Local chromatin fiber folding represses transcription and loop extrusion in quiescent cells

Local chromatin fiber folding represses transcription and loop extrusion in quiescent cells

A longstanding hypothesis is that chromatin fiber folding mediated by interactions between nearby nucleosomes represses transcription. However, it has been difficult to determine the relationship between local chromatin fiber compaction and transcription in cells. Further, global changes in fiber di...

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Bibliographic Details
Main Authors: Sarah G Swygert, Dejun Lin, Stephanie Portillo-Ledesma, Po-Yen Lin, Dakota R Hunt, Cheng-Fu Kao, Tamar Schlick, William S Noble, Toshio Tsukiyama
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2021-11-01
Series:eLife
Subjects:
nucleosome
chromatin
micro-c
transcription
condensin
quiescence
Online Access:https://elifesciences.org/articles/72062

Internet

https://elifesciences.org/articles/72062

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