Clickable Cisplatin Derivatives as Versatile Tools to Probe the DNA Damage Response to Chemotherapy

Clickable Cisplatin Derivatives as Versatile Tools to Probe the DNA Damage Response to Chemotherapy

Cisplatin induces DNA crosslinks that are highly cytotoxic. Hence, platinum complexes are frequently used in the treatment of a broad range of cancers. Efficiency of cisplatin treatment is limited by the tumor-specific DNA damage response to the generated lesions. We reasoned that better tools to in...

Full description

Bibliographic Details
Main Authors: Amandine Moretton, Jana Slyskova, Marwan E. Simaan, Emili A. Arasa-Verge, Mathilde Meyenberg, D. Alonso Cerrón-Infantes, Miriam M. Unterlass, Joanna I. Loizou
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-06-01
Series:Frontiers in Oncology
Subjects:
cisplatin
chemotherapy
chemoresistance
DNA Damage
DNA crosslinks
DNA repair
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2022.874201/full

Similar Items

Similar Items