FGF2 Inhibits Early Pancreatic Lineage Specification during Differentiation of Human Embryonic Stem Cells

FGF2 Inhibits Early Pancreatic Lineage Specification during Differentiation of Human Embryonic Stem Cells

Growth factors are important regulators during organ development. For many vertebrates (but not humans) it is known how they contribute to the formation and expansion of PDX1-positive cells during pancreas organogenesis. Here, the effects of the fibroblast growth factors FGF2, FGF7, FGF10, and epide...

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Bibliographic Details
Main Authors: Rabea Dettmer, Karsten Cirksena, Julia Münchhoff, Jasmin Kresse, Ulf Diekmann, Isabell Niwolik, Falk F. R. Buettner, Ortwin Naujok
Format: Article
Language:English
Published: MDPI AG 2020-08-01
Series:Cells
Subjects:
human pluripotent stem cells
pancreas organogenesis
secretomics
PDX1
Online Access:https://www.mdpi.com/2073-4409/9/9/1927

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