The associations between suicide-related behaviors, prefrontal dysfunction in emotional cognition, and personality traits in mood disorders
Abstract Suicide is a serious public health problem, and it is urgent to identify biomarkers associated with suicide to prevent it. We aimed to clarify the association across suicidal behavior, personality traits, and brain activation by emotional stimulation tasks using near-infrared spectroscopy (...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2022-10-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-022-22345-3 |
| _version_ | 1798028627552501760 |
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| author | Hisashi Kamimura Takahiro Matsuoka Hiroshi Okai Naoki Shimizu Shu Harada Koji Matsuo |
| author_facet | Hisashi Kamimura Takahiro Matsuoka Hiroshi Okai Naoki Shimizu Shu Harada Koji Matsuo |
| author_sort | Hisashi Kamimura |
| collection | DOAJ |
| description | Abstract Suicide is a serious public health problem, and it is urgent to identify biomarkers associated with suicide to prevent it. We aimed to clarify the association across suicidal behavior, personality traits, and brain activation by emotional stimulation tasks using near-infrared spectroscopy (NIRS) in patients with mood disorders. 11 mood disorder patients with a history of suicide attempt (MDSA), 18 mood disorder patients with no history of suicide attempt (MDNSA), and 17 healthy individuals were studied. The MDSA patients showed significantly high impulsivity and hopeless compared to healthy subjects, great response to the thread word task in the orbitofrontal cortex (OFC) and dorsolateral prefrontal cortex (DLPFC) compared to MDNSA patients, and the significant correlation between the personality traits and brain activation. The MDNSA did not show the trend. The results suggest that the personality traits and the activation of OFC and DLPFC during the negative emotional cognitive stimuli is associated with suicidal behavior, indicating the findings are involved in the pathophysiology of suicidality in mood disorders. |
| first_indexed | 2024-04-11T19:10:59Z |
| format | Article |
| id | doaj.art-a27f2d0cb1f14308b5449c2f13b446da |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-04-11T19:10:59Z |
| publishDate | 2022-10-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-a27f2d0cb1f14308b5449c2f13b446da2022-12-22T04:07:37ZengNature PortfolioScientific Reports2045-23222022-10-0112111210.1038/s41598-022-22345-3The associations between suicide-related behaviors, prefrontal dysfunction in emotional cognition, and personality traits in mood disordersHisashi Kamimura0Takahiro Matsuoka1Hiroshi Okai2Naoki Shimizu3Shu Harada4Koji Matsuo5Department of Psychiatry, Faculty of Medicine, Saitama Medical UniversityDepartment of Psychiatry, Faculty of Medicine, Saitama Medical UniversityDepartment of Psychiatry, Faculty of Medicine, Saitama Medical UniversityDepartment of Psychiatry, Faculty of Medicine, Saitama Medical UniversityDepartment of Psychiatry, Faculty of Medicine, Saitama Medical UniversityDepartment of Psychiatry, Faculty of Medicine, Saitama Medical UniversityAbstract Suicide is a serious public health problem, and it is urgent to identify biomarkers associated with suicide to prevent it. We aimed to clarify the association across suicidal behavior, personality traits, and brain activation by emotional stimulation tasks using near-infrared spectroscopy (NIRS) in patients with mood disorders. 11 mood disorder patients with a history of suicide attempt (MDSA), 18 mood disorder patients with no history of suicide attempt (MDNSA), and 17 healthy individuals were studied. The MDSA patients showed significantly high impulsivity and hopeless compared to healthy subjects, great response to the thread word task in the orbitofrontal cortex (OFC) and dorsolateral prefrontal cortex (DLPFC) compared to MDNSA patients, and the significant correlation between the personality traits and brain activation. The MDNSA did not show the trend. The results suggest that the personality traits and the activation of OFC and DLPFC during the negative emotional cognitive stimuli is associated with suicidal behavior, indicating the findings are involved in the pathophysiology of suicidality in mood disorders.https://doi.org/10.1038/s41598-022-22345-3 |
| spellingShingle | Hisashi Kamimura Takahiro Matsuoka Hiroshi Okai Naoki Shimizu Shu Harada Koji Matsuo The associations between suicide-related behaviors, prefrontal dysfunction in emotional cognition, and personality traits in mood disorders Scientific Reports |
| title | The associations between suicide-related behaviors, prefrontal dysfunction in emotional cognition, and personality traits in mood disorders |
| title_full | The associations between suicide-related behaviors, prefrontal dysfunction in emotional cognition, and personality traits in mood disorders |
| title_fullStr | The associations between suicide-related behaviors, prefrontal dysfunction in emotional cognition, and personality traits in mood disorders |
| title_full_unstemmed | The associations between suicide-related behaviors, prefrontal dysfunction in emotional cognition, and personality traits in mood disorders |
| title_short | The associations between suicide-related behaviors, prefrontal dysfunction in emotional cognition, and personality traits in mood disorders |
| title_sort | associations between suicide related behaviors prefrontal dysfunction in emotional cognition and personality traits in mood disorders |
| url | https://doi.org/10.1038/s41598-022-22345-3 |
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