Cerium Oxide Nanoparticles Absorption through Intact and Damaged Human Skin
Cerium oxide (CeO<sub>2</sub>) nanoparticles (NPs) are used in polishing products and absorbents, as promoters in wound healing, and as organopesticide decontaminants. While systemic bioaccumulation and organ toxicity has been described after inhalation, data on CeO<sub>2</sub&g...
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| Format: | Article |
| Language: | English |
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MDPI AG
2019-10-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/24/20/3759 |
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| author | Marcella Mauro Matteo Crosera Matteo Monai Tiziano Montini Paolo Fornasiero Massimo Bovenzi Gianpiero Adami Gianluca Turco Francesca Larese Filon |
| author_facet | Marcella Mauro Matteo Crosera Matteo Monai Tiziano Montini Paolo Fornasiero Massimo Bovenzi Gianpiero Adami Gianluca Turco Francesca Larese Filon |
| author_sort | Marcella Mauro |
| collection | DOAJ |
| description | Cerium oxide (CeO<sub>2</sub>) nanoparticles (NPs) are used in polishing products and absorbents, as promoters in wound healing, and as organopesticide decontaminants. While systemic bioaccumulation and organ toxicity has been described after inhalation, data on CeO<sub>2</sub> NPs’ transdermal permeation are lacking. Our study was an in vitro investigation of the permeation of 17-nm CeO<sub>2</sub> NPs dispersed in synthetic sweat (1 g L<sup>−1</sup>) using excised human skin on Franz cells. Experiments were performed using intact and needle-abraded skin, separately. The average amount of Ce into intact and damaged skin samples was 3.64 ± 0.15 and 7.07 ± 0.78 µg cm<sup>−2</sup>, respectively (mean ± SD, <i>p</i> = 0.04). Ce concentration in the receiving solution was 2.0 ± 0.4 and 3.3 ± 0.7 ng cm<sup>−2</sup> after 24 h (<i>p</i> = 0.008). The Ce content was higher in dermal layers of damaged skin compared to intact skin (2.93 ± 0.71 µg cm<sup>−2</sup> and 0.39 ± 0.16 µg cm<sup>−2</sup>, respectively; <i>p</i> = 0.004). Our data showed a very low dermal absorption and transdermal permeation of cerium, providing a first indication of Ce skin uptake due to contact with CeO<sub>2</sub>. |
| first_indexed | 2024-12-11T09:05:39Z |
| format | Article |
| id | doaj.art-a282a0cfbfbd4aa8bdabb2b5f97b1702 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-12-11T09:05:39Z |
| publishDate | 2019-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-a282a0cfbfbd4aa8bdabb2b5f97b17022022-12-22T01:13:38ZengMDPI AGMolecules1420-30492019-10-012420375910.3390/molecules24203759molecules24203759Cerium Oxide Nanoparticles Absorption through Intact and Damaged Human SkinMarcella Mauro0Matteo Crosera1Matteo Monai2Tiziano Montini3Paolo Fornasiero4Massimo Bovenzi5Gianpiero Adami6Gianluca Turco7Francesca Larese Filon8Clinical Unit of Occupational Medicine, Department of Medical Sciences, University of Trieste, Via della Pietà 19, 34100 Trieste, ItalyDepartment of Chemical and Pharmaceutical Sciences, University of Trieste, Via Giorgieri 1, 34127 Trieste, ItalyDepartment of Chemical and Pharmaceutical Sciences, University of Trieste, Via Giorgieri 1, 34127 Trieste, ItalyDepartment of Chemical and Pharmaceutical Sciences, University of Trieste, Via Giorgieri 1, 34127 Trieste, ItalyDepartment of Chemical and Pharmaceutical Sciences, University of Trieste, Via Giorgieri 1, 34127 Trieste, ItalyClinical Unit of Occupational Medicine, Department of Medical Sciences, University of Trieste, Via della Pietà 19, 34100 Trieste, ItalyDepartment of Chemical and Pharmaceutical Sciences, University of Trieste, Via Giorgieri 1, 34127 Trieste, ItalyDepartment of Medical Sciences, University of Trieste, Piazza dell’Ospitale 1, 34125 Trieste, ItalyClinical Unit of Occupational Medicine, Department of Medical Sciences, University of Trieste, Via della Pietà 19, 34100 Trieste, ItalyCerium oxide (CeO<sub>2</sub>) nanoparticles (NPs) are used in polishing products and absorbents, as promoters in wound healing, and as organopesticide decontaminants. While systemic bioaccumulation and organ toxicity has been described after inhalation, data on CeO<sub>2</sub> NPs’ transdermal permeation are lacking. Our study was an in vitro investigation of the permeation of 17-nm CeO<sub>2</sub> NPs dispersed in synthetic sweat (1 g L<sup>−1</sup>) using excised human skin on Franz cells. Experiments were performed using intact and needle-abraded skin, separately. The average amount of Ce into intact and damaged skin samples was 3.64 ± 0.15 and 7.07 ± 0.78 µg cm<sup>−2</sup>, respectively (mean ± SD, <i>p</i> = 0.04). Ce concentration in the receiving solution was 2.0 ± 0.4 and 3.3 ± 0.7 ng cm<sup>−2</sup> after 24 h (<i>p</i> = 0.008). The Ce content was higher in dermal layers of damaged skin compared to intact skin (2.93 ± 0.71 µg cm<sup>−2</sup> and 0.39 ± 0.16 µg cm<sup>−2</sup>, respectively; <i>p</i> = 0.004). Our data showed a very low dermal absorption and transdermal permeation of cerium, providing a first indication of Ce skin uptake due to contact with CeO<sub>2</sub>.https://www.mdpi.com/1420-3049/24/20/3759franz cellsin vitrocerium oxide nanoparticlestransdermal absorption |
| spellingShingle | Marcella Mauro Matteo Crosera Matteo Monai Tiziano Montini Paolo Fornasiero Massimo Bovenzi Gianpiero Adami Gianluca Turco Francesca Larese Filon Cerium Oxide Nanoparticles Absorption through Intact and Damaged Human Skin Molecules franz cells in vitro cerium oxide nanoparticles transdermal absorption |
| title | Cerium Oxide Nanoparticles Absorption through Intact and Damaged Human Skin |
| title_full | Cerium Oxide Nanoparticles Absorption through Intact and Damaged Human Skin |
| title_fullStr | Cerium Oxide Nanoparticles Absorption through Intact and Damaged Human Skin |
| title_full_unstemmed | Cerium Oxide Nanoparticles Absorption through Intact and Damaged Human Skin |
| title_short | Cerium Oxide Nanoparticles Absorption through Intact and Damaged Human Skin |
| title_sort | cerium oxide nanoparticles absorption through intact and damaged human skin |
| topic | franz cells in vitro cerium oxide nanoparticles transdermal absorption |
| url | https://www.mdpi.com/1420-3049/24/20/3759 |
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