Comparative Biochemical Outcomes, Effectiveness and Tolerance of Densiron 68 and Oxane HD for the Management of Complicated Retinal Detachment
Objectives:To compare biochemical outcomes, effectiveness, and tolerance of two high-density silicone oils (HDSOs), silicone oil- RMN3 (Oxane® HD) and silicone oil-Densiron-68 (Densiron® 68), for the management of complicated retinal detachment (RD) associated with inferior proliferative vitreoretin...
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| Format: | Article |
| Language: | English |
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Galenos Yayinevi
2019-12-01
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| Series: | Türk Oftalmoloji Dergisi |
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| Online Access: |
http://www.oftalmoloji.org/archives/archive-detail/article-preview/comparative-biochemical-outcomes-effectiveness-and/34585
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| _version_ | 1797915388096282624 |
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| author | Chafik Keilani Edouard Augstburger Mathieu Robin Amélie Beaugrand Raphaëlle Ores José-Alain Sahel Sarah Ayello-Scheer |
| author_facet | Chafik Keilani Edouard Augstburger Mathieu Robin Amélie Beaugrand Raphaëlle Ores José-Alain Sahel Sarah Ayello-Scheer |
| author_sort | Chafik Keilani |
| collection | DOAJ |
| description | Objectives:To compare biochemical outcomes, effectiveness, and tolerance of two high-density silicone oils (HDSOs), silicone oil- RMN3 (Oxane® HD) and silicone oil-Densiron-68 (Densiron® 68), for the management of complicated retinal detachment (RD) associated with inferior proliferative vitreoretinopathy (PVR).Materials and Methods:This was a retrospective, single-centre, comparative case series of 23 patients treated between September 2014 and June 2016. The main inclusion criteria were RD with inferior PVR receiving Oxane® HD or Densiron® 68 following pars plana vitrectomy. The main outcome measures were anatomical success, rate of RD recurrence, and best-corrected visual acuity (BCVA) at 6 months. Secondary outcomes were short-term complications.Results:Twenty-three eyes were included: 16 eyes with Densiron® 68 tamponade and 7 eyes with Oxane® HD tamponade. Anatomical success under HDSO was significantly higher in the Densiron® 68 group (100%) than in the Oxane® HD group (42.8%) (p=0.0455). Recurrent RD was observed in 42.8% of eyes under Oxane® HD, but in none of the patients under Densiron® 68 (p=0.001). Six months after surgery, mean BVCA values (+/- standard deviation) with Densiron® 68 and Oxane® HD were 0.83±0.62 logMAR and 1.81±0.65 logMAR, respectively. BVCA was significantly better in the Densiron® 68 group (p=0.006). No significant differences were observed with regard to intraocular pressure, emulsification, or intraocular inflammation.Conclusion:Densiron® 68 appears to be more effective than Oxane® HD for the management of RD associated with PVR. A randomized, controlled, interventional study is needed to demonstrate this difference. |
| first_indexed | 2024-04-10T12:40:48Z |
| format | Article |
| id | doaj.art-a27f40a0b10d4793931a0ad9f0faa46b |
| institution | Directory Open Access Journal |
| issn | 1300-0659 2147-2661 |
| language | English |
| last_indexed | 2024-04-10T12:40:48Z |
| publishDate | 2019-12-01 |
| publisher | Galenos Yayinevi |
| record_format | Article |
| series | Türk Oftalmoloji Dergisi |
| spelling | doaj.art-a27f40a0b10d4793931a0ad9f0faa46b2023-02-15T16:14:17ZengGalenos YayineviTürk Oftalmoloji Dergisi1300-06592147-26612019-12-0149633434110.4274/tjo.galenos.2019.2429413049054Comparative Biochemical Outcomes, Effectiveness and Tolerance of Densiron 68 and Oxane HD for the Management of Complicated Retinal DetachmentChafik Keilani0Edouard Augstburger1Mathieu Robin2Amélie Beaugrand3Raphaëlle Ores4José-Alain Sahel5Sarah Ayello-Scheer6 Sorbonne Üniversitesi Pierre-et-Marie-Curie Tıp Fakültesi, Quinze-Vingts Ulusal Hastanesi, Oftalmoloji IV Anabilim Dalı, Paris, Fransa Quinze-Vingts Ulusal Hastanesi, Oftalmoloji