Utilization of Biopolymer-Based Lutein Emulsion as an Effective Delivery System to Improve Lutein Bioavailability in Neonatal Rats
Newborns’ eyes and brains are prone to oxidative stress. Lutein has antioxidant properties and is the main component of macular pigment essential for protecting the retina, but has low bioavailability, thereby limiting its potential as a nutritional supplement. Oil-in-water emulsions have been used...
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MDPI AG
2024-01-01
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| Series: | Nutrients |
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| Online Access: | https://www.mdpi.com/2072-6643/16/3/422 |
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| author | Yanqi Zhang Lingyan Kong Jeannine C. Lawrence Libo Tan |
| author_facet | Yanqi Zhang Lingyan Kong Jeannine C. Lawrence Libo Tan |
| author_sort | Yanqi Zhang |
| collection | DOAJ |
| description | Newborns’ eyes and brains are prone to oxidative stress. Lutein has antioxidant properties and is the main component of macular pigment essential for protecting the retina, but has low bioavailability, thereby limiting its potential as a nutritional supplement. Oil-in-water emulsions have been used as lutein delivery systems. In particular, octenylsuccinated (OS) starch is a biopolymer-derived emulsifier safe to use in infant foods, while exhibiting superior emulsifying capacity. This study determined the effects of an OS starch-stabilized lutein emulsion on lutein bioavailability in Sprague-Dawley neonatal rats. In an acute study, 10-day-old pups received a single oral dose of free lutein or lutein emulsion, with subsequent blood sampling over 24 h to analyze pharmacokinetics. The lutein emulsion group had a 2.12- and 1.91-fold higher maximum serum lutein concentration and area under the curve, respectively, compared to the free lutein group. In two daily dosing studies, oral lutein was given from postnatal day 5 to 18. Blood and tissue lutein concentrations were measured. The results indicated that the daily intake of lutein emulsion led to a higher lutein concentration in circulation and key tissues compared to free lutein. The OS starch-stabilized emulsion could be an effective and safe lutein delivery system for newborns. |
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| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-08T03:50:57Z |
| publishDate | 2024-01-01 |
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| series | Nutrients |
| spelling | doaj.art-a27c3389b8974fe5a17dd53a99c9f7452024-02-09T15:19:55ZengMDPI AGNutrients2072-66432024-01-0116342210.3390/nu16030422Utilization of Biopolymer-Based Lutein Emulsion as an Effective Delivery System to Improve Lutein Bioavailability in Neonatal RatsYanqi Zhang0Lingyan Kong1Jeannine C. Lawrence2Libo Tan3Department of Human Nutrition and Hospitality Management, University of Alabama, Tuscaloosa, AL 35487, USADepartment of Human Nutrition and Hospitality Management, University of Alabama, Tuscaloosa, AL 35487, USADepartment of Human Nutrition and Hospitality Management, University of Alabama, Tuscaloosa, AL 35487, USADepartment of Human Nutrition and Hospitality Management, University of Alabama, Tuscaloosa, AL 35487, USANewborns’ eyes and brains are prone to oxidative stress. Lutein has antioxidant properties and is the main component of macular pigment essential for protecting the retina, but has low bioavailability, thereby limiting its potential as a nutritional supplement. Oil-in-water emulsions have been used as lutein delivery systems. In particular, octenylsuccinated (OS) starch is a biopolymer-derived emulsifier safe to use in infant foods, while exhibiting superior emulsifying capacity. This study determined the effects of an OS starch-stabilized lutein emulsion on lutein bioavailability in Sprague-Dawley neonatal rats. In an acute study, 10-day-old pups received a single oral dose of free lutein or lutein emulsion, with subsequent blood sampling over 24 h to analyze pharmacokinetics. The lutein emulsion group had a 2.12- and 1.91-fold higher maximum serum lutein concentration and area under the curve, respectively, compared to the free lutein group. In two daily dosing studies, oral lutein was given from postnatal day 5 to 18. Blood and tissue lutein concentrations were measured. The results indicated that the daily intake of lutein emulsion led to a higher lutein concentration in circulation and key tissues compared to free lutein. The OS starch-stabilized emulsion could be an effective and safe lutein delivery system for newborns.https://www.mdpi.com/2072-6643/16/3/422luteinbiopolymeroil-in-water emulsionbioavailabilityneonatal health |
| spellingShingle | Yanqi Zhang Lingyan Kong Jeannine C. Lawrence Libo Tan Utilization of Biopolymer-Based Lutein Emulsion as an Effective Delivery System to Improve Lutein Bioavailability in Neonatal Rats Nutrients lutein biopolymer oil-in-water emulsion bioavailability neonatal health |
| title | Utilization of Biopolymer-Based Lutein Emulsion as an Effective Delivery System to Improve Lutein Bioavailability in Neonatal Rats |
| title_full | Utilization of Biopolymer-Based Lutein Emulsion as an Effective Delivery System to Improve Lutein Bioavailability in Neonatal Rats |
| title_fullStr | Utilization of Biopolymer-Based Lutein Emulsion as an Effective Delivery System to Improve Lutein Bioavailability in Neonatal Rats |
| title_full_unstemmed | Utilization of Biopolymer-Based Lutein Emulsion as an Effective Delivery System to Improve Lutein Bioavailability in Neonatal Rats |
| title_short | Utilization of Biopolymer-Based Lutein Emulsion as an Effective Delivery System to Improve Lutein Bioavailability in Neonatal Rats |
| title_sort | utilization of biopolymer based lutein emulsion as an effective delivery system to improve lutein bioavailability in neonatal rats |
| topic | lutein biopolymer oil-in-water emulsion bioavailability neonatal health |
| url | https://www.mdpi.com/2072-6643/16/3/422 |
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