Halofantrine Hydrochloride (Halfan) Induced Toxicity of the Pancreas in Wistar Rats
The toxicity of halofantrine hydrochloride to the pancreas of wistar rats (Rattus norvegicus) was studied using twenty five male wistar rats divided into five groups of five rats per group. Group A (control group) was given only clean water. Groups B. C. D and E received 0.7; 1.4; 2.1 and 2. 8g/kg B...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Joint Coordination Centre of the World Bank assisted National Agricultural Research Programme (NARP)
2009-10-01
|
| Series: | Journal of Applied Sciences and Environmental Management |
| Online Access: | https://www.ajol.info/index.php/jasem/article/view/46838 |
| _version_ | 1797227715508568064 |
|---|---|
| author | BC Didia EB Dede AO Obianime |
| author_facet | BC Didia EB Dede AO Obianime |
| author_sort | BC Didia |
| collection | DOAJ |
| description | The toxicity of halofantrine hydrochloride to the pancreas of wistar rats (Rattus norvegicus) was studied using twenty five male wistar rats divided into five groups of five rats per group. Group A (control group) was given only clean water. Groups B. C. D and E received 0.7; 1.4; 2.1 and 2. 8g/kg Body not of halofantrine hydrochloride administered orally every six hours for three times (complete dose) respectively. The results showed Odema and swelling of pancreatic acini cells and obliteration of interstitial spaces. This toxicity effect was found to be dose dependent and significantly different from the normal integrity of the cells observed in the control experiment: The result underscored a possible toxic effect halofantrine when administered into man. Based on the result obtained, there was need for caution on the use of halfan in the treatment of malaria, particularly in cases of drug abuse. It is suggested that further studies are required to elucidate the implication of this toxicity to both the endocrine and exocrine functions of the pancreas |
| first_indexed | 2024-04-24T14:45:12Z |
| format | Article |
| id | doaj.art-a26ded12fbd7439a858aa1c6fa099035 |
| institution | Directory Open Access Journal |
| issn | 2659-1502 2659-1499 |
| language | English |
| last_indexed | 2024-04-24T14:45:12Z |
| publishDate | 2009-10-01 |
| publisher | Joint Coordination Centre of the World Bank assisted National Agricultural Research Programme (NARP) |
| record_format | Article |
| series | Journal of Applied Sciences and Environmental Management |
| spelling | doaj.art-a26ded12fbd7439a858aa1c6fa0990352024-04-02T19:57:53ZengJoint Coordination Centre of the World Bank assisted National Agricultural Research Programme (NARP)Journal of Applied Sciences and Environmental Management2659-15022659-14992009-10-0111110.4314/jasem.v11i1.46838Halofantrine Hydrochloride (Halfan) Induced Toxicity of the Pancreas in Wistar RatsBC DidiaEB DedeAO ObianimeThe toxicity of halofantrine hydrochloride to the pancreas of wistar rats (Rattus norvegicus) was studied using twenty five male wistar rats divided into five groups of five rats per group. Group A (control group) was given only clean water. Groups B. C. D and E received 0.7; 1.4; 2.1 and 2. 8g/kg Body not of halofantrine hydrochloride administered orally every six hours for three times (complete dose) respectively. The results showed Odema and swelling of pancreatic acini cells and obliteration of interstitial spaces. This toxicity effect was found to be dose dependent and significantly different from the normal integrity of the cells observed in the control experiment: The result underscored a possible toxic effect halofantrine when administered into man. Based on the result obtained, there was need for caution on the use of halfan in the treatment of malaria, particularly in cases of drug abuse. It is suggested that further studies are required to elucidate the implication of this toxicity to both the endocrine and exocrine functions of the pancreashttps://www.ajol.info/index.php/jasem/article/view/46838 |
| spellingShingle | BC Didia EB Dede AO Obianime Halofantrine Hydrochloride (Halfan) Induced Toxicity of the Pancreas in Wistar Rats Journal of Applied Sciences and Environmental Management |
| title | Halofantrine Hydrochloride (Halfan) Induced Toxicity of the Pancreas in Wistar Rats |
| title_full | Halofantrine Hydrochloride (Halfan) Induced Toxicity of the Pancreas in Wistar Rats |
| title_fullStr | Halofantrine Hydrochloride (Halfan) Induced Toxicity of the Pancreas in Wistar Rats |
| title_full_unstemmed | Halofantrine Hydrochloride (Halfan) Induced Toxicity of the Pancreas in Wistar Rats |
| title_short | Halofantrine Hydrochloride (Halfan) Induced Toxicity of the Pancreas in Wistar Rats |
| title_sort | halofantrine hydrochloride halfan induced toxicity of the pancreas in wistar rats |
| url | https://www.ajol.info/index.php/jasem/article/view/46838 |
| work_keys_str_mv | AT bcdidia halofantrinehydrochloridehalfaninducedtoxicityofthepancreasinwistarrats AT ebdede halofantrinehydrochloridehalfaninducedtoxicityofthepancreasinwistarrats AT aoobianime halofantrinehydrochloridehalfaninducedtoxicityofthepancreasinwistarrats |