Predictive significance of preoperative CT findings for suboptimal cytoreduction in advanced ovarian cancer: a meta-analysis
Ting Wen Yi Hu,1 Dan Nie,1,2 Jin Hai Gou,1,3 Zheng Yu Li1,3 1Department of Gynecology and Obstetrics, West China Second University Hospital, Sichuan University, Chengdu, People’s Republic of China; 2Key Laboratory of Obstetrics and Gynecologic and Pediatric Diseases and Birth Defects of Mi...
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2018-07-01
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| Series: | Cancer Management and Research |
| Subjects: | |
| Online Access: | https://www.dovepress.com/predictive-significance-of-preoperative-ct-findings-for-suboptimal-cyt-peer-reviewed-article-CMAR |
| _version_ | 1819087406476820480 |
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| author | Hu TWY Nie D Gou JH Li ZY |
| author_facet | Hu TWY Nie D Gou JH Li ZY |
| author_sort | Hu TWY |
| collection | DOAJ |
| description | Ting Wen Yi Hu,1 Dan Nie,1,2 Jin Hai Gou,1,3 Zheng Yu Li1,3 1Department of Gynecology and Obstetrics, West China Second University Hospital, Sichuan University, Chengdu, People’s Republic of China; 2Key Laboratory of Obstetrics and Gynecologic and Pediatric Diseases and Birth Defects of Ministry of Education, West China Second Hospital, Sichuan University, Chengdu, People’s Republic of China; 3The State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, People’s Republic of China Background: Computed tomography (CT) has been extensively used in predicting suboptimal cytoreduction (SCR) in advanced ovarian cancer (OC). However, disagreements remain in literatures on the predictive value of CT findings for SCR. This meta-analysis was designed to determine the ability of eight preoperative CT findings to predict SCR in advanced OC. Materials and methods: A comprehensive literature search was conducted for eligible studies to identify the association between the eight preoperative CT findings and SCR in advanced OC. The predictive performances of preoperative CT findings were expressed in terms of sensitivity, specificity, positive likelihood ratio (PLR), negative likelihood ratio (NLR) and diagnostic odds ratio (DOR) with pooled proportion. Results: A total of 10 studies and 1,614 patients were included in this meta-analysis. Large volume ascites had the highest sensitivity (64%, CI 56–71%), with a PLR of 1.3 (CI 1.1–1.5) and an NLR of 0.73 (0.59–0.90), while lymph node involvement had the highest specificity (89%, CI 79–94%). The highest DOR of 3 (CI 2–4) was achieved in peritoneal involvement and large bowel mesentery involvement. The other CT findings had poorer predictive performance. Conclusion: Preoperative CT findings have a poor discriminative capacity to predict SCR in advanced OC. Preoperative CT predictors should be used with caution amid clinical decision-making. Keywords: computed tomography, suboptimal cytoreduction, ovarian cancer, meta-analysis, predict |
| first_indexed | 2024-12-21T21:35:38Z |
| format | Article |
| id | doaj.art-a27e514b2fbd4625bb96cca44dfd0963 |
| institution | Directory Open Access Journal |
| issn | 1179-1322 |
| language | English |
| last_indexed | 2024-12-21T21:35:38Z |
| publishDate | 2018-07-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Cancer Management and Research |
| spelling | doaj.art-a27e514b2fbd4625bb96cca44dfd09632022-12-21T18:49:30ZengDove Medical PressCancer Management and Research1179-13222018-07-01Volume 102019203039332Predictive significance of preoperative CT findings for suboptimal cytoreduction in advanced ovarian cancer: a meta-analysisHu TWYNie DGou JHLi ZYTing Wen Yi Hu,1 Dan Nie,1,2 Jin Hai Gou,1,3 Zheng Yu Li1,3 1Department of Gynecology and Obstetrics, West China Second University Hospital, Sichuan University, Chengdu, People’s Republic of China; 2Key Laboratory of Obstetrics and Gynecologic and Pediatric Diseases and Birth Defects of Ministry of Education, West China Second Hospital, Sichuan University, Chengdu, People’s Republic of China; 3The State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, People’s Republic of China Background: Computed tomography (CT) has been extensively used in predicting suboptimal cytoreduction (SCR) in advanced ovarian cancer (OC). However, disagreements remain in literatures on the predictive value of CT findings for SCR. This meta-analysis was designed to determine the ability of eight preoperative CT findings to predict SCR in advanced OC. Materials and methods: A comprehensive literature search was conducted for eligible studies to identify the association between the eight preoperative CT findings and SCR in advanced OC. The predictive performances of preoperative CT findings were expressed in terms of sensitivity, specificity, positive likelihood ratio (PLR), negative likelihood ratio (NLR) and diagnostic odds ratio (DOR) with pooled proportion. Results: A total of 10 studies and 1,614 patients were included in this meta-analysis. Large volume ascites had the highest sensitivity (64%, CI 56–71%), with a PLR of 1.3 (CI 1.1–1.5) and an NLR of 0.73 (0.59–0.90), while lymph node involvement had the highest specificity (89%, CI 79–94%). The highest DOR of 3 (CI 2–4) was achieved in peritoneal involvement and large bowel mesentery involvement. The other CT findings had poorer predictive performance. Conclusion: Preoperative CT findings have a poor discriminative capacity to predict SCR in advanced OC. Preoperative CT predictors should be used with caution amid clinical decision-making. Keywords: computed tomography, suboptimal cytoreduction, ovarian cancer, meta-analysis, predicthttps://www.dovepress.com/predictive-significance-of-preoperative-ct-findings-for-suboptimal-cyt-peer-reviewed-article-CMARcomputed tomographysuboptimal cytoreductionovarian cancermeta-analysispredict. |
| spellingShingle | Hu TWY Nie D Gou JH Li ZY Predictive significance of preoperative CT findings for suboptimal cytoreduction in advanced ovarian cancer: a meta-analysis Cancer Management and Research computed tomography suboptimal cytoreduction ovarian cancer meta-analysis predict. |
| title | Predictive significance of preoperative CT findings for suboptimal cytoreduction in advanced ovarian cancer: a meta-analysis |
| title_full | Predictive significance of preoperative CT findings for suboptimal cytoreduction in advanced ovarian cancer: a meta-analysis |
| title_fullStr | Predictive significance of preoperative CT findings for suboptimal cytoreduction in advanced ovarian cancer: a meta-analysis |
| title_full_unstemmed | Predictive significance of preoperative CT findings for suboptimal cytoreduction in advanced ovarian cancer: a meta-analysis |
| title_short | Predictive significance of preoperative CT findings for suboptimal cytoreduction in advanced ovarian cancer: a meta-analysis |
| title_sort | predictive significance of preoperative ct findings for suboptimal cytoreduction in advanced ovarian cancer a meta analysis |
| topic | computed tomography suboptimal cytoreduction ovarian cancer meta-analysis predict. |
| url | https://www.dovepress.com/predictive-significance-of-preoperative-ct-findings-for-suboptimal-cyt-peer-reviewed-article-CMAR |
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