Relationship between serum testosterone concentration and microvascular endothelial function in Japanese men
Background: Both endothelial dysfunction and low circulating androgen levels predict cardiovascular disease in men. Endothelial function evaluation is commonly performed by measuring flow-mediated vasodilatation of the brachial artery. However, studies have suggested that compared with evaluation...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
MRE Press
2021-04-01
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| Series: | Journal of Men's Health |
| Subjects: | |
| Online Access: | https://oss.jomh.org/jomh/article/20210409-232/pdf/64-69%20JOMH2020121401.pdf |
| _version_ | 1827359278995865600 |
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| author | Hiroshi Kumagai Asako Zempo-Miyaki Toru Yoshikawa Kanae Myoenzono Koichiro Tanahashi Nobuhiko Akazawa Seiji Maeda |
| author_facet | Hiroshi Kumagai Asako Zempo-Miyaki Toru Yoshikawa Kanae Myoenzono Koichiro Tanahashi Nobuhiko Akazawa Seiji Maeda |
| author_sort | Hiroshi Kumagai |
| collection | DOAJ |
| description | Background: Both endothelial dysfunction and low circulating androgen
levels predict cardiovascular disease in men. Endothelial function evaluation is
commonly performed by measuring flow-mediated vasodilatation of the brachial
artery. However, studies have suggested that compared with evaluation of large
arteries, microvascular function evaluation of peripheral arteries is a better
predictor of increased cardiovascular disease risks. Although circulating levels
of androgens, such as testosterone and dehydroepiandrosterone sulfate (DHEA-S),
positively correlate with cardiovascular function, the association between
circulating androgen levels and microvascular function is unknown. In this study,
we investigated whether serum androgen levels correlate with microvascular
endothelial function in men. Methods: The study included 105 Japanese men (age 59 ± 1 years)
in whom we measured serum testosterone and DHEA-S levels. The reactive hyperemia
index (RHI) determined by the Endo-PAT system (finger plethysmography) was used
to evaluate microvascular endothelial function. Results: Serum testosterone levels were significantly correlated with
the RHI (r = 0.32, P < 0.01). The association between serum
testosterone levels and the RHI remained significant even after adjustment for
confounders, including age and body mass index (β = 0.31,
P < 0.01). Notably, serum DHEA-S levels were not associated with the
RHI (r = 0.01, n.s.). Conclusion: This study showed that serum testosterone levels were
positively correlated with microvascular endothelial function in men. These
results suggest that endogenous testosterone level is one of the determinants of
microvascular endothelial function and may become a biomarker reflecting
lifestyle modifications-induced improvement in cardiovascular function in men. |
| first_indexed | 2024-03-08T06:26:31Z |
| format | Article |
| id | doaj.art-a262a8039bdf475cb79898756af6550f |
| institution | Directory Open Access Journal |
| issn | 1875-6859 |
| language | English |
| last_indexed | 2024-03-08T06:26:31Z |
| publishDate | 2021-04-01 |
| publisher | MRE Press |
| record_format | Article |
| series | Journal of Men's Health |
| spelling | doaj.art-a262a8039bdf475cb79898756af6550f2024-02-03T14:45:07ZengMRE PressJournal of Men's Health1875-68592021-04-01172646910.31083/jomh.2021.013S1875-6867(21)00309-2Relationship between serum testosterone concentration and microvascular endothelial function in Japanese menHiroshi Kumagai0Asako Zempo-Miyaki1Toru Yoshikawa2Kanae Myoenzono3Koichiro Tanahashi4Nobuhiko Akazawa5Seiji Maeda6Faculty of Health and Sport Sciences, University of Tsukuba, Tsukuba, 305-8574 Ibaraki, JapanFaculty of Health & Sport Sciences, Ryutsu Keizai University, Ryugasaki, 301-8555 Ibaraki, JapanFaculty of Health & Sport Sciences, Ryutsu Keizai University, Ryugasaki, 301-8555 Ibaraki, JapanGraduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, 305-8574 Ibaraki, JapanFaculty of Health and Sport Sciences, University of Tsukuba, Tsukuba, 305-8574 Ibaraki, JapanFaculty of Health and Sport Sciences, University of Tsukuba, Tsukuba, 305-8574 Ibaraki, JapanFaculty of Health and Sport Sciences, University of Tsukuba, Tsukuba, 305-8574 Ibaraki, JapanBackground: Both endothelial dysfunction and low circulating androgen levels predict cardiovascular disease in men. Endothelial function evaluation is commonly performed by measuring flow-mediated vasodilatation of the brachial artery. However, studies have suggested that compared with evaluation of large arteries, microvascular function evaluation of peripheral arteries is a better predictor of increased cardiovascular disease risks. Although circulating levels of androgens, such as testosterone and dehydroepiandrosterone sulfate (DHEA-S), positively correlate with cardiovascular function, the association between circulating androgen levels and microvascular function is unknown. In this study, we investigated whether serum androgen levels correlate with microvascular endothelial function in men. Methods: The study included 105 Japanese men (age 59 ± 1 years) in whom we measured serum testosterone and DHEA-S levels. The reactive hyperemia index (RHI) determined by the Endo-PAT system (finger plethysmography) was used to evaluate microvascular endothelial function. Results: Serum testosterone levels were significantly correlated with the RHI (r = 0.32, P < 0.01). The association between serum testosterone levels and the RHI remained significant even after adjustment for confounders, including age and body mass index (β = 0.31, P < 0.01). Notably, serum DHEA-S levels were not associated with the RHI (r = 0.01, n.s.). Conclusion: This study showed that serum testosterone levels were positively correlated with microvascular endothelial function in men. These results suggest that endogenous testosterone level is one of the determinants of microvascular endothelial function and may become a biomarker reflecting lifestyle modifications-induced improvement in cardiovascular function in men.https://oss.jomh.org/jomh/article/20210409-232/pdf/64-69%20JOMH2020121401.pdftestosteronemicrovascular endothelial functiondehydroepiandrosteronearterial stiffnessendopat systemfinger plethysmography |
| spellingShingle | Hiroshi Kumagai Asako Zempo-Miyaki Toru Yoshikawa Kanae Myoenzono Koichiro Tanahashi Nobuhiko Akazawa Seiji Maeda Relationship between serum testosterone concentration and microvascular endothelial function in Japanese men Journal of Men's Health testosterone microvascular endothelial function dehydroepiandrosterone arterial stiffness endopat system finger plethysmography |
| title | Relationship between serum testosterone concentration and microvascular endothelial function in Japanese men |
| title_full | Relationship between serum testosterone concentration and microvascular endothelial function in Japanese men |
| title_fullStr | Relationship between serum testosterone concentration and microvascular endothelial function in Japanese men |
| title_full_unstemmed | Relationship between serum testosterone concentration and microvascular endothelial function in Japanese men |
| title_short | Relationship between serum testosterone concentration and microvascular endothelial function in Japanese men |
| title_sort | relationship between serum testosterone concentration and microvascular endothelial function in japanese men |
| topic | testosterone microvascular endothelial function dehydroepiandrosterone arterial stiffness endopat system finger plethysmography |
| url | https://oss.jomh.org/jomh/article/20210409-232/pdf/64-69%20JOMH2020121401.pdf |
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