Analysis of serum bone turnover markers in female cynomolgus monkeys of different ages
ObjectiveThe purpose of this study was to examine bone turnover markers, estradiol, parathyroid hormone, and 25 hydroxyvitamin D, in cynomolgus monkeys at different ages to improve our understanding of the changes in bone turnover markers throughout the life cycle of cynomolgus monkeys and to provid...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-10-01
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| Series: | Frontiers in Endocrinology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2022.984523/full |
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| author | Ying Li Qijun Cai Chenchen Dong Lu Hou Yingxin Li Bin Guo Chunyuan Zeng Yong Cheng Jingjie Shang Xueying Ling Jian Gong Hao Xu |
| author_facet | Ying Li Qijun Cai Chenchen Dong Lu Hou Yingxin Li Bin Guo Chunyuan Zeng Yong Cheng Jingjie Shang Xueying Ling Jian Gong Hao Xu |
| author_sort | Ying Li |
| collection | DOAJ |
| description | ObjectiveThe purpose of this study was to examine bone turnover markers, estradiol, parathyroid hormone, and 25 hydroxyvitamin D, in cynomolgus monkeys at different ages to improve our understanding of the changes in bone turnover markers throughout the life cycle of cynomolgus monkeys and to provide a basis for the establishment of a non-human primate model of osteoporosis.MethodsTotal Body Bone Mineral Density and Total Body Bone Mineral Content were measured using Dual-Energy X-Ray Absorptiometry in cynomolgus monkeys at different ages. Serum bone turnover marker' levels were measured using enzyme immunoassays at each age group, and the relationship between bone turnover markers and age was assessed by Spearman rank correlation analysis to investigate the relationship between bone turnover markers and age in female cynomolgus monkeys.ResultsTotal Body Bone Mineral Density in female cynomolgus monkeys peaked at 10 years of age and then formed a plateau that was maintained until old age. Procollagen I Aminoterminal Propeptide, Bone Alkaline Phosphatase, Osteocalcin, and C-Terminal Telopeptide Of Type I Collagen peaked at 1 to 3 years of age and gradually decreased with age, leveling off by 10 years of age. Estradiol, parathyroid hormone, and 25 hydroxyvitamin D, follicle-stimulating hormone, luteinizing hormone, were not significantly different among age groups.ConclusionThis paper provides data on trends in bone turnover markers throughout the life cycle of female cynomolgus monkeys, which are similar to human changes. |
| first_indexed | 2024-04-11T17:03:49Z |
| format | Article |
| id | doaj.art-a262cb297cb84c87b61a7e315f6d3495 |
| institution | Directory Open Access Journal |
| issn | 1664-2392 |
| language | English |
| last_indexed | 2024-04-11T17:03:49Z |
| publishDate | 2022-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj.art-a262cb297cb84c87b61a7e315f6d34952022-12-22T04:13:05ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922022-10-011310.3389/fendo.2022.984523984523Analysis of serum bone turnover markers in female cynomolgus monkeys of different agesYing LiQijun CaiChenchen DongLu HouYingxin LiBin GuoChunyuan ZengYong ChengJingjie ShangXueying LingJian GongHao XuObjectiveThe purpose of this study was to examine bone turnover markers, estradiol, parathyroid hormone, and 25 hydroxyvitamin D, in cynomolgus monkeys at different ages to improve our understanding of the changes in bone turnover markers throughout the life cycle of cynomolgus monkeys and to provide a basis for the establishment of a non-human primate model of osteoporosis.MethodsTotal Body Bone Mineral Density and Total Body Bone Mineral Content were measured using Dual-Energy X-Ray Absorptiometry in cynomolgus monkeys at different ages. Serum bone turnover marker' levels were measured using enzyme immunoassays at each age group, and the relationship between bone turnover markers and age was assessed by Spearman rank correlation analysis to investigate the relationship between bone turnover markers and age in female cynomolgus monkeys.ResultsTotal Body Bone Mineral Density in female cynomolgus monkeys peaked at 10 years of age and then formed a plateau that was maintained until old age. Procollagen I Aminoterminal Propeptide, Bone Alkaline Phosphatase, Osteocalcin, and C-Terminal Telopeptide Of Type I Collagen peaked at 1 to 3 years of age and gradually decreased with age, leveling off by 10 years of age. Estradiol, parathyroid hormone, and 25 hydroxyvitamin D, follicle-stimulating hormone, luteinizing hormone, were not significantly different among age groups.ConclusionThis paper provides data on trends in bone turnover markers throughout the life cycle of female cynomolgus monkeys, which are similar to human changes.https://www.frontiersin.org/articles/10.3389/fendo.2022.984523/fullcynomolgus monkeysnonhuman primatesbone turnover markersestradiolage-related bone loss |
| spellingShingle | Ying Li Qijun Cai Chenchen Dong Lu Hou Yingxin Li Bin Guo Chunyuan Zeng Yong Cheng Jingjie Shang Xueying Ling Jian Gong Hao Xu Analysis of serum bone turnover markers in female cynomolgus monkeys of different ages Frontiers in Endocrinology cynomolgus monkeys nonhuman primates bone turnover markers estradiol age-related bone loss |
| title | Analysis of serum bone turnover markers in female cynomolgus monkeys of different ages |
| title_full | Analysis of serum bone turnover markers in female cynomolgus monkeys of different ages |
| title_fullStr | Analysis of serum bone turnover markers in female cynomolgus monkeys of different ages |
| title_full_unstemmed | Analysis of serum bone turnover markers in female cynomolgus monkeys of different ages |
| title_short | Analysis of serum bone turnover markers in female cynomolgus monkeys of different ages |
| title_sort | analysis of serum bone turnover markers in female cynomolgus monkeys of different ages |
| topic | cynomolgus monkeys nonhuman primates bone turnover markers estradiol age-related bone loss |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2022.984523/full |
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