Histology of metastatic colorectal cancer in a lymph node
<h4>Background</h4> A primary colorectal cancer (CRC) tumor can contain heterogeneous cancer cells. As clones of cells with different properties metastasize to lymph nodes (LNs), they could show different morphologies. Cancer histologies in LNs of CRC remains to be described. <h4>M...
| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2023-01-01
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| Series: | PLoS ONE |
| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10101456/?tool=EBI |
| _version_ | 1827966552826183680 |
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| author | Shozo Yokoyama Takashi Watanabe Yoichi Fujita Shuichi Matsumura Katsuya Ueda Shotaro Nagano Ikuharu Kinoshita Daisuke Murakami Hirotaka Tabata Toshiaki Tsuji Satoru Ozawa Takuya Tamaki Yoshihiro Nakatani Masami Oka |
| author_facet | Shozo Yokoyama Takashi Watanabe Yoichi Fujita Shuichi Matsumura Katsuya Ueda Shotaro Nagano Ikuharu Kinoshita Daisuke Murakami Hirotaka Tabata Toshiaki Tsuji Satoru Ozawa Takuya Tamaki Yoshihiro Nakatani Masami Oka |
| author_sort | Shozo Yokoyama |
| collection | DOAJ |
| description | <h4>Background</h4> A primary colorectal cancer (CRC) tumor can contain heterogeneous cancer cells. As clones of cells with different properties metastasize to lymph nodes (LNs), they could show different morphologies. Cancer histologies in LNs of CRC remains to be described. <h4>Methods</h4> Our study enrolled 318 consecutive patients with CRC who underwent primary tumor resection with lymph node dissection between January 2011 and June 2016. 119 (37.4%) patients who had metastatic LNs (mLNs) were finally included in this study. Cancer histologies in LNs were classified and compared with pathologically diagnosed differentiation in the primary lesion. The association between histologies in lymph node metastasis (LNM) and prognosis in patients with CRC was investigated. <h4>Results</h4> The histologies of the cancer cells in the mLNs were classified into four types: tubular, cribriform, poorly differentiated, and mucinous. Same degree of pathologically diagnosed differentiation in the primary tumor produced various histological types in LNM. In Kaplan–Meier analysis, prognosis was worse in CRC patients with moderately differentiated adenocarcinoma who had at least some mLN also showing cribriform carcinoma than for those whose mLNs all showed tubular carcinoma. <h4>Conclusions</h4> Histology in LNM from CRC might indicate the heterogeneity and malignant phenotype of the disease. |
| first_indexed | 2024-04-09T17:50:40Z |
| format | Article |
| id | doaj.art-a2716e2d2f8e483d93ee46af1e6b3eef |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-04-09T17:50:40Z |
| publishDate | 2023-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-a2716e2d2f8e483d93ee46af1e6b3eef2023-04-16T05:31:46ZengPublic Library of Science (PLoS)PLoS ONE1932-62032023-01-01184Histology of metastatic colorectal cancer in a lymph nodeShozo YokoyamaTakashi WatanabeYoichi FujitaShuichi MatsumuraKatsuya UedaShotaro NaganoIkuharu KinoshitaDaisuke MurakamiHirotaka TabataToshiaki TsujiSatoru OzawaTakuya TamakiYoshihiro NakataniMasami Oka<h4>Background</h4> A primary colorectal cancer (CRC) tumor can contain heterogeneous cancer cells. As clones of cells with different properties metastasize to lymph nodes (LNs), they could show different morphologies. Cancer histologies in LNs of CRC remains to be described. <h4>Methods</h4> Our study enrolled 318 consecutive patients with CRC who underwent primary tumor resection with lymph node dissection between January 2011 and June 2016. 119 (37.4%) patients who had metastatic LNs (mLNs) were finally included in this study. Cancer histologies in LNs were classified and compared with pathologically diagnosed differentiation in the primary lesion. The association between histologies in lymph node metastasis (LNM) and prognosis in patients with CRC was investigated. <h4>Results</h4> The histologies of the cancer cells in the mLNs were classified into four types: tubular, cribriform, poorly differentiated, and mucinous. Same degree of pathologically diagnosed differentiation in the primary tumor produced various histological types in LNM. In Kaplan–Meier analysis, prognosis was worse in CRC patients with moderately differentiated adenocarcinoma who had at least some mLN also showing cribriform carcinoma than for those whose mLNs all showed tubular carcinoma. <h4>Conclusions</h4> Histology in LNM from CRC might indicate the heterogeneity and malignant phenotype of the disease.https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10101456/?tool=EBI |
| spellingShingle | Shozo Yokoyama Takashi Watanabe Yoichi Fujita Shuichi Matsumura Katsuya Ueda Shotaro Nagano Ikuharu Kinoshita Daisuke Murakami Hirotaka Tabata Toshiaki Tsuji Satoru Ozawa Takuya Tamaki Yoshihiro Nakatani Masami Oka Histology of metastatic colorectal cancer in a lymph node PLoS ONE |
| title | Histology of metastatic colorectal cancer in a lymph node |
| title_full | Histology of metastatic colorectal cancer in a lymph node |
| title_fullStr | Histology of metastatic colorectal cancer in a lymph node |
| title_full_unstemmed | Histology of metastatic colorectal cancer in a lymph node |
| title_short | Histology of metastatic colorectal cancer in a lymph node |
| title_sort | histology of metastatic colorectal cancer in a lymph node |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10101456/?tool=EBI |
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