Impact of a sepsis bundle in wards of a tertiary hospital
Abstract Background Sepsis is a prevalent disease worldwide and still exhibits high rates of mortality. In the last years, many interventions aiming a positive impact on sepsis evolution have been studied. One of the main is the use of managed care protocols (sepsis bundles), which consist in system...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2017-07-01
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| Series: | Journal of Intensive Care |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s40560-017-0231-2 |
| _version_ | 1819043254249717760 |
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| author | F. Teles W. G. Rodrigues M. G. T. C. Alves C. F. T. Albuquerque S. M. O. Bastos M. F. A. Mota E. S. Mota F. J. L. Silva |
| author_facet | F. Teles W. G. Rodrigues M. G. T. C. Alves C. F. T. Albuquerque S. M. O. Bastos M. F. A. Mota E. S. Mota F. J. L. Silva |
| author_sort | F. Teles |
| collection | DOAJ |
| description | Abstract Background Sepsis is a prevalent disease worldwide and still exhibits high rates of mortality. In the last years, many interventions aiming a positive impact on sepsis evolution have been studied. One of the main is the use of managed care protocols (sepsis bundles), which consist in systematization of diagnosis and treatment, such as standardization of antibiotics, collection of specific tests (cultures, lactate), and fluid replacement. Some studies have shown a reduction in hospital costs and lower mortality with the use of these tools. In the present study, we evaluated the impact of a sepsis bundle in wards of a tertiary hospital. Methods One hundred sixty-seven patients were retrospectively studied. The intervention was called “3-h bundle” and consisted of collecting lactate and cultures, start broad-spectrum antibiotics in the first hour of sepsis diagnosis, and volume replacement with crystalloid if hypotension or lactate ≥2 mmol/L. Results The overall mortality was 31.1%. Individuals who received the 3-h bundle showed a 44% lower mortality in comparison with who did not (25.6 vs. 45.7%; p = 0.01). Furthermore, the use of the sepsis bundle was independently correlated with lower mortality (OR = 0.175; CI = 0.04–0.64; p = 0.009). Therefore, a lower need for ICU admission and shorter length of stay in these units were observed in patients who received the intervention. Conclusion The use of a sepsis protocol with systematic care in wards was associated with lower mortality, less need for ICU admission and shorter stay on these units. |
| first_indexed | 2024-12-21T09:53:51Z |
| format | Article |
| id | doaj.art-a275bdc6f1d843d7b5bf768bb22d548e |
| institution | Directory Open Access Journal |
| issn | 2052-0492 |
| language | English |
| last_indexed | 2024-12-21T09:53:51Z |
| publishDate | 2017-07-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Intensive Care |
| spelling | doaj.art-a275bdc6f1d843d7b5bf768bb22d548e2022-12-21T19:08:07ZengBMCJournal of Intensive Care2052-04922017-07-01511510.1186/s40560-017-0231-2Impact of a sepsis bundle in wards of a tertiary hospitalF. Teles0W. G. Rodrigues1M. G. T. C. Alves2C. F. T. Albuquerque3S. M. O. Bastos4M. F. A. Mota5E. S. Mota6F. J. L. Silva7Santa Casa de Misericórdia de MaceióSanta Casa de Misericórdia de MaceióSanta Casa de Misericórdia de MaceióSanta Casa de Misericórdia de MaceióSanta Casa de Misericórdia de MaceióSanta Casa de Misericórdia de MaceióSanta Casa de Misericórdia de MaceióSanta Casa de Misericórdia de MaceióAbstract Background Sepsis is a prevalent disease worldwide and still exhibits high rates of mortality. In the last years, many interventions aiming a positive impact on sepsis evolution have been studied. One of the main is the use of managed care protocols (sepsis bundles), which consist in systematization of diagnosis and treatment, such as standardization of antibiotics, collection of specific tests (cultures, lactate), and fluid replacement. Some studies have shown a reduction in hospital costs and lower mortality with the use of these tools. In the present study, we evaluated the impact of a sepsis bundle in wards of a tertiary hospital. Methods One hundred sixty-seven patients were retrospectively studied. The intervention was called “3-h bundle” and consisted of collecting lactate and cultures, start broad-spectrum antibiotics in the first hour of sepsis diagnosis, and volume replacement with crystalloid if hypotension or lactate ≥2 mmol/L. Results The overall mortality was 31.1%. Individuals who received the 3-h bundle showed a 44% lower mortality in comparison with who did not (25.6 vs. 45.7%; p = 0.01). Furthermore, the use of the sepsis bundle was independently correlated with lower mortality (OR = 0.175; CI = 0.04–0.64; p = 0.009). Therefore, a lower need for ICU admission and shorter length of stay in these units were observed in patients who received the intervention. Conclusion The use of a sepsis protocol with systematic care in wards was associated with lower mortality, less need for ICU admission and shorter stay on these units.http://link.springer.com/article/10.1186/s40560-017-0231-23-h bundleSepsis protocolMortalityWards |
| spellingShingle | F. Teles W. G. Rodrigues M. G. T. C. Alves C. F. T. Albuquerque S. M. O. Bastos M. F. A. Mota E. S. Mota F. J. L. Silva Impact of a sepsis bundle in wards of a tertiary hospital Journal of Intensive Care 3-h bundle Sepsis protocol Mortality Wards |
| title | Impact of a sepsis bundle in wards of a tertiary hospital |
| title_full | Impact of a sepsis bundle in wards of a tertiary hospital |
| title_fullStr | Impact of a sepsis bundle in wards of a tertiary hospital |
| title_full_unstemmed | Impact of a sepsis bundle in wards of a tertiary hospital |
| title_short | Impact of a sepsis bundle in wards of a tertiary hospital |
| title_sort | impact of a sepsis bundle in wards of a tertiary hospital |
| topic | 3-h bundle Sepsis protocol Mortality Wards |
| url | http://link.springer.com/article/10.1186/s40560-017-0231-2 |
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