Comparative Evidence of an Exceptional Impact of Gene Duplication on the Developmental Evolution of Drosophila and the Higher Diptera
The importance of gene duplication in developmental body plan evolution is well-established, but for many megadiverse clades such as true flies (Diptera), a comprehensive understanding is still just emerging through comparative genomics. In a survey of 377 developmental gene families, we found that...
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Frontiers Media S.A.
2018-06-01
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| Series: | Frontiers in Ecology and Evolution |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fevo.2018.00063/full |
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| author | Riyue Bao Sammy E. Dia Hussein A. Issa Dalia Alhusein Markus Friedrich Markus Friedrich |
| author_facet | Riyue Bao Sammy E. Dia Hussein A. Issa Dalia Alhusein Markus Friedrich Markus Friedrich |
| author_sort | Riyue Bao |
| collection | DOAJ |
| description | The importance of gene duplication in developmental body plan evolution is well-established, but for many megadiverse clades such as true flies (Diptera), a comprehensive understanding is still just emerging through comparative genomics. In a survey of 377 developmental gene families, we found that in addition to the pea aphid, which has been previously shown to be genome-wide enriched with gene duplicates and was included as positive control, more than twice as many expanded developmental gene families were observed in Drosophila (49) compared to mosquito (21), flour beetle (20), and honeybee (14). Synonymous sequence divergence estimates and ortholog conservation analyses in additional dipteran genomes revealed that most Drosophila gene duplicates are ancient and accumulated during a time window that reaches back to the origin of brachyceran flies, ~180 million years ago. Further, available genetic data suggest that more than half of the Drosophila developmental gene duplicates remained partially or even fully redundant despite their ancient separation. We therefore speculate that the exceptional accumulation of developmental gene duplicates in Drosophila and the higher Diptera was proximally driven by the evolution of fast development, benefiting from increased genetic robustness. At the same time, the concomitant increase of opportunities for gene duplicate diversification appears to have been a source for developmental and phenotypic innovation during the unparalleled diversification of brachyceran Diptera. |
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| format | Article |
| id | doaj.art-a263e07b0a3849d99c313e4a05e02ca5 |
| institution | Directory Open Access Journal |
| issn | 2296-701X |
| language | English |
| last_indexed | 2024-12-21T20:01:31Z |
| publishDate | 2018-06-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Ecology and Evolution |
| spelling | doaj.art-a263e07b0a3849d99c313e4a05e02ca52022-12-21T18:51:58ZengFrontiers Media S.A.Frontiers in Ecology and Evolution2296-701X2018-06-01610.3389/fevo.2018.00063322427Comparative Evidence of an Exceptional Impact of Gene Duplication on the Developmental Evolution of Drosophila and the Higher DipteraRiyue Bao0Sammy E. Dia1Hussein A. Issa2Dalia Alhusein3Markus Friedrich4Markus Friedrich5Department of Biological Sciences, Wayne State University, Detroit, MI, United StatesDepartment of Biological Sciences, Wayne State University, Detroit, MI, United StatesDepartment of Biological Sciences, Wayne State University, Detroit, MI, United StatesDepartment of Biological Sciences, Wayne State University, Detroit, MI, United StatesDepartment of Biological Sciences, Wayne State University, Detroit, MI, United StatesDepartment of Anatomy and Cell Biology, School of Medicine, Wayne State University, Detroit, MI, United StatesThe importance of gene duplication in developmental body plan evolution is well-established, but for many megadiverse clades such as true flies (Diptera), a comprehensive understanding is still just emerging through comparative genomics. In a survey of 377 developmental gene families, we found that in addition to the pea aphid, which has been previously shown to be genome-wide enriched with gene duplicates and was included as positive control, more than twice as many expanded developmental gene families were observed in Drosophila (49) compared to mosquito (21), flour beetle (20), and honeybee (14). Synonymous sequence divergence estimates and ortholog conservation analyses in additional dipteran genomes revealed that most Drosophila gene duplicates are ancient and accumulated during a time window that reaches back to the origin of brachyceran flies, ~180 million years ago. Further, available genetic data suggest that more than half of the Drosophila developmental gene duplicates remained partially or even fully redundant despite their ancient separation. We therefore speculate that the exceptional accumulation of developmental gene duplicates in Drosophila and the higher Diptera was proximally driven by the evolution of fast development, benefiting from increased genetic robustness. At the same time, the concomitant increase of opportunities for gene duplicate diversification appears to have been a source for developmental and phenotypic innovation during the unparalleled diversification of brachyceran Diptera.https://www.frontiersin.org/article/10.3389/fevo.2018.00063/fullgene duplicationBrachyceraevolution of developmentgenetic redundancyphenotypic robustnessdisconnected |
| spellingShingle | Riyue Bao Sammy E. Dia Hussein A. Issa Dalia Alhusein Markus Friedrich Markus Friedrich Comparative Evidence of an Exceptional Impact of Gene Duplication on the Developmental Evolution of Drosophila and the Higher Diptera Frontiers in Ecology and Evolution gene duplication Brachycera evolution of development genetic redundancy phenotypic robustness disconnected |
| title | Comparative Evidence of an Exceptional Impact of Gene Duplication on the Developmental Evolution of Drosophila and the Higher Diptera |
| title_full | Comparative Evidence of an Exceptional Impact of Gene Duplication on the Developmental Evolution of Drosophila and the Higher Diptera |
| title_fullStr | Comparative Evidence of an Exceptional Impact of Gene Duplication on the Developmental Evolution of Drosophila and the Higher Diptera |
| title_full_unstemmed | Comparative Evidence of an Exceptional Impact of Gene Duplication on the Developmental Evolution of Drosophila and the Higher Diptera |
| title_short | Comparative Evidence of an Exceptional Impact of Gene Duplication on the Developmental Evolution of Drosophila and the Higher Diptera |
| title_sort | comparative evidence of an exceptional impact of gene duplication on the developmental evolution of drosophila and the higher diptera |
| topic | gene duplication Brachycera evolution of development genetic redundancy phenotypic robustness disconnected |
| url | https://www.frontiersin.org/article/10.3389/fevo.2018.00063/full |
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