Role of intestinal microbiota in the development of celiac disease
The article reviews latest data on the role of additional factors of celiac disease, in particular, intestinal microbiota. Composition of intestinal biocenosis of patients with celiac disease is characterized by increase in gram-negative bacteria and decrease in obligatory germs, specifically, bifid...
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| Format: | Article |
| Language: | Russian |
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Remedium Group LLC
2013-12-01
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| Series: | Медицинский совет |
| Subjects: | |
| Online Access: | https://www.med-sovet.pro/jour/article/view/857 |
| _version_ | 1827962289310924800 |
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| author | E. A. Kornienko |
| author_facet | E. A. Kornienko |
| author_sort | E. A. Kornienko |
| collection | DOAJ |
| description | The article reviews latest data on the role of additional factors of celiac disease, in particular, intestinal microbiota. Composition of intestinal biocenosis of patients with celiac disease is characterized by increase in gram-negative bacteria and decrease in obligatory germs, specifically, bifid bacteria. Dynamic studies showed incomplete recovery at gluten-free diet. Microbiota formation in children with genetic risk of celiacia differs from that of healthy children in being less diverse in species, lower number of bacteroids, lack of short-chain fatty acid and excess lactate. This may increase permeability of intestinal barrier and maintain inflammation, while preventing from developing immunological tolerance to gluten. |
| first_indexed | 2024-04-09T16:40:25Z |
| format | Article |
| id | doaj.art-a274f7d45f3b4edd88550de94afe05a3 |
| institution | Directory Open Access Journal |
| issn | 2079-701X 2658-5790 |
| language | Russian |
| last_indexed | 2024-04-09T16:40:25Z |
| publishDate | 2013-12-01 |
| publisher | Remedium Group LLC |
| record_format | Article |
| series | Медицинский совет |
| spelling | doaj.art-a274f7d45f3b4edd88550de94afe05a32023-04-23T06:56:44ZrusRemedium Group LLCМедицинский совет2079-701X2658-57902013-12-0101445110.21518/2079-701X-2013-1-44-51857Role of intestinal microbiota in the development of celiac diseaseE. A. Kornienko0ФПК и ПП, Санкт-Петербургский государственный педиатрический медицинский университетThe article reviews latest data on the role of additional factors of celiac disease, in particular, intestinal microbiota. Composition of intestinal biocenosis of patients with celiac disease is characterized by increase in gram-negative bacteria and decrease in obligatory germs, specifically, bifid bacteria. Dynamic studies showed incomplete recovery at gluten-free diet. Microbiota formation in children with genetic risk of celiacia differs from that of healthy children in being less diverse in species, lower number of bacteroids, lack of short-chain fatty acid and excess lactate. This may increase permeability of intestinal barrier and maintain inflammation, while preventing from developing immunological tolerance to gluten.https://www.med-sovet.pro/jour/article/view/857целиакиятолерантность к глютенукишечная микробиотаceliac diseasetolerance to glutenintestinal microbiota |
| spellingShingle | E. A. Kornienko Role of intestinal microbiota in the development of celiac disease Медицинский совет целиакия толерантность к глютену кишечная микробиота celiac disease tolerance to gluten intestinal microbiota |
| title | Role of intestinal microbiota in the development of celiac disease |
| title_full | Role of intestinal microbiota in the development of celiac disease |
| title_fullStr | Role of intestinal microbiota in the development of celiac disease |
| title_full_unstemmed | Role of intestinal microbiota in the development of celiac disease |
| title_short | Role of intestinal microbiota in the development of celiac disease |
| title_sort | role of intestinal microbiota in the development of celiac disease |
| topic | целиакия толерантность к глютену кишечная микробиота celiac disease tolerance to gluten intestinal microbiota |
| url | https://www.med-sovet.pro/jour/article/view/857 |
| work_keys_str_mv | AT eakornienko roleofintestinalmicrobiotainthedevelopmentofceliacdisease |