System dynamics modelling approach to explore the effect of dog demography on rabies vaccination coverage in Africa.
BACKGROUND:Dogs are important reservoirs of rabies, a zoonotic viral encephalitis that kills thousands of people in Asia and Africa annually. Mass dog vaccination is recommended for the prevention of rabies in both humans and dogs. Mass vaccinations should be conducted annually but more frequent cam...
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2018-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC6201891?pdf=render |
| _version_ | 1818512130774663168 |
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| author | Nozyechi Ngulube Chidumayo |
| author_facet | Nozyechi Ngulube Chidumayo |
| author_sort | Nozyechi Ngulube Chidumayo |
| collection | DOAJ |
| description | BACKGROUND:Dogs are important reservoirs of rabies, a zoonotic viral encephalitis that kills thousands of people in Asia and Africa annually. Mass dog vaccination is recommended for the prevention of rabies in both humans and dogs. Mass vaccinations should be conducted annually but more frequent campaigns may be required in areas with high dog turnover rates. Consequently, a good understanding of dog demography is essential for the control of the disease. The aim of this study was to explore the effect of dog demography on rabies vaccination coverage following a mass vaccination campaign with at least 70% vaccination coverage. METHODOLOGY/PRINCIPAL FINDINGS:A dog population model was constructed to explore the effect of dog demography on rabies vaccination coverage decline. Important model parameters were identified through a comprehensive literature search on dog demography in Africa. A system dynamics approach was adopted to build a dog population model to simulate the effects of demographic processes on rabies vaccination coverage. Vensim PLE Plus software was used to construct the model. Multivariate sensitivity simulations using data from 22 studies and 12 African countries were performed to investigate the effect of dog turnover rates on vaccination coverage decline. In addition, an adjusted vaccination coverage to estimate the proportion of vaccinated dogs with adequate immunity at 12 months post-vaccination was calculated. The results demonstrated that the vaccination coverage and adjusted vaccination coverage remained over 30% and 20% respectively at 12 months if annual mass vaccinations achieved at least 70% coverage. CONCLUSIONS/SIGNIFICANCE:The results demonstrated that annual mass vaccination campaigns with at least 70% vaccination coverage would maintain a herd immunity of 20‒45% between campaigns. |
| first_indexed | 2024-12-10T23:42:41Z |
| format | Article |
| id | doaj.art-a27c0cfce3aa491db69d03c45c23ea69 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-10T23:42:41Z |
| publishDate | 2018-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-a27c0cfce3aa491db69d03c45c23ea692022-12-22T01:29:01ZengPublic Library of Science (PLoS)PLoS ONE1932-62032018-01-011310e020588410.1371/journal.pone.0205884System dynamics modelling approach to explore the effect of dog demography on rabies vaccination coverage in Africa.Nozyechi Ngulube ChidumayoBACKGROUND:Dogs are important reservoirs of rabies, a zoonotic viral encephalitis that kills thousands of people in Asia and Africa annually. Mass dog vaccination is recommended for the prevention of rabies in both humans and dogs. Mass vaccinations should be conducted annually but more frequent campaigns may be required in areas with high dog turnover rates. Consequently, a good understanding of dog demography is essential for the control of the disease. The aim of this study was to explore the effect of dog demography on rabies vaccination coverage following a mass vaccination campaign with at least 70% vaccination coverage. METHODOLOGY/PRINCIPAL FINDINGS:A dog population model was constructed to explore the effect of dog demography on rabies vaccination coverage decline. Important model parameters were identified through a comprehensive literature search on dog demography in Africa. A system dynamics approach was adopted to build a dog population model to simulate the effects of demographic processes on rabies vaccination coverage. Vensim PLE Plus software was used to construct the model. Multivariate sensitivity simulations using data from 22 studies and 12 African countries were performed to investigate the effect of dog turnover rates on vaccination coverage decline. In addition, an adjusted vaccination coverage to estimate the proportion of vaccinated dogs with adequate immunity at 12 months post-vaccination was calculated. The results demonstrated that the vaccination coverage and adjusted vaccination coverage remained over 30% and 20% respectively at 12 months if annual mass vaccinations achieved at least 70% coverage. CONCLUSIONS/SIGNIFICANCE:The results demonstrated that annual mass vaccination campaigns with at least 70% vaccination coverage would maintain a herd immunity of 20‒45% between campaigns.http://europepmc.org/articles/PMC6201891?pdf=render |
| spellingShingle | Nozyechi Ngulube Chidumayo System dynamics modelling approach to explore the effect of dog demography on rabies vaccination coverage in Africa. PLoS ONE |
| title | System dynamics modelling approach to explore the effect of dog demography on rabies vaccination coverage in Africa. |
| title_full | System dynamics modelling approach to explore the effect of dog demography on rabies vaccination coverage in Africa. |
| title_fullStr | System dynamics modelling approach to explore the effect of dog demography on rabies vaccination coverage in Africa. |
| title_full_unstemmed | System dynamics modelling approach to explore the effect of dog demography on rabies vaccination coverage in Africa. |
| title_short | System dynamics modelling approach to explore the effect of dog demography on rabies vaccination coverage in Africa. |
| title_sort | system dynamics modelling approach to explore the effect of dog demography on rabies vaccination coverage in africa |
| url | http://europepmc.org/articles/PMC6201891?pdf=render |
| work_keys_str_mv | AT nozyechingulubechidumayo systemdynamicsmodellingapproachtoexploretheeffectofdogdemographyonrabiesvaccinationcoverageinafrica |