Anabilim Dalı, Paris, Fransa Quinze-Vingts Ulusal Hastanesi, Oftalmoloji Anabilim Dalı, Paris, Fransa Quinze-Vingts Ulusal Hastanesi, Oftalmoloji III Anabilim Dalı, Paris, Fransa Quinze-Vingts Ulusal Hastanesi, Biyomedikal Enformatik Anabilim Dalı, Paris, Fransa Quinze-Vingts Ulusal Hastanesi, Biyomedikal Enformatik Anabilim Dalı, Paris, Fransa Quinze-Vingts Ulusal Hastanesi, Biyomedikal Enformatik Anabilim Dalı, Paris, Fransa Objectives:To compare biochemical outcomes, effectiveness, and tolerance of two high-density silicone oils (HDSOs), silicone oil- RMN3 (Oxane® HD) and silicone oil-Densiron-68 (Densiron® 68), for the management of complicated retinal detachment (RD) associated with inferior proliferative vitreoretinopathy (PVR).Materials and Methods:This was a retrospective, single-centre, comparative case series of 23 patients treated between September 2014 and June 2016. The main inclusion criteria were RD with inferior PVR receiving Oxane® HD or Densiron® 68 following pars plana vitrectomy. The main outcome measures were anatomical success, rate of RD recurrence, and best-corrected visual acuity (BCVA) at 6 months. Secondary outcomes were short-term complications.Results:Twenty-three eyes were included: 16 eyes with Densiron® 68 tamponade and 7 eyes with Oxane® HD tamponade. Anatomical success under HDSO was significantly higher in the Densiron® 68 group (100%) than in the Oxane® HD group (42.8%) (p=0.0455). Recurrent RD was observed in 42.8% of eyes under Oxane® HD, but in none of the patients under Densiron® 68 (p=0.001). Six months after surgery, mean BVCA values (+/- standard deviation) with Densiron® 68 and Oxane® HD were 0.83±0.62 logMAR and 1.81±0.65 logMAR, respectively. BVCA was significantly better in the Densiron® 68 group (p=0.006). No significant differences were observed with regard to intraocular pressure, emulsification, or intraocular inflammation.Conclusion:Densiron® 68 appears to be more effective than Oxane® HD for the management of RD associated with PVR. A randomized, controlled, interventional study is needed to demonstrate this difference. http://www.oftalmoloji.org/archives/archive-detail/article-preview/comparative-biochemical-outcomes-effectiveness-and/34585 high-density silicone oilsdensiron® 68oxane® hdcomplicated inferior retinal detachmentproliferative vitreoretinopathy |
| spellingShingle | Chafik Keilani Edouard Augstburger Mathieu Robin Amélie Beaugrand Raphaëlle Ores José-Alain Sahel Sarah Ayello-Scheer Comparative Biochemical Outcomes, Effectiveness and Tolerance of Densiron 68 and Oxane HD for the Management of Complicated Retinal Detachment Türk Oftalmoloji Dergisi high-density silicone oils densiron® 68 oxane® hd complicated inferior retinal detachment proliferative vitreoretinopathy |
| title | Comparative Biochemical Outcomes, Effectiveness and Tolerance of Densiron 68 and Oxane HD for the Management of Complicated Retinal Detachment |
| title_full | Comparative Biochemical Outcomes, Effectiveness and Tolerance of Densiron 68 and Oxane HD for the Management of Complicated Retinal Detachment |
| title_fullStr | Comparative Biochemical Outcomes, Effectiveness and Tolerance of Densiron 68 and Oxane HD for the Management of Complicated Retinal Detachment |
| title_full_unstemmed | Comparative Biochemical Outcomes, Effectiveness and Tolerance of Densiron 68 and Oxane HD for the Management of Complicated Retinal Detachment |
| title_short | Comparative Biochemical Outcomes, Effectiveness and Tolerance of Densiron 68 and Oxane HD for the Management of Complicated Retinal Detachment |
| title_sort | comparative biochemical outcomes effectiveness and tolerance of densiron 68 and oxane hd for the management of complicated retinal detachment |
| topic | high-density silicone oils densiron® 68 oxane® hd complicated inferior retinal detachment proliferative vitreoretinopathy |
| url |
http://www.oftalmoloji.org/archives/archive-detail/article-preview/comparative-biochemical-outcomes-effectiveness-and/34585
|
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