusted hazard ratio=1.24, 95% CI=1.11-1.38, p<0.001). Being older than 50 years, having a lower monthly income, and having hypertension, diabetes mellitus, cerebrovascular disease, chronic obstructive pulmonary disease, autoimmune disease, or osteoporosis were considered predictive factors for vertebral fracture in patients with depressive disorders. CONCLUSIONS: Depressive disorders may increase the risk of a subsequent new-onset vertebral fracture. |
| first_indexed | 2024-12-12T12:23:00Z |
| format | Article |
| id | doaj.art-a2626ce6310e40b99b9463a82316927a |
| institution | Directory Open Access Journal |
| issn | 1980-5322 |
| language | English |
| last_indexed | 2024-12-12T12:23:00Z |
| publisher | Elsevier España |
| record_format | Article |
| series | Clinics |
| spelling | doaj.art-a2626ce6310e40b99b9463a82316927a2022-12-22T00:24:37ZengElsevier EspañaClinics1980-5322721445010.6061/clinics/2017(01)08S1807-59322017000100044Risk of Vertebral Fracture in Patients Diagnosed with a Depressive Disorder: A Nationwide Population-Based Cohort StudyShyh-Chyang LeeLi-Yu HuMin-Wei HuangCheng-Che ShenWei-Lun HuangTi LuChiao-Lin HsuChih-Chuan PanOBJECTIVE: Previous studies have reported that depression may play a crucial role in the occurrence of vertebral fractures. However, a clear correlation between depressive disorders and osteoporotic fractures has not been established. We explored the association between depressive disorders and subsequent new-onset vertebral fractures. Additionally, we aimed to identify the potential risk factors for vertebral fracture in patients with a depressive disorder. METHODS: We studied patients listed in the Taiwan National Health Insurance Research Database who were diagnosed with a depressive disorder by a psychiatrist. The comparison cohort consisted of age- and sex-matched patients without a depressive disorder. The incidence rate and hazard ratios of subsequent vertebral fracture were evaluated. We used Cox regression analysis to evaluate the risk of vertebral fracture among patients with a depressive disorder. RESULTS: The total number of patients with and without a depressive disorder was 44,812. The incidence risk ratio (IRR) between these 2 cohorts indicated that depressive disorder patients had a higher risk of developing a subsequent vertebral fracture (IRR=1.41, 95% confidence interval [CI]=1.26-1.57, p<0.001). In the multivariate analysis, the depressive disorder cohort showed a higher risk of vertebral fracture than the comparison cohort (adjusted hazard ratio=1.24, 95% CI=1.11-1.38, p<0.001). Being older than 50 years, having a lower monthly income, and having hypertension, diabetes mellitus, cerebrovascular disease, chronic obstructive pulmonary disease, autoimmune disease, or osteoporosis were considered predictive factors for vertebral fracture in patients with depressive disorders. CONCLUSIONS: Depressive disorders may increase the risk of a subsequent new-onset vertebral fracture.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1807-59322017000100044&lng=en&tlng=enDepressive DisorderOsteoporotic FractureVertebral FractureRisk Factor |
| spellingShingle | Shyh-Chyang Lee Li-Yu Hu Min-Wei Huang Cheng-Che Shen Wei-Lun Huang Ti Lu Chiao-Lin Hsu Chih-Chuan Pan Risk of Vertebral Fracture in Patients Diagnosed with a Depressive Disorder: A Nationwide Population-Based Cohort Study Clinics Depressive Disorder Osteoporotic Fracture Vertebral Fracture Risk Factor |
| title | Risk of Vertebral Fracture in Patients Diagnosed with a Depressive Disorder: A Nationwide Population-Based Cohort Study |
| title_full | Risk of Vertebral Fracture in Patients Diagnosed with a Depressive Disorder: A Nationwide Population-Based Cohort Study |
| title_fullStr | Risk of Vertebral Fracture in Patients Diagnosed with a Depressive Disorder: A Nationwide Population-Based Cohort Study |
| title_full_unstemmed | Risk of Vertebral Fracture in Patients Diagnosed with a Depressive Disorder: A Nationwide Population-Based Cohort Study |
| title_short | Risk of Vertebral Fracture in Patients Diagnosed with a Depressive Disorder: A Nationwide Population-Based Cohort Study |
| title_sort | risk of vertebral fracture in patients diagnosed with a depressive disorder a nationwide population based cohort study |
| topic | Depressive Disorder Osteoporotic Fracture Vertebral Fracture Risk Factor |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1807-59322017000100044&lng=en&tlng=en |
| work_keys_str_mv | AT shyhchyanglee riskofvertebralfractureinpatientsdiagnosedwithadepressivedisorderanationwidepopulationbasedcohortstudy AT liyuhu riskofvertebralfractureinpatientsdiagnosedwithadepressivedisorderanationwidepopulationbasedcohortstudy AT minweihuang riskofvertebralfractureinpatientsdiagnosedwithadepressivedisorderanationwidepopulationbasedcohortstudy AT chengcheshen riskofvertebralfractureinpatientsdiagnosedwithadepressivedisorderanationwidepopulationbasedcohortstudy AT weilunhuang riskofvertebralfractureinpatientsdiagnosedwithadepressivedisorderanationwidepopulationbasedcohortstudy AT tilu riskofvertebralfractureinpatientsdiagnosedwithadepressivedisorderanationwidepopulationbasedcohortstudy AT chiaolinhsu riskofvertebralfractureinpatientsdiagnosedwithadepressivedisorderanationwidepopulationbasedcohortstudy AT chihchuanpan riskofvertebralfractureinpatientsdiagnosedwithadepressivedisorderanationwidepopulationbasedcohortstudy |