Progress, Opportunities, and Challenges of Magneto-Plasmonic Nanoparticles under Remote Magnetic and Light Stimulation for Brain-Tissue and Cellular Regeneration
Finding curable therapies for neurodegenerative disease (ND) is still a worldwide medical and clinical challenge. Recently, investigations have been made into the development of novel therapeutic techniques, and examples include the remote stimulation of nanocarriers to deliver neuroprotective drugs...
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| Format: | Article |
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MDPI AG
2022-06-01
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| Series: | Nanomaterials |
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| Online Access: | https://www.mdpi.com/2079-4991/12/13/2242 |
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| author | Muzhaozi Yuan Mackenzie Caitlin Harnett Tian-Hao Yan Elias Georgas Yi-Xian Qin Hong-Cai Zhou Ya Wang |
| author_facet | Muzhaozi Yuan Mackenzie Caitlin Harnett Tian-Hao Yan Elias Georgas Yi-Xian Qin Hong-Cai Zhou Ya Wang |
| author_sort | Muzhaozi Yuan |
| collection | DOAJ |
| description | Finding curable therapies for neurodegenerative disease (ND) is still a worldwide medical and clinical challenge. Recently, investigations have been made into the development of novel therapeutic techniques, and examples include the remote stimulation of nanocarriers to deliver neuroprotective drugs, genes, growth factors, and antibodies using a magnetic field and/or low-power lights. Among these potential nanocarriers, magneto-plasmonic nanoparticles possess obvious advantages, such as the functional restoration of ND models, due to their unique nanostructure and physiochemical properties. In this review, we provide an overview of the latest advances in magneto-plasmonic nanoparticles, and the associated therapeutic approaches to repair and restore brain tissues. We have reviewed their potential as smart nanocarriers, including their unique responsivity under remote magnetic and light stimulation for the controlled and sustained drug delivery for reversing neurodegenerations, as well as the utilization of brain organoids in studying the interaction between NPs and neuronal tissue. This review aims to provide a comprehensive summary of the current progress, opportunities, and challenges of using these smart nanocarriers for programmable therapeutics to treat ND, and predict the mechanism and future directions. |
| first_indexed | 2024-03-09T12:42:04Z |
| format | Article |
| id | doaj.art-a266da9606f7411aad532c5f02cca275 |
| institution | Directory Open Access Journal |
| issn | 2079-4991 |
| language | English |
| last_indexed | 2024-03-09T12:42:04Z |
| publishDate | 2022-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nanomaterials |
| spelling | doaj.art-a266da9606f7411aad532c5f02cca2752023-11-30T22:16:46ZengMDPI AGNanomaterials2079-49912022-06-011213224210.3390/nano12132242Progress, Opportunities, and Challenges of Magneto-Plasmonic Nanoparticles under Remote Magnetic and Light Stimulation for Brain-Tissue and Cellular RegenerationMuzhaozi Yuan0Mackenzie Caitlin Harnett1Tian-Hao Yan2Elias Georgas3Yi-Xian Qin4Hong-Cai Zhou5Ya Wang6J. Mike Walker ‘66 Department of Mechanical Engineering, Texas A&M University, College Station, TX 77843, USAJ. Mike Walker ‘66 Department of Mechanical Engineering, Texas A&M University, College Station, TX 77843, USADepartment of Chemistry, Texas A&M University, College Station, TX 77843, USADepartment of Biomedical Engineering, State University of New York, Stony Brook, NY 11794-5281, USADepartment of Biomedical Engineering, State University of New York, Stony Brook, NY 11794-5281, USADepartment of Chemistry, Texas A&M University, College Station, TX 77843, USAJ. Mike Walker ‘66 Department of Mechanical Engineering, Texas A&M University, College Station, TX 77843, USAFinding curable therapies for neurodegenerative disease (ND) is still a worldwide medical and clinical challenge. Recently, investigations have been made into the development of novel therapeutic techniques, and examples include the remote stimulation of nanocarriers to deliver neuroprotective drugs, genes, growth factors, and antibodies using a magnetic field and/or low-power lights. Among these potential nanocarriers, magneto-plasmonic nanoparticles possess obvious advantages, such as the functional restoration of ND models, due to their unique nanostructure and physiochemical properties. In this review, we provide an overview of the latest advances in magneto-plasmonic nanoparticles, and the associated therapeutic approaches to repair and restore brain tissues. We have reviewed their potential as smart nanocarriers, including their unique responsivity under remote magnetic and light stimulation for the controlled and sustained drug delivery for reversing neurodegenerations, as well as the utilization of brain organoids in studying the interaction between NPs and neuronal tissue. This review aims to provide a comprehensive summary of the current progress, opportunities, and challenges of using these smart nanocarriers for programmable therapeutics to treat ND, and predict the mechanism and future directions.https://www.mdpi.com/2079-4991/12/13/2242magneto-plasmonic nanoparticlesneurodegenerative diseasemagnetic fieldlight stimulationcontrolled and sustained drug releasebrain organoid |
| spellingShingle | Muzhaozi Yuan Mackenzie Caitlin Harnett Tian-Hao Yan Elias Georgas Yi-Xian Qin Hong-Cai Zhou Ya Wang Progress, Opportunities, and Challenges of Magneto-Plasmonic Nanoparticles under Remote Magnetic and Light Stimulation for Brain-Tissue and Cellular Regeneration Nanomaterials magneto-plasmonic nanoparticles neurodegenerative disease magnetic field light stimulation controlled and sustained drug release brain organoid |
| title | Progress, Opportunities, and Challenges of Magneto-Plasmonic Nanoparticles under Remote Magnetic and Light Stimulation for Brain-Tissue and Cellular Regeneration |
| title_full | Progress, Opportunities, and Challenges of Magneto-Plasmonic Nanoparticles under Remote Magnetic and Light Stimulation for Brain-Tissue and Cellular Regeneration |
| title_fullStr | Progress, Opportunities, and Challenges of Magneto-Plasmonic Nanoparticles under Remote Magnetic and Light Stimulation for Brain-Tissue and Cellular Regeneration |
| title_full_unstemmed | Progress, Opportunities, and Challenges of Magneto-Plasmonic Nanoparticles under Remote Magnetic and Light Stimulation for Brain-Tissue and Cellular Regeneration |
| title_short | Progress, Opportunities, and Challenges of Magneto-Plasmonic Nanoparticles under Remote Magnetic and Light Stimulation for Brain-Tissue and Cellular Regeneration |
| title_sort | progress opportunities and challenges of magneto plasmonic nanoparticles under remote magnetic and light stimulation for brain tissue and cellular regeneration |
| topic | magneto-plasmonic nanoparticles neurodegenerative disease magnetic field light stimulation controlled and sustained drug release brain organoid |
| url | https://www.mdpi.com/2079-4991/12/13/2242 |
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