KNa1.1 gain-of-function preferentially dampens excitability of murine parvalbumin-positive interneurons

KNa1.1 gain-of-function preferentially dampens excitability of murine parvalbumin-positive interneurons

KCNT1 encodes the sodium-activated potassium channel KNa1.1, expressed preferentially in the frontal cortex, hippocampus, cerebellum, and brainstem. Pathogenic missense variants in KCNT1 are associated with intractable epilepsy, namely epilepsy of infancy with migrating focal seizures (EIMFS), and s...

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Bibliographic Details
Main Authors: Tracy S. Gertler, Suraj Cherian, Jean-Marc DeKeyser, Jennifer A. Kearney, Alfred L. George, Jr
Format: Article
Language:English
Published: Elsevier 2022-06-01
Series:Neurobiology of Disease
Subjects:
Epilepsy
Potassium channel
KCNT1
Interneuron
Mouse
Online Access:http://www.sciencedirect.com/science/article/pii/S096999612200105X

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