Acute myeloid leukemia: challenges for diagnosis and treatment in Latin America
ABSTRACTObjective to review the current diagnostic and therapeutic landscape of AML in Latin America as a reflection of other low- and middle-income countries and regions of the world. Encompassing both acute promyelocytic and non-promyelocytic disease types.Methods We reviewed the literature and st...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2023-12-01
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| Series: | Hematology |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/16078454.2022.2158015 |
| _version_ | 1797959922282921984 |
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| author | Andrés Gómez-De León Roberta Demichelis-Gómez Abel da Costa-Neto David Gómez-Almaguer Eduardo Magalhães Rego |
| author_facet | Andrés Gómez-De León Roberta Demichelis-Gómez Abel da Costa-Neto David Gómez-Almaguer Eduardo Magalhães Rego |
| author_sort | Andrés Gómez-De León |
| collection | DOAJ |
| description | ABSTRACTObjective to review the current diagnostic and therapeutic landscape of AML in Latin America as a reflection of other low- and middle-income countries and regions of the world. Encompassing both acute promyelocytic and non-promyelocytic disease types.Methods We reviewed the literature and study registries concerning epidemiological features of patients with AML/APL treated in Latin America, as well as evaluated diagnostic and genetic stratification and patient fitness assessment challenges, the importance of early mortality and supportive care capacity, intensive and non-intensive chemotherapy alternatives, consolidation, and maintenance strategies including novel agents and hematopoietic stem cell transplantation.Results Although most of the current technologies and treatment options are available in the region, a significant fraction of patients have only limited access to them. In addition, mortality in the first weeks from diagnosis is higher in the region compared to developed countries.Conclusions Disparities in access to technologies, supportive care capacity, and availability of novel agents and HSCT hinder results in our region, reflecting barriers common to other LMICs. Recent developments in the diagnosis and treatment of this disease must be implemented through education, collaborative clinical research, and advocacy to improve outcomes. |
| first_indexed | 2024-04-11T00:38:21Z |
| format | Article |
| id | doaj.art-a272cf46fbfa4d28adb0892bac387f25 |
| institution | Directory Open Access Journal |
| issn | 1607-8454 |
| language | English |
| last_indexed | 2024-04-11T00:38:21Z |
| publishDate | 2023-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Hematology |
| spelling | doaj.art-a272cf46fbfa4d28adb0892bac387f252023-01-06T14:19:33ZengTaylor & Francis GroupHematology1607-84542023-12-0128110.1080/16078454.2022.2158015Acute myeloid leukemia: challenges for diagnosis and treatment in Latin AmericaAndrés Gómez-De León0Roberta Demichelis-Gómez1Abel da Costa-Neto2David Gómez-Almaguer3Eduardo Magalhães Rego4Facultad de Medicina y Hospital Universitario “Dr. José Eleuterio González”, Universiadad Autónoma de Nuevo León, Monterrey, MexicoDepartment of Hematology, Instituto Nacional de Cinecias Médicas y Nutrición Salvador Zubirán, Mexico City, MexicoDepartment of Hematology, D’or Institute for Research and Education, São Paulo, BrazilFacultad de Medicina y Hospital Universitario “Dr. José Eleuterio González”, Universiadad Autónoma de Nuevo León, Monterrey, MexicoFacultad de Medicina de Ribeirāo Preto, Universidad de São Paulo, São Paulo, BrazilABSTRACTObjective to review the current diagnostic and therapeutic landscape of AML in Latin America as a reflection of other low- and middle-income countries and regions of the world. Encompassing both acute promyelocytic and non-promyelocytic disease types.Methods We reviewed the literature and study registries concerning epidemiological features of patients with AML/APL treated in Latin America, as well as evaluated diagnostic and genetic stratification and patient fitness assessment challenges, the importance of early mortality and supportive care capacity, intensive and non-intensive chemotherapy alternatives, consolidation, and maintenance strategies including novel agents and hematopoietic stem cell transplantation.Results Although most of the current technologies and treatment options are available in the region, a significant fraction of patients have only limited access to them. In addition, mortality in the first weeks from diagnosis is higher in the region compared to developed countries.Conclusions Disparities in access to technologies, supportive care capacity, and availability of novel agents and HSCT hinder results in our region, reflecting barriers common to other LMICs. Recent developments in the diagnosis and treatment of this disease must be implemented through education, collaborative clinical research, and advocacy to improve outcomes.https://www.tandfonline.com/doi/10.1080/16078454.2022.2158015Acute myeloid luekemiaacute promyelocytic leukemiaLatinamericahematopoietic stem cell transplantationvenetoclaxATRA |
| spellingShingle | Andrés Gómez-De León Roberta Demichelis-Gómez Abel da Costa-Neto David Gómez-Almaguer Eduardo Magalhães Rego Acute myeloid leukemia: challenges for diagnosis and treatment in Latin America Hematology Acute myeloid luekemia acute promyelocytic leukemia Latinamerica hematopoietic stem cell transplantation venetoclax ATRA |
| title | Acute myeloid leukemia: challenges for diagnosis and treatment in Latin America |
| title_full | Acute myeloid leukemia: challenges for diagnosis and treatment in Latin America |
| title_fullStr | Acute myeloid leukemia: challenges for diagnosis and treatment in Latin America |
| title_full_unstemmed | Acute myeloid leukemia: challenges for diagnosis and treatment in Latin America |
| title_short | Acute myeloid leukemia: challenges for diagnosis and treatment in Latin America |
| title_sort | acute myeloid leukemia challenges for diagnosis and treatment in latin america |
| topic | Acute myeloid luekemia acute promyelocytic leukemia Latinamerica hematopoietic stem cell transplantation venetoclax ATRA |
| url | https://www.tandfonline.com/doi/10.1080/16078454.2022.2158015 |
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