Neuronal and Cerebrovascular Complications in Coronavirus Disease 2019
Coronavirus disease 2019 (COVID-19) is a pandemic disease resulting from severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection, primarily in the respiratory tract. This pandemic disease has affected the entire world, and the pathobiology of this disease is not yet completely known....
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2020-11-01
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| Series: | Frontiers in Pharmacology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2020.570031/full |
| _version_ | 1818408667525939200 |
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| author | Mudasir S. Andrabi Shaida A. Andrabi Shaida A. Andrabi |
| author_facet | Mudasir S. Andrabi Shaida A. Andrabi Shaida A. Andrabi |
| author_sort | Mudasir S. Andrabi |
| collection | DOAJ |
| description | Coronavirus disease 2019 (COVID-19) is a pandemic disease resulting from severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection, primarily in the respiratory tract. This pandemic disease has affected the entire world, and the pathobiology of this disease is not yet completely known. The Interactions of SARS-CoV-2 proteins with different cellular components in the host cell may be necessary for understanding the disease mechanism and identifying crucial pharmacological targets in COVID-19. Studies have suggested that the effect of SARS-CoV-2 on other organs, including the brain, maybe critical for understanding the pathobiology of COVID-19. Symptoms in COVID-19 patients, including impaired consciousness dizziness, headache, loss of taste and smell, vision problems, and neuromuscular pain, suggest that neuronal complications comprise a crucial component of COVID-19 pathobiology. A growing body of literature indicates that SARS-CoV-2 can enter the brain, leading to neuronal defects in COVID-19 patients. Other studies suggest that SARS-CoV-2 may aggravate neuronal complications due to its effects on the cerebrovascular system. Emerging pieces of evidence show that stroke can be one of the leading neurological complications in COVID-19. In this review, we describe the observations about neuronal complications of COVID-19 and how SARS-CoV-2 may invade the brain. We will also discuss the cerebrovascular problems and occurrence of stroke in COVID-19 patients. We will also present the observations and our views about the potential pharmacological strategies and targets in COVID-19. We hope this review will help comprehend the current knowledge of neuronal and cerebrovascular complications from SARS-CoV-2 infections and highlight the possible long-term consequences of SARS-CoV-2 on the human brain. |
| first_indexed | 2024-12-14T09:47:22Z |
| format | Article |
| id | doaj.art-a27561d4c9f646c4bb41f4829ff2731f |
| institution | Directory Open Access Journal |
| issn | 1663-9812 |
| language | English |
| last_indexed | 2024-12-14T09:47:22Z |
| publishDate | 2020-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj.art-a27561d4c9f646c4bb41f4829ff2731f2022-12-21T23:07:36ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122020-11-011110.3389/fphar.2020.570031570031Neuronal and Cerebrovascular Complications in Coronavirus Disease 2019Mudasir S. Andrabi0Shaida A. Andrabi1Shaida A. Andrabi2Capstone College of Nursing, University of Alabama, Tuscaloosa, AL, United StatesDepartment of Pharmacology and Toxicology, University of Alabama at Birmingham School of Medicine, Birmingham, AL, United StatesDepartment of Neurology, University of Alabama at Birmingham School of Medicine, Birmingham, AL, United StatesCoronavirus disease 2019 (COVID-19) is a pandemic disease resulting from severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection, primarily in the respiratory tract. This pandemic disease has affected the entire world, and the pathobiology of this disease is not yet completely known. The Interactions of SARS-CoV-2 proteins with different cellular components in the host cell may be necessary for understanding the disease mechanism and identifying crucial pharmacological targets in COVID-19. Studies have suggested that the effect of SARS-CoV-2 on other organs, including the brain, maybe critical for understanding the pathobiology of COVID-19. Symptoms in COVID-19 patients, including impaired consciousness dizziness, headache, loss of taste and smell, vision problems, and neuromuscular pain, suggest that neuronal complications comprise a crucial component of COVID-19 pathobiology. A growing body of literature indicates that SARS-CoV-2 can enter the brain, leading to neuronal defects in COVID-19 patients. Other studies suggest that SARS-CoV-2 may aggravate neuronal complications due to its effects on the cerebrovascular system. Emerging pieces of evidence show that stroke can be one of the leading neurological complications in COVID-19. In this review, we describe the observations about neuronal complications of COVID-19 and how SARS-CoV-2 may invade the brain. We will also discuss the cerebrovascular problems and occurrence of stroke in COVID-19 patients. We will also present the observations and our views about the potential pharmacological strategies and targets in COVID-19. We hope this review will help comprehend the current knowledge of neuronal and cerebrovascular complications from SARS-CoV-2 infections and highlight the possible long-term consequences of SARS-CoV-2 on the human brain.https://www.frontiersin.org/articles/10.3389/fphar.2020.570031/fullsevere acute respiratory syndrome coronavirus-2coronavirus disease 2019neuronsstrokeangiotensin-converting enzyme 2axonal transport |
| spellingShingle | Mudasir S. Andrabi Shaida A. Andrabi Shaida A. Andrabi Neuronal and Cerebrovascular Complications in Coronavirus Disease 2019 Frontiers in Pharmacology severe acute respiratory syndrome coronavirus-2 coronavirus disease 2019 neurons stroke angiotensin-converting enzyme 2 axonal transport |
| title | Neuronal and Cerebrovascular Complications in Coronavirus Disease 2019 |
| title_full | Neuronal and Cerebrovascular Complications in Coronavirus Disease 2019 |
| title_fullStr | Neuronal and Cerebrovascular Complications in Coronavirus Disease 2019 |
| title_full_unstemmed | Neuronal and Cerebrovascular Complications in Coronavirus Disease 2019 |
| title_short | Neuronal and Cerebrovascular Complications in Coronavirus Disease 2019 |
| title_sort | neuronal and cerebrovascular complications in coronavirus disease 2019 |
| topic | severe acute respiratory syndrome coronavirus-2 coronavirus disease 2019 neurons stroke angiotensin-converting enzyme 2 axonal transport |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2020.570031/full |
